Cyanide Antidotes for Mass Casualties: Water-Soluble Salts of the Dithiane (Sulfanegen) from 3-Mercaptopyruvate for Intramuscular Administration

Patterson, Steven; Monteil, Alexandre R.; Cohen, Jonathan F.; Crankshaw, Daune L.; Vince, Robert; Nagasawa, Hiromichi

doi:10.1021/jm301633x

Cited by 28 publications

(38 citation statements)

References 15 publications

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“…Thiosulfateacts as a sulfur donor for the endogenous cyanide metabolizing enzyme, rhodanese. Sulfanegentriethanolaminetoo acts by improving the efficiency of endogenous cyanide detoxifying enzyme pathways [27]. 3-Mercaptopyruvate acts as a substrate for the enzyme endogenous cyanide detoxifying enzyme 3-MPST [28].…”

Section: Discussionmentioning

confidence: 99%

Awareness, among primary health care physicians, of acute cyanide poisoning being a possible consequence of fire accidents

Sood

Khandalkar

Sood³

2016

Int J of Biomed & Adv Res

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Objectives: To discern the degree of awareness amongst the primary health care physicians about the fact that cyanide poisoning is a possible consequence of fire accidents. Methods: Using an anonymous questionnaire, thirty allopath primary health care physicians were tested for awareness of acute cyanide poisoning being a possible consequence of fire accidents. Results: Only one (3%) of the physicians was aware of the possibility of acute cyanide poisoning due to fire accidents. Conclusions: We report dismal awareness among the primary health care physicians. Medical education curriculum must cater for emerging healthcare issues.

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Section: Discussionmentioning

confidence: 99%

Awareness, among primary health care physicians, of acute cyanide poisoning being a possible consequence of fire accidents

Sood

Khandalkar

Sood³

2016

Int J of Biomed & Adv Res

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“…Subsequently, electrons from the reduction of energy substrates react with the accumulated oxygen to form ROS in the mitochondria matrix (Menna- Barreto & de Castro, 2014;Patterson et al, 2014). Mitochondrial radical scavenger GSH regulates the conversion of oxygen to ROS and the NO cycle in the mitochondria, thus the rate of production of GSH is proportional to the rate of ROS/NO production (Aon et al, 2010;Leirós et al, 2014).…”

Section: Oxygen-dependent Ros Productionmentioning

confidence: 99%

Differential oxidative stress thresholds distinguishes cellular response to vascular occlusion and chemotoxicityin vivo

Ogundele

Balogun

Cobham

et al. 2016

Drug and Chemical Toxicology

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Although CN and VO induced oxidative stress through ROS production, our findings suggest a difference in the threshold of ROS production and cytotoxicity for both forms of ischemia. However, this threshold is dependent on the availability of oxygen to fuel mitochondria-ROS production in oxidative stress. Ultimately, the difference in oxygen availability in vivo determined the significance of lipid peroxidation, calcium-shift and autophagic cell response associated with the ischemia. CN treatment generated more ROS and was associated with prominent cellular changes when compared with VO.

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“…As mentioned above, there are literature precedents for the cation in 3 and an analysis of these reveals significant conformational flexibility in their molecular structures. Indeed, there are 10 other cations in structures that have three-dimensional coordinates and that do not suffer from disorder [38][39][40][41][42][43][44][45]. Key torsion angle data for these are collected in Table 2.…”

Section: Molecular Structures Of the Cations In 1-3mentioning

confidence: 99%

Three ammonium salts of sulfathiazole: crystallography and anti-microbial assay

Aznan

Abdullah

Khoo

et al. 2015

Zeitschrift Für Kristallographie - Crystalline Materials

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The crystal and molecular structures of three ammonium salts derived from sulfathiazole are described. In each case, the anion is in the azanide form, features an intramolecular S←O interaction, and adopts a U-shape. The structures of two cations, [R(HOCH 2 CH 2 )NH 2 ] + , namely for R = Me (1) and iPr (2), are unprecedented in the crystallographic literature. Extensive hydrogen bonding is observed in all crystal structures and leads to a two-dimensional array for 1, and three-dimensional architectures for each of 2 and 3 (R = CH 2 CH 2 OH). The salts exhibited anti-microbial activity against a range of Gram-positive and Gram-negative bacteria, and proved bactericidal toward Vibrio parahaemolyticus, but had no advantage over sulfathiazole itself.

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Cyanide Antidotes for Mass Casualties: Water-Soluble Salts of the Dithiane (Sulfanegen) from 3-Mercaptopyruvate for Intramuscular Administration

Cited by 28 publications

References 15 publications

Awareness, among primary health care physicians, of acute cyanide poisoning being a possible consequence of fire accidents

Awareness, among primary health care physicians, of acute cyanide poisoning being a possible consequence of fire accidents

Differential oxidative stress thresholds distinguishes cellular response to vascular occlusion and chemotoxicityin vivo

Three ammonium salts of sulfathiazole: crystallography and anti-microbial assay

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