Cycloartane Triterpenoids fromCassia occidentalis

Abstract

A phytochemical investigation of the whole plants of Cassia occidentalis led to the isolation of two new cycloartane triterpenoids, cycloccidentalic acids A and B (1 and 2), and five new related saponins, cycloccidentalisides I-V (3-7), together with sixteen known compounds. The structures of the isolated compounds were elucidated through detailed spectroscopic analyses, including 1D and 2D NMR techniques, and chemical methods. Compounds 2 and 5 showed modest anti-HIV-1 activities with EC₅₀ values of 2.23 µM and 4.36 µM, respectively, in comparison to the positive control.

Anti-inflammatory coumarins from Paramignya trimera

“…Previous studies on the pharmacological effects of the isolated compounds have shown that ostruthin ( 1 ) is cytotoxic toward two human pancreatic cancer cell lines, including PANC-1 and PSN-1 cells in nutrient-deprived medium (Li et al. 2012 ), this compound was shown to inhibit vascular smooth muscle cell proliferation (Joa et al. 2011 ), inhibit acetylcholinesterase activity (Urbain et al.…”

Extracts of Moringa oleifera Lam. showing inhibitory activity against early steps in the infectivity of HIV-1 lentiviral particles in a viral vector-based screening

“…Plant-derived flavonoids have been reported to inhibit critical steps in the life cycle of HIV infectivity such as viral entry (Liu et al, 2011), reverse transcriptase (Li et al, 2011), integrase (Lee et al, 2003;Tewtrakul et al, 2003), viral transcriptional activities of HIV tat (Mehla et al, 2011) and protease inhibitory activities (Lee et al, 2009) and other activities. M. oleifera is also rich in saponins which have been reported to inhibit HIV infectivity, in vitro (Konoshima et al, 1995;Yang et al, 1999;Li et al, 2012).…”

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“…[126] 4-hydroxy benzoic acid hydrate obtained from the extracts of the flower of C. fistula showed antifungal activity against Trichophyton mentagrophytes (MIC 0.5 mg/ml) and Epidermophyton floccosum (MIC 0.5 mg/ml). [126] Anti-HIV Activity Different Cassia species possess various antiviral compounds such as chromones from the stem of Cassia siamea, [127] cycloartane triterpenoids from Cassia occidentalis, [128] Cassia sieberiana D.C., and Cassia abbreviata Oliv. inhibit in vitro HIV-1c replication in peripheral blood mononuclear cells (PBMCs), [129,130] flavones from Cassia siamea, and their anti-tobacco mosaic virus activity [ Table 1].…”