CyberKnife Radiosurgery for the Treatment of Intraocular and Periocular Lymphoma

Bianciotto, Carlos; Shields, Carol L.; Lally, Sara E.; Freire, Jorge E.; Shields, Jerry A.

doi:10.1001/archophthalmol.2010.283

Cited by 26 publications

(10 citation statements)

References 54 publications

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“…with doses between 13.5 and 22.5 Gy in 3 to 5 fractions. A complete response was noted in all of the 13 patients reported, after a mean follow-up of 23 months, with only one patient developing cataract after the treatment [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Single-fraction low-energy electronic brachytherapy for conjunctival lymphoma

Cabrera

Buitrago

Fuentes

et al. 2020

jcb

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Purpose Conjunctival lymphoma represents an uncommon tumor, accounting for 5-10% of total extranodal lymphomas. Although radiotherapy is a frequent treatment option, limited capacities and lack of specialized centers are common problems in Peru, forcing radiation oncologists to apply short courses of radiotherapy. Here, we report a case series of patients treated with a novel single-shot scheme. Additionally, we present a literature review of the current short-course irradiation strategies. Cases presentation Three cases of conjunctival marginal zone (B-cell) lymphoma (marginal zone lymphoma [MZL]/mucosa-associated lymphoid tissue [MALT]) of the fornix are presented. Following biopsy and sonographic assessment of the lesion thickness, we applied a focused single dose of 14 Gy kilovoltage brachytherapy (prescribed to the maximum thickness of the lesion). Follow-up was scheduled in quarterly intervals. After 28, 31, and 40 months of follow-up, none of the three patients treated exhibited acute or chronic toxicities and remained local or distant disease-free. Conclusions Single dose kilovoltage brachytherapy was effective and safe in this small cohort of patients. Based on the literature, there is an evidence that local treatment in short-course radiotherapy is effective and should be considered amongst therapeutic options for these patients; however, this novel approach should be evaluated prospectively in a larger cohort.

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Section: Discussionmentioning

confidence: 99%

Single-fraction low-energy electronic brachytherapy for conjunctival lymphoma

Cabrera

Buitrago

Fuentes

et al. 2020

jcb

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“…The literature for such patients is more scant. A recent study by Bianciatto et al showed a 100% local control rate in 13 patients with ocular lymphomas of several different histopathologies treated with CyberKnife with a mean follow-up time of 23 months [22]. External radiation techniques continue to evolve, using intensity modulation and more sophisticated means of tumor targeting, blurring the lines between what is stereotactic radiosurgery and external radiation.…”

Section: Discussionmentioning

confidence: 99%

Experience using frameless fractionated radiosurgery for the treatment of orbital and ocular tumors

Morales

Lamond²,

Lally

et al. 2012

J Radiat Oncol

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Objective This study analyzes patients with orbital tumors who were treated with fractionated stereotactic radiosurgery to help maximize local control after surgery, or to more expeditiously treat radiosensitive tumors and palliative cases. Materials and methods Thirty-one patients with tumors of the eye, orbit, or eyelid were treated using CyberKnife radiosurgery from June 2006 to June 2009. The 23 patients with at least 12 months of follow-up are included in this analysis. All patients had aquaplast mask immobilization with bolus if necessary. CT and MRI images were acquired and fused for treatment planning. Tumor contour and treatment planning was jointly performed by a radiation oncologist, ocular oncologist, and medical physicist. Total doses were lower for radiosensitive tumors (13.5-20 Gy in four to five fractions) than non-radiosensitive tumors (15-35 Gy in three to five fractions). Each fraction was delivered in 30-60 min with all treatments being delivered over 1-2 weeks. Patient ages ranged from 16 to 91 years old with a median age of 67. The majority (21 of 23) were treated with curative intent, including 9 radiosensitive tumors (all lymphomas), 17 with intact eye following limited surgery, and 3 after exenteration. Palliative patients included one metastasis and one lymphoma. Results At a median overall follow-up of 34 months (range, 13-42 months), 21 patients (91%) exhibited local control. Complications included neovascular glaucoma (n=3), chronic dry eye (n=1), and osteomyelitis (n=1). Conclusion Fractionated radiosurgery provided good local control with a low risk of side effects. Ocular oncology participation in target and normal tissue delineation was felt to be an important component of the treatment planning process.

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“…However, with linac-based stereotactic radiosurgery, treatment is delivered with a linac and there is no radioactive source. Both standard linear accelerators and CyberKnife linear accelerators have are used in the delivery of stereotactic radiotherapy as part of the management of ophthalmologic malignancies [43][44][45].…”

Section: Linear Accelerator-based Stereotactic Radiosurgerymentioning

confidence: 99%

Teletherapy: Advanced Techniques

Stockham

Balagamwala

Singh

et al. 2013

Ophthalmic Radiation Therapy

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Radiotherapy has been utilized as a treatment for ophthalmologic processes for more than one hundred years. Over this century, the field of ophthalmologic oncology has been revolutionized through medical discoveries, development of novel surgical interventions, and innovation of advanced radiotherapy techniques. In this chapter, novel radiotherapy techniques are considered. Material presented will build on basic radiation therapy principles, techniques, and treatment parameters established in the previous chapter through consideration of intensity modulated radiotherapy, stereotactic radiotherapy, and heavy ion therapy. Deliberation of matters common across advanced radiotherapy techniques including target delineation, treatment planning, and requisites for ensuring accurate, precise treatment delivery will precede discussion of advanced radiotherapy techniques as applied to the management ophthalmologic malignancies.

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CyberKnife Radiosurgery for the Treatment of Intraocular and Periocular Lymphoma

Cited by 26 publications

References 54 publications

Single-fraction low-energy electronic brachytherapy for conjunctival lymphoma

Single-fraction low-energy electronic brachytherapy for conjunctival lymphoma

Experience using frameless fractionated radiosurgery for the treatment of orbital and ocular tumors

Teletherapy: Advanced Techniques

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