Cyclic AMP Response to Epinephrine and Shock

McArdle, A. Hope; Chiu, Chu-Jeng; Hinchey, E. J.

doi:10.1001/archsurg.1975.01360090086017

Cited by 17 publications

(3 citation statements)

References 10 publications

(2 reference statements)

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“…As explanations for the reduced aggregation there may be considered the 'refractoriness of platelets' after limited in vivo action of ADP (7), the loss of aggregation-promoting agents of the platelets after thrombin action and endo peroxide or thromboxane A2 formation in vivo (15,19), the aggregationinhibiting effect of prostaglandin D2 formed in platelets (23), the elevated plasma cyclic AMP level (9,10,12) and the consequence o f acidosis (8,15).…”

Section: Discussionmentioning

confidence: 99%

Soluble Plasma Fibrin and Platelet Prostaglandin Endoperoxides following Myocardial Infarction

Matthias¹

1978

Pathophysiol Haemos Thromb

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Following myocardial infarction, soluble fibrin in plasma is often elevated as a sign of an activated plasmatic coagulation system. Soluble fibrin in plasma is most pronounced in shock patients under catecholamine administration. With the improvement of the clinical situation the fibrin concentration declines to normal. Following incubation with N-ethylmaleimide an increased production of prostaglandin endoperoxides is observed in the platelets of patients after myocardial infarction compared to normal platelets. Plasma of patients exhibits an endoperoxide-producing effect on normal platelets. The stimulating effect of patient plasma diminishes together with the fall of soluble plasma fibrin. These phenomena may be considered as signs of a relation between the plasmatic and throm-bocytic coagulation system.

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Section: Discussionmentioning

confidence: 99%

Soluble Plasma Fibrin and Platelet Prostaglandin Endoperoxides following Myocardial Infarction

Matthias¹

1978

Pathophysiol Haemos Thromb

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“…7], The effect appears to be due to interaction with [T-adrenoceptors and is imitated by syn thetic selective [T-adrenoceptor agonists [4], It is also known that plasma cyclic AMP lev els are elevated in several conditions which are characterized by high levels of circulating adrenaline, such as surgical trauma [10], hemorrhagic shock [3,9], hypoglycemia [6] and anaphylactic shock [5,12], It has been shown earlier that parturition is associated with increased levels of cyclic AMP in umbilical cord blood [13,14], In the present study we present evidence that the level of cyclic AMP in umbilical cord plasma is related to the degree of stress and to the concentration of catecholamines.…”

Section: Introductionmentioning

confidence: 99%

Cyclic 3′,5′-Adenosine Monophosphate in Umbilical Cord Blood of the Newborn Infant: Relation to Fetal Stress and Plasma Catecholamines

Bistoletti¹,

Bb²,

Lagercrantz³

1981

Neonatology

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Cyclic 3′,5′-adenosine monophosphate (cyclic AMP) was analyzed in the venous blood of the mothers and in the umbilical vein and artery of the infant at birth. In general, higher cyclic AMP levels were found in the umbilical vein than in the artery which were similar to the maternal values. Asphyxia and vacuum extraction were associated with significantly higher cyclic AMP levels, while the concentration was lower after elective cesarean sections than after uncomplicated vertex deliveries. The cyclic AMP concentrations were inversely correlated to pH and directly related to the catecholamine concentrations. The origin and possible significance of cyclic AMP in umbilical cord plasma is discussed.

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“…There exists a correlation between hormone binding level and adenyl cyclase activity within the hypophysis [10]. The mechanism of action of TTH at the thyroid cell level is likewise effected through adenyl cyclase activation, which activation is found to be reduced during shock [15]. In all three groups of patients, the most demonstrative changes were recorded in the level of T3, the hormone largely responsible for the biological effects of the thyroid [16,17].…”

Section: Discussionmentioning

confidence: 92%

Alterations in thyrotropic hormone, triiodothyronine, and thyroxine in patients presenting postoperative diffuse purulent peritonitis.

Hadzikostova¹,

Yoshikawa

Nicolov³

1989

J. Clin. Biochem. Nutr.

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SummaryThis is a clinical study covering 55 persons of male sex with ages ranging from 25 to 55 years. The patients were divided up into 3 groups as follows: Group A, operated on for perforating gastroduodenal ulcer where the postoperative period ran a course free of any complications (18 patients); Group B, operated on for gastroduodenal ulcer, complicated by postoperative diffuse purulent peritonitis, with a successful cure as a final outcome (16 patients); Group C, operated on for perforating gastroduodenal ulcer, complicated by postoperative diffuse purulent peritonitis, with lethal outcome (21 patients). In all groups under study assessment was made of the levels of thyrotropic hormone (TTH), triiodothyronine (T3), and thyroxine (T4) at 1, 3, and 5 days after laparotomy in Group A, and after relaparotomy in Groups B and C. In the patients of Group A, the dynamic changes in TTH, T3, and T4 levels disclosed values within normal limits. In Group B, the levels of TTH and T4 were within normal limits, while T3 showed a low value during the first and third day, reaching the lowermost limit of the norm on the fifth day. In the patients of Group C, inhibition of the entire thyrotropinthyroid axis was observed: TTH, T3, and T4 levels fell abruptly, with the change in T3 being the most significant. These results suggest that the thyroid hormones may be related to these pathological conditions and that these hormones may be a good indicator for the prognosis of peritonitis.

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Cyclic AMP Response to Epinephrine and Shock

Cited by 17 publications

References 10 publications

Soluble Plasma Fibrin and Platelet Prostaglandin Endoperoxides following Myocardial Infarction

Soluble Plasma Fibrin and Platelet Prostaglandin Endoperoxides following Myocardial Infarction

Cyclic 3′,5′-Adenosine Monophosphate in Umbilical Cord Blood of the Newborn Infant: Relation to Fetal Stress and Plasma Catecholamines

Alterations in thyrotropic hormone, triiodothyronine, and thyroxine in patients presenting postoperative diffuse purulent peritonitis.

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