Cyanobacterial peptides with respect to anticancer activity: Structural and functional perspective

Ahmad, Iffat Zareen; Parvez, Sidrah; Tabassum, Heena

doi:10.1016/b978-0-12-819483-6.00010-2

Cited by 5 publications

(4 citation statements)

References 96 publications

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“…Lyngbyabellins are a type of peptolide found in various marine cyanobacteria genera, including Moorea and Okeanea [ 39 ]. Lyngbyabellins have been reported to possess anticancer properties against various cancer cell lines [ 40 ]. A study isolated ten lyngbyabellin compounds (lyngbyabellin G, lyngbyabellin O, lyngbyabellin P, lyngbyabellin H, 27-deoxylyngbyabellin A, R=H, homohydroxydolabellin, and lyngbyabellin A, R=OH) from Malaysian Moorea bouillonii and Red Sea Okeania sp., and the isolated compounds were tested for their cytotoxic activity against human breast cancer cells (MCF7).…”

Section: Bioactive Properties Reported From Marine Cyanobacteriamentioning

confidence: 99%

Recent Reports on Bioactive Compounds from Marine Cyanobacteria in Relation to Human Health Applications

Perera

Herath

Sanjeewa

et al. 2023

Life

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The ocean is a valuable natural resource that contains numerous biologically active compounds with various bioactivities. The marine environment comprises unexplored sources that can be utilized to isolate novel compounds with bioactive properties. Marine cyanobacteria are an excellent source of bioactive compounds that have applications in human health, biofuel, cosmetics, and bioremediation. These cyanobacteria exhibit bioactive properties such as anti-inflammatory, anti-cancer, anti-bacterial, anti-parasitic, anti-diabetic, anti-viral, antioxidant, anti-aging, and anti-obesity effects, making them promising candidates for drug development. In recent decades, researchers have focused on isolating novel bioactive compounds from different marine cyanobacteria species for the development of therapeutics for various diseases that affect human health. This review provides an update on recent studies that explore the bioactive properties of marine cyanobacteria, with a particular focus on their potential use in human health applications.

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Section: Bioactive Properties Reported From Marine Cyanobacteriamentioning

confidence: 99%

Recent Reports on Bioactive Compounds from Marine Cyanobacteria in Relation to Human Health Applications

Perera

Herath

Sanjeewa

et al. 2023

Life

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“…These depsipeptides, especially grassypeptolides F and G, were originally isolated from Lyngbya spp., whereas grassypeptolides D and E were derived from Leptolyngbya spp. [ 77 ]. They constitute a group of 31-membered macrocyclic depsipeptides with high D-amino acid content, one beta-amino acid, and two thiazolines [ 36 ].…”

Section: Depsipeptides With a Recognized Mechanism Of Targeting Cance...mentioning

confidence: 99%

“…Specifically, they can induce apoptosis in cancer cells [ 83 ]. In particular, hantupeptin A, a 19-membered cyclic depsipeptide, has shown potent cytotoxicity against breast cancer (MCF-7) and leukemia cells (MOLT-4) [ 21 ], while hantupeptins B and C have exhibited a more modest cytotoxic effect on the same cells [ 77 ].…”

Section: Depsipeptides With a Recognized Mechanism Of Targeting Cance...mentioning

confidence: 99%

Depsipeptides Targeting Tumor Cells: Milestones from In Vitro to Clinical Trials

2023

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Cancer is currently considered one of the most threatening diseases worldwide. Diet could be one of the factors that can be enhanced to comprehensively address a cancer patient’s condition. Unfortunately, most molecules capable of targeting cancer cells are found in uncommon food sources. Among them, depsipeptides have emerged as one of the most reliable choices for cancer treatment. These cyclic amino acid oligomers, with one or more subunits replaced by a hydroxylated carboxylic acid resulting in one lactone bond in a core ring, have broadly proven their cancer-targeting efficacy, some even reaching clinical trials and being commercialized as “anticancer” drugs. This review aimed to describe these depsipeptides, their reported amino acid sequences, determined structure, and the specific mechanism by which they target tumor cells including apoptosis, oncosis, and elastase inhibition, among others. Furthermore, we have delved into state-of-the-art in vivo and clinical trials, current methods for purification and synthesis, and the recognized disadvantages of these molecules. The information collated in this review can help researchers decide whether these molecules should be incorporated into functional foods in the near future.

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“…The peptide apratoxin E was also isolated from L. bouillonii , and was found to bear superior cytotoxicity when compared to its closest analog, the semi-synthetic E-dehydroapratoxin A, against various cancer cell-lines derived from bone, colon, and cervix, with ranging values of activity but less active when compared to Apratoxin A [ 20 ]. Apratoxins F and G are two cytotoxic cyclic depsipeptides which were isolated from Lyngbya bouillonii collected from Palmyra, characterized by the presence of an N-methyl alanine residue at a position where earlier Apratoxins contained a proline unit [ 21 , 22 ]. Graphical sketches of the molecular structures of the Apratoxins A–G as retrieved from the PubChem database ( (accessed on 22 February 2022)) are shown in Figure 1 .…”

Section: Introductionmentioning

confidence: 99%

Virtual Prospection of Marine Cyclopeptides as Therapeutics by Means of Conceptual DFT and Computational ADMET

2022

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Bioactive peptides are chemical compounds created through the covalent bonding of amino acids, known as amide or peptide bonds. Due to their unusual chemistry and various biological effects, marine bioactive peptides have garnered considerable research. The effectiveness of a bioactive marine peptide is attributed to its structural features, such as amino acid content and sequence, which vary depending on the degree of action. Cyclic peptides combine several favorable properties such as good binding affinity, target selectivity and low toxicity that render them an attractive modality for the development of therapeutics. The apratoxins are a class of molecules formed by a series of cyclic depsipeptides with potent cytotoxic activities. The objective of this research is to pursue a computational prospection of the molecular structures and properties of several cylopeptides of marine origin with potential therapeutic applications. The methodology will be based on the determination of the chemical reactivity descriptors of the studied molecules through the consideration of the Conceptual DFT model and validation of a particular model chemistry, MN12SX/Def2TZVP/H2O. These studies will be complemented by a determination of the pharmacokinetics and ADMET parameters by resorting to certain cheminformatics tools.

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Cyanobacterial peptides with respect to anticancer activity: Structural and functional perspective

Cited by 5 publications

References 96 publications

Recent Reports on Bioactive Compounds from Marine Cyanobacteria in Relation to Human Health Applications

Recent Reports on Bioactive Compounds from Marine Cyanobacteria in Relation to Human Health Applications

Depsipeptides Targeting Tumor Cells: Milestones from In Vitro to Clinical Trials

Virtual Prospection of Marine Cyclopeptides as Therapeutics by Means of Conceptual DFT and Computational ADMET

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