Cyclin D1 gene polymorphism as a risk factor for squamous cell carcinoma of the upper aerodigestive system in non-alcoholics

HPV infection and the alterations of the pRB pathway in oral carcinogenesis

“…Cyclin D1 and CDK4 are downstream proteins/effectors of p16 INK4A which catalyze the phosphorylation of pRB, leading to the dissociation of pRB from E2F (22). Cyclin D1 is often overexpressed at both transcriptional and translational levels, and associated with a more rapid and frequent recurrence of cancer (23).…”

Cyclin D1 polymorphism (G870A) and risk for esophageal adenocarcinoma

“…15 It was proposed initially that DNA-damaged cells in individuals with the A allele may bypass the G 1 /S checkpoint, resulting in the accumulation of an increased proportion of cells with DNA damage and genetic alterations. 26 Subsequent studies have demonstrated an association between the CCND1 A/A genotype and increased risk for various human malignancies, [27][28][29][30][31][32][33][34] including premalignant lesions of the upper aerodigestive tract 35 and colon. 36 Two studies evaluated the CCND1 G870A polymorphism in esophageal squamous cell carcinoma in the Chinese population.…”

Association of Cyclin D1 Variants with Head and Neck Cancer Susceptibility: Evidence from a Meta-analysis

“…However, 2 papers (Huang et al, 2006;Ye et al, 2008) were ruled out for the studies on premalignant lesion instead of cancer. As a result, 17 papers (Matthias et al, 1998;Zheng et al, 2001;Deng et al, 2002;Wong et al, 2003;Monteiro et al, 2004;Nishimoto et al, 2004;Holley et al, 2005;Catarino et al, 2006;Rydzanicz et al, 2006;Sathyan et al, 2006;Gomes et al, 2008;Marsit et al, 2008;Sui et al, 2009;Jelonek et al, 2010;Tsai et al, 2011;Shih et al, 2012;Sabir et al, 2013) comprising seventeen eligible studies with 3,761 cases and 3,834 controls for CCND1 G870A as well as three eligible studies (Sathyan et al, 2006;Tsai et al, 2011;Shih et al, 2012) with 943 cases and 935 controls for CCND1 G1722C were included. With regard to CCND1 G870A, seven studies (Matthias et al, 1998;Zheng et al, 2001;Monteiro et al, 2004;Holley et al, 2005;Catarino et al, 2006;Rydzanicz et al, 2006;Jelonek et al, 2010) were performed in Caucasians and seven (Deng et al, 2002;Wong et al, 2003;Sathyan et al, 2006;Sui et al, 2009;Tsai et al, 2011;Shih et al, 2012;Sabir et al, 2013) were conducted in Asians and three …”

“…With regard to CCND1 G870A, seven studies (Matthias et al, 1998;Zheng et al, 2001;Monteiro et al, 2004;Holley et al, 2005;Catarino et al, 2006;Rydzanicz et al, 2006;Jelonek et al, 2010) were performed in Caucasians and seven (Deng et al, 2002;Wong et al, 2003;Sathyan et al, 2006;Sui et al, 2009;Tsai et al, 2011;Shih et al, 2012;Sabir et al, 2013) were conducted in Asians and three (Nishimoto et al, 2004;Gomes et al, 2008;Marsit et al, 2008) for mixed population. Fifteen studies (Matthias et al, 1998;Deng et al, 2002;Wong et al, 2003;Monteiro et al, 2004;Nishimoto et al, 2004;Holley et al, 2005;Catarino et al, 2006;Rydzanicz et al, 2006;Sathyan et al, 2006;Gomes et al, 2008;Sui et al, 2009;Jelonek et al, 2010;Tsai et al, 2011;Shih et al, 2012;Sabir et al, 2013) were hospital-based and two studies (Zheng et DOI:http://dx.doi.org/10.7314/APJCP.2014.15.14.5645 Association of Cyclin D1 Variants with Head and Neck Cancer Susceptibility: Evidence from a Meta-analysis population-based. In addition, several studies had detailed genotype and allele frequencies under stratification of cancer site, gender, smoking status, alcohol drinking, T stage, histological differentiation and lymph nodes (Table 1 and Table 2).…”