130 years of cyclodextrin discovery for health, food, agriculture, and the industry: a review

Abstract

Cyclodextrins are a group of cyclic oligosaccharides obtained by enzymatic degradation of starch. They are remarkable macrocyclic molecules that have led major theoretical and practical advances in chemistry, biology, biochemistry, health science, and agriculture. Their molecular structure is composed of a hydrophobic cavity that can encapsulate other compounds to form inclusion complexes through host-guest interactions. This unique feature is at the origin of many applications. Cyclodextrins and their derivatives have a wide variety of practical applications in almost all sectors of the industry, including pharmacy, medicine, foods, cosmetics, chromatography, catalysis, biotechnology, and the textile industry. Villiers published the first reference to cyclodextrins in 1891, and since then, these molecules have continued to fascinate academia and industry. Currently, more than 2000 publications on cyclodextrins are published each year. On the occasion of the 130th anniversary of their discovery, in this review, we present an historical overview of the development and applications of cyclodextrins. First, we present the discovery and first chemical studies on cyclodextrins. Then, the main results obtained during the 1911-1970 exploration period are discussed. A third part presents the historical landmarks in the development of cyclodextrins from 1970 to the present day.

Distinctive Supramolecular Features of β-Cyclodextrin Inclusion Complexes with Antidepressants Protriptyline and Maprotiline: A Comprehensive Structural Investigation

“…Cyclodextrins (CDs) are the most versatile encapsulating agents because they have a broad application spectrum, including pharmaceutics, cosmetics, medicine, food, agriculture, chromatography, biotechnology, and nanotechnology [ 11 , 12 , 13 , 14 ]. The excellent inclusion ability of CDs is attributed to their amphipathic character and nanocavity size, stabilizing and interacting intermolecularly with various guest molecules [ 15 , 16 ].…”

The Contribution of NMR Spectroscopy in Understanding Perovskite Stabilization Phenomena

“…We recently tested native cyclodextrins (CDs) as solubility promoters for the two precursors [ 21 ]; the increase in the solubility of the inorganic moiety (PbI 2 ) was detected via UV-Vis absorption, whereas NMR was chosen for studying the interactions involving MAI and the macrocycles with different size cavities (α, β and γ in ascending order). Cyclodextrins were chosen because of their well-known ability to establish host-guest interactions with organic molecules: the guest, according to its functional groups, interacts with the hydrophobic inner cavity of the CD and/or with its hydrophilic external surface, decorated by –OH groups [ 52 , 53 , 54 , 55 ].…”

Cyclodextrin Multicomponent Complexes: Pharmaceutical Applications

“…CDs have been used in pharmaceutical formulations since the 1970s. The first pharmaceutical product containing CD, marketed in Japan in 1976, was Prostarmon E™ (prostaglandin E2:βCD) [ 4 ]. Currently, there are various commercial formulations containing CDs.…”