Cycloartane saponins from Astragalus peregrinus as modulators of lymphocyte proliferation

Astragalus membranaceus flavonoids (AMF) ameliorate chronic fatigue syndrome induced by food intake restriction plus forced swimming

“…The root of Astragalus species is known to be rich in polysaccharides, saponins, and flavonoids. The former two compounds of several Astragalus species are reported to possess anticancer and immunity-stimulating effects (Verotta et al, 2001;Lee and Jeon, 2005;Yesilada et al, 2005;Sun et al, 2006). Nevertheless, the latter group of components, flavonoids, is also known as biologically active compounds (Widyarini et al, 2001;Lee et al, 2002).…”

A review of acacic acid-type saponins from Leguminosae-Mimosoideae as potent cytotoxic and apoptosis inducing agents

“…Plants from the Mimosoideae are known for their medicinal value (Allen and Allen 1981) and several saponins have been isolated from this family that inhibit the growth of tumor cells in vitro (Bedir et al 2000;Abdel-Kader et al 2000;Verotta et al 2001;Mujoo et al 2001;Jeong and Kim 2002;Seo et al 2002;Mimaki et al 2003Mimaki et al , 2004Jayatilake et al 2003;Haddad et al 2003). Particularly interesting are acacic acid typesaponins (AATS) having a common aglycone, acacic acid substituted by various oligosaccharide units at C-3-and C-28 and by acyl groups at C-21.…”

Chemical constituents from Astragalus annularis Forssk. and A. trimestris L., Fabaceae

“…Some Astragalus species are also used as diuretics and for treatment of stomach ulcers, diabetes, nephritis, chronic bronchitis, postpartum urine retention and leprosy (Foster, 1998). In the course of our phytochemical investigation of the secondary metabolites from Astragalus species endemic to Egypt, a number of cycloartane saponins, oleanane saponins, flavonoids, isoflavans and spinocoumarins were isolated (El-Sebakhy et al, 2000;Gabriboldi et al, 1995;Orsini et al, 1994;Radwan et al, 2007;Verotta et al, 2001). …”