Cyclodextrin as Functional Carrier in Development of Mucoadhesive Tablets Containing Polygoni cuspidati Extract with Potential for Dental Applications

Abstract

Polygoni cuspidati root is a resveratrol-rich source with anti-inflammatory, angiogenic and neuroprotective effects. The raw material was standardized for the content of resveratrol, for which there is a special justification for administration within the oral mucosa. To improve the solubility of resveratrol and to assure its high content in plant material, an ultrasound-assisted extraction method was applied. The addition of cyclodextrin was found to increase the extraction efficiency of resveratrol (from 13 to 297 µg per 1 g of plant material in case of 50% ethanol extracts) and enhanced its antioxidant activity as compared to pure Polygoni cuspidati extract/resveratrol. Cyclodextrin plays the role of a functional extract regarding technological properties (increasing the extraction of resveratrol from the extract, improving mucoadhesive properties). Therefore, the aim of this study was to develop mucoadhesive tablets containing combinations of the Polygoni cuspidati extract with a cyclodextrin carrier for buccal delivery. The tests sequentially included extract preparation and characterization of its physical and biological properties and then formulation studies with a broad description of the prototype properties. The test results indicate that cyclodextrin increases the efficiency of resveratrol extraction from Polygoni cuspidati rhizome, which is a rich source of resveratrol, and its extract enclosed in a mucoadhesive tablet guarantees prolonged action at the site of administration.

Is It Possible to Improve the Bioavailability of Resveratrol and Polydatin Derived from Polygoni cuspidati Radix as a Result of Preparing Electrospun Nanofibers Based on Polyvinylpyrrolidone/Cyclodextrin?

“…The antioxidant properties of P. cuspidati extract have been widely described in literature data [ 8 ]. In the study mentioned above, we indicated that the extract was characterized by the best activity, where 1% m/w of β-cyclodextrin was added to the extraction mixture (ethanol: water (5:5 v:v )).…”

“…The contents of main active compounds (polydatin, resveratrol, emodin and parietin) were determined by using the modified HPLC-Diode-Array Detection method described previously by Paczkowska-Walendowska et al [ 8 ].…”

“…A viscometric method was used to quantify mucin–polymer bioadhesive bond strength. Assessment was performed according to the method described previously [ 8 ].…”

“…Despite the broad spectrum of health-promoting properties, the active compounds (in particular polydatin and resveratrol) are characterized by low water solubility [ 8 ]. Additionally, when administered orally, resveratrol is readily absorbed from the small intestine.…”

Can Plant Materials Be Valuable in the Treatment of Periodontal Diseases? Practical Review

“…Numerous literature data on delivering polyphenols, especially resveratrol by this route is available. It has been proven that by the use of mucoadhesive polymers, a controlled and sustained release of resveratrol at the affected site can be achieved [169,170], which in combination with antioxidant and antibacterial properties can be a potential alternative in the treatment of periodontal diseases.…”