Cyanoacetamides and their thio- and selenocarbonyl analogues as promising reagents for fine organic synthesis

Abstract

Published data on the use of cyanoacetamides, cyanothio-and -selenoacetamides in fine organic synthesis and the prospects of application of these compounds in combinatorial synthesis are analysed and generalised. The bibliography includes 653 references.

A review on the development of urease inhibitors as antimicrobial agents against pathogenic bacteria

“…Motivated by broad spectrum of biological and pharmaceutical applications of cyano acetamide derivatives [135] , [136] , [137] , [138] , [139] , [140] , [141] , [142] , [143] , in 2015, Qureshi et al screened several compounds based on this moiety ( Scheme 47 ) to continue determine their urease inhibitory activity [144] and continue previous studies of urease inhibitors [133] , [134] . According to the authors, the high urease inhibitory activity potentially resulted from the extra interaction of the furan and thiophene ring with the urease nickel center.…”

Synthesis and luminescent properties and theoretical investigation on electronic structure of nitrile-based 2-pyridone molecules

“…Many synthesis methods of 2-pyrone have been reported to date [8], e.g. oxidation of a N-substituted pyridinium salt [9], and Knovenagel-type reactions [10] such as cyclocondensation of ketene dithioacetals with compounds containing active methylene group like cyanoacetamide. Most of earlier reported methods for the synthesis of 2-pyridones involving the condensation of 1,3-binucleophiles with cyanoacetamide need strong bases like sodium hydride, sodium hydroxide or alkoxides [11].…”

Synthesis of 3-(4-chlorophenyl)oxirane-2,2-dicarboxamide

“…6 Proceeding further in our investigations of the chemistry of cyanothioacetamide, 7 we studied peroxida tion of arylmethylidene(cyano)thioacetamides. These easily accessible compounds are of interest because of the presence of several oxidizable fragments: the thioamide group, the cyano group, and the activated double bond.…”