Cyanidin-3-Glucoside-Rich Extract from Chinese Bayberry Fruit Protects Pancreatic β Cells and Ameliorates Hyperglycemia in Streptozotocin-Induced Diabetic Mice

Sun, Chongde; Zhang, Bo; Zhang, Jiukai; Xu, Chang-Jie; Wu, Yulian; Li, Xian; Chen, Kunsong

doi:10.1089/jmf.2011.1806

Cited by 107 publications

(87 citation statements)

References 37 publications

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“…Administration of Chinese bayberry fruit extracts (150 g of cyanidin-3-glucoside/10 g of body weight-twice per day) significantly reduced fasting blood glucose and increased the oral glucose tolerance in streptozotocin-induced diabetic mice model (P < 0.05) [23] (Table 2). An in vitro evaluation of Chinese bayberry fruit suggested protective effects against oxidative stress-induced injury in pancreatic ␤-cells.…”

Section: Enhancing Pancreatic β-Cell Function: Modification Of Oxidatmentioning

confidence: 98%

“…Grace et al [35] Maqui berry Diabetic rat model with chronic feeding of Sun et al [23] sensitivity over 6 wk in obese, nondiabetic, and insulin-resistant participants (p < 0.05, Table 1). Authors were unable to demonstrate any possible mechanistic explanation since inflammatory markers investigated were not significantly different compared to the placebo group [33].…”

Section: Enhancing Peripheral Tissue Insulin Sensitivity: Modificatiomentioning

confidence: 99%

“…Pretreatment of pancreatic ␤-cells with bayberry fruit extracts (containing 0.5 mol/L cyanidin-3-glucoside) prevented cell death, increased cellular viability, and decreased mitochondrial reactive oxygen species production and cell necrosis induced by H 2 O 2 (800 or 1,200 mol/L). Furthermore, they observed that bayberry fruit extracts dosedependently up-regulated pancreatic duodenal homeobox 1 gene expression, contributing to increased insulin-like growth factor II gene transcript levels and insulin protein in INS-1 cell [23] (Table 3). Bayberry extracts have been shown to prevent H 2 O 2 induced cell injury via ERK1/2-and PI3K/Akt-mediated HO-1 upregulation in vitro in pancreatic ␤-cells [24].…”

Section: Enhancing Pancreatic β-Cell Function: Modification Of Oxidatmentioning

confidence: 99%

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Anti-diabetic actions of Berry polyphenols – Review on proposed mechanisms of action

Edirisinghe

Burton‐Freeman

2016

JBR

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Abstract. The incidence of type 2 diabetes mellitus (T2DM) has reached near-epidemic proportions in the Western world with other parts of the world following close behind. Glycemic control is paramount in type 1 diabetes mellitus (T1DM) and T2DM. Berries may beneficially influence glycemic control through the action of their polyphenolic components. While clinical studies on the anti-diabetic effects of berry polyphenols are limited, epidemiological data have indicated favorable effects of berry/anthocyanins intake on development and/or management of T2DM. Furthermore, data derived from in vivo animal studies and in vitro cell culture models are promising. Various molecular targets and modulation of cell signaling pathways in pancreatic ␤-cells, hepatocytes, adipocytes, and skeletal muscle cells are among the proposed mechanisms for berry polyphenols and their metabolites' action. Berry polyphenols may exert anti-diabetic effects by (i) enhancing insulin production and reducing apoptosis and promoting proliferation of pancreatic ␤-cells, (ii) regulating glucose metabolism by interfering with absorption or by increasing peripheral tissue glucose uptake through insulin receptor-dependent or independent mechanisms via modification of oxidative stress, inflammation or perceived energy status of cell. This mini review discusses recent findings from our laboratory and other studies on the anti-diabetic effects of berry polyphenolic compounds with special emphasis on the cellular and molecular mechanisms involved in the beneficial effects of berry polyphenol compounds.

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Section: Enhancing Pancreatic β-Cell Function: Modification Of Oxidatmentioning

confidence: 98%

Section: Enhancing Peripheral Tissue Insulin Sensitivity: Modificatiomentioning

confidence: 99%

Section: Enhancing Pancreatic β-Cell Function: Modification Of Oxidatmentioning

confidence: 99%

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Anti-diabetic actions of Berry polyphenols – Review on proposed mechanisms of action

Edirisinghe

Burton‐Freeman

2016

JBR

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“…The molecular formula of C3G is C21H21O11+, and its molar mass is 449.3843 g/mol. C3G has the ability to stimulate insulin secretion from pancreatic cells in the presence of 4 mM or 10 mM glucose [25] and has also been reported to have anti-inflammatory and antioxidant effects [8,28]. Despite these studies, there is no experimental data demonstrating a relationship between postprandial blood glucose levels and C3G.…”

Section: Introductionmentioning

confidence: 99%

Cyanidin-3-O-glucoside Ameliorates Postprandial Hyperglycemia in Diabetic Mice

Choi¹,

Choi²,

Park³

et al. 2017

Journal of Life Science

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Cyanidin-3-O-glucoside (C3G) shows anti-inflammatory and antioxidant effects; however, its effect on postprandial blood glucose levels remains unknown. Alpha-glucosidase inhibitors regulate postprandial hyperglycemia by impeding carbohydrate digestion in the small intestine. Here, the effect of C3G on α-glucosidase and α-amylase inhibition and its ability to ameliorate postprandial hyperglycemia in streptozotocin (STZ)-induced diabetic mice were evaluated. ICR normal and STZ-induced diabetic mice were orally administered soluble starch alone or with C3G or acarbose. The half-maximal inhibitory concentrations of C3G for α-glucosidase and α-amylase were 13.72 and 7.5 μM, respectively, suggesting that C3G was more effective than acarbose. The increase in postprandial blood glucose levels was more significantly reduced in the C3G groups than in the control group for both diabetic and normal mice. The area under the curve for the diabetic mice was significantly reduced following C3G administration. C3G may be a potent α-glucosidase inhibitor and may delay dietary carbohydrate absorption.

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“…Revelation of the physiological functions of flavonoids of black soybean may contribute to consumption of black soybean, an increase in the income of farm producers, and a consequent stabilization of the agricultural industry. These flavonoids are minor nutrients but considered potent natural scavengers of reactive oxygen species (ROS) (2) and have been shown to reduce the risk of liver injury (3), improve blood pressure (4) and ameliorate metabolic abnormalities (5,6), which are often related to oxidative stress. Additionally, anthocyanin from black soybean prevented oxidative stress in neurocytes in vitro (7,8).…”

mentioning

confidence: 99%

Black Soybean Seed Coat Extract Prevents Hydrogen Peroxide-Mediated Cell Death via Extracellular Signal-Related Kinase Signalling in HepG2 Cells

Hashimoto

Oki

Sasaki

et al. 2015

J Nutr Sci Vitaminol

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Summary Oxidative stress reduces cell viability and contributes to disease processes. Flavonoids including anthocyanins and proanthocyanidins reportedly induce intracellular antioxidant defence systems. Thus, in this study, we examined the antioxidant effects of a commercial extract from black soybean seed coats (BE), which are rich in anthocyanin and proanthocyanidin, and investigated the associated intracellular mechanisms in HepG2 cells. HepG2 cells treated with hydrogen peroxide (HPO) showed 60% viability, whereas pretreatment with BE-containing media for 2 h ameliorated HPO-mediated cell death by up to 90%. Pretreatment with BE for 2 h partially blocked HPO-mediated activation of ERK in HepG2 cells, and that for 1 h led to a 20% increase in intracellular total protein phosphatase (PP) activity, which is known to deactivate protein kinases. These results indicate that BE prevents HPO-mediated cell damage by inhibiting ERK signalling, potentially via PPs.

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Cyanidin-3-Glucoside-Rich Extract from Chinese Bayberry Fruit Protects Pancreatic β Cells and Ameliorates Hyperglycemia in Streptozotocin-Induced Diabetic Mice

Cited by 107 publications

References 37 publications

Anti-diabetic actions of Berry polyphenols – Review on proposed mechanisms of action

Anti-diabetic actions of Berry polyphenols – Review on proposed mechanisms of action

Cyanidin-3-O-glucoside Ameliorates Postprandial Hyperglycemia in Diabetic Mice

Black Soybean Seed Coat Extract Prevents Hydrogen Peroxide-Mediated Cell Death via Extracellular Signal-Related Kinase Signalling in HepG2 Cells

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