Soluble Plasma Fibrin and Platelet Prostaglandin Endoperoxides following Myocardial Infarction

Abstract

Following myocardial infarction, soluble fibrin in plasma is often elevated as a sign of an activated plasmatic coagulation system. Soluble fibrin in plasma is most pronounced in shock patients under catecholamine administration. With the improvement of the clinical situation the fibrin concentration declines to normal. Following incubation with N-ethylmaleimide an increased production of prostaglandin endoperoxides is observed in the platelets of patients after myocardial infarction compared to normal platelets. Plasma of patients exhibits an endoperoxide-producing effect on normal platelets. The stimulating effect of patient plasma diminishes together with the fall of soluble plasma fibrin. These phenomena may be considered as signs of a relation between the plasmatic and throm-bocytic coagulation system.

Changes in Platelet Functions, Coagulation and Fibrinolysis in Uncomplicated Cases of Acute Myocardial Infarction

“…Our findings fit well with the results described by Matthias (1978), who showed that plasma from patients with AMI possessed an endoperoxide-producing effect on normal platelets contemporaneous with the presence of soluble fibrin in the patients' plasma.…”

Platelet Heterogeneity

“…1,77i430 T valuable indicator of prostaglandin synthesis (Okuma et a1 1971, Smith et a1 1976), so we could deduce that heavy-large plate lets synthetize more prostaglandins than light-small ones. These data are in accordance with the increased aggregability found (Abbate et a1 1977, Mathias 1978 and with their higher enzymatic content (Petschow et al 1974, Friedhof et al 1978.…”