Cycle to cycle adaptive control of simulated moving bed chromatographic separation processes

Suvarov, Paul; Kienle, Achim; Wouwer, Alain Vande; Weireld, Guy De; Nobre, Clarisse

doi:10.1016/j.jprocont.2013.11.001

Cited by 32 publications

(14 citation statements)

References 24 publications

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“…In our future work, we also intend to use the CE/SE method for model-based control of binary and ternary SMB processes following the approach in [31][32][33].…”

Section: Resultsmentioning

confidence: 99%

Efficient Simulation of Chromatographic Processes Using the Conservation Element/Solution Element Method

2020

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Chromatographic separation processes need efficient simulation methods, especially for nonlinear adsorption isotherms such as the Langmuir isotherms which imply the formation of concentration shocks. The focus of this paper is on the space–time conservation element/solution element (CE/SE) method. This is an explicit method for the solution of systems of partial differential equations. Numerical stability of this method is guaranteed when the Courant–Friedrichs–Lewy condition is satisfied. To investigate the accuracy and efficiency of this method, it is compared with the classical cell model, which corresponds to a first-order finite volume discretization using a method of lines approach (MOL). The evaluation is done for different models, including the ideal equilibrium model and a mass transfer model for different adsorption isotherms—including linear and nonlinear Langmuir isotherms—and for different chromatographic processes from single-column operation to more sophisticated simulated moving bed (SMB) processes for the separation of binary and ternary mixtures. The results clearly show that CE/SE outperforms MOL in terms of computational times for all considered cases, ranging from 11-fold for the case with linear isotherm to 350-fold for the most complicated case with ternary center-cut eight-zone SMB with Langmuir isotherms, and it could be successfully applied for the optimization and control studies of such processes.

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“…In our future work, we also intend to use the CE/SE method for model-based control of binary and ternary SMB processes following the approach in [31][32][33].…”

Section: Resultsmentioning

confidence: 99%

Efficient Simulation of Chromatographic Processes Using the Conservation Element/Solution Element Method

2020

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“…The linear isotherm model and the Langmuir isotherm model generally used for the adsorption of a solute in liquid solution , were tested to determine the best fit of the experimental data. The mathematical models are expressed in Eqs.…”

Section: Modeling Of the Separation Process In A Chromatographic Columnmentioning

confidence: 99%

Competitive effect of glucose–fructose adsorption in a fixed‐bed chromatographic column

Tangpromphan

Kaewchada

Jaree

2016

J of Separation Science

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A continuous separation system such as a simulated moving-bed process requires adsorption data with precise equilibrium and kinetic model parameters of a single chromatographic column. The adsorption of glucose and fructose in a fixed-bed chromatographic column was investigated to determine the competition effect of each component resulting from their initial molar ratios. The model parameters including bed porosity and axial dispersion coefficient were determined using the moment analysis method. The equilibrium isotherm parameters were estimated by conducting experiments at various molar ratios and initial sugar concentrations. The parameters obtained were then used for the simulation of dynamic breakthrough curves of glucose and fructose. The equilibrium isotherms revealed that the linear adsorption pattern provided good prediction for each molar ratio using the Henry equation. In addition, the modified Langmuir model was proposed to account for the competitive adsorption, due to the cooperative competition effect whereby glucose was promoted to the active sites by fructose to a greater degree than vice versa. A good agreement between the experimental and numerical data of the adsorption time profiles was also observed.

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“…Numerous studies have been focused on the development of downstream treatments to purify FOS from sugar mixtures, such as the use of membrane techniques, chromatographic methods and microbial treatment using successive purification fermentations (Nobre, Teixeira, & Rodrigues, 2012;Nobre et al, 2016;Suvarov, Kienle, Nobre, De Weireld, & Vande Wouwer, 2014;Yang, Wang, Teng, & Zhang, 2008). Alternatively, FOS have been simultaneously produced and purified by mixtures of enzymes e.g.…”

Section: Introductionmentioning

confidence: 99%

One-step co-culture fermentation strategy to produce high-content fructo-oligosaccharides

Nobre

Gonçalves

Teixeira

et al. 2018

Carbohydrate Polymers

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An integrated process enabling the simultaneous production and purification of fructo-oligosaccharides (FOS) was explored. A co-culture fermentation with Aspergillus ibericus (used as FOS producer strain) and Saccharomyces cerevisiae YIL162 W (for small saccharides removal) was optimized. Inoculation conditions of S. cerevisiae, fermentative broth composition, temperature and pH were optimized by experimental design. Yeast extract concentration and temperature were the most significant variables affecting FOS purity. Co-culture fermentations with simultaneously inoculation of the strains, run under 30 °C, initial pH 6.0 and 17 g L yeast extract led to FOS mixtures with 97.4 ± 0.2% (w/w) purity. The fermentations conducted in bioreactor, at a 0.8 vvm aeration rate, yielded 0.70 ± 0.00 g.g at 45 h fermentation, with a FOS content of 133.7 ± 0.1 g L. A purity of FOS up to 93.8 ± 0.7% (w/w) was achieved. The one-step fermentation proved to be efficient, economical and fast.

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Cycle to cycle adaptive control of simulated moving bed chromatographic separation processes

Cited by 32 publications

References 24 publications

Efficient Simulation of Chromatographic Processes Using the Conservation Element/Solution Element Method

Efficient Simulation of Chromatographic Processes Using the Conservation Element/Solution Element Method

Competitive effect of glucose–fructose adsorption in a fixed‐bed chromatographic column

One-step co-culture fermentation strategy to produce high-content fructo-oligosaccharides

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