CXCR4/CXCL12 expression profile is associated with tumor microenvironment and clinical outcome of liver metastases of colorectal cancer

Sakai, Nozomu; Yoshidome, Hiroyuki; Sugiyama, Takashi; Kimura, Fumio; Shimizu, Hiroaki; Ohtsuka, Masayuki; Takeuchi, Dan; Sakakibara, Masahiro; Miyazaki, Masaru

doi:10.1007/s10585-011-9433-5

Cited by 38 publications

(32 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Chemokines and their receptors, can be used by cancer cells in order to modulate the host microenvironment and also ease cancer progression [82,83]. Chemokines and their receptors have been shown to regulate various metastatic and advanced cancers, with interleukin-8 (IL-8) and its receptor CXCR2 being two of the most significantly upregulated chemokines in colon cancer [84].…”

Section: Cxcr4/cxcl12 Axis and The Crlm Pathwaymentioning

confidence: 99%

“…CXCR4, an established inducer of colorectal cancer progression, has been found to be significantly higher in liver metastases than in primary colorectal cancer [82,85]. The CXCR4 ligand, CXCL12/stromal-derived factor-1 (SDF-1), is also linked to tumour progression and accumulates in CD133-positive tumour cells [86][87][88]; the hypothesis is that there is interaction between CXCR4 and CXCL12 expression, highlighting this as causing tumours to proliferate, migrate, and invade other organs.…”

Section: Cxcr4/cxcl12 Axis and The Crlm Pathwaymentioning

confidence: 99%

“…The CXCR4 ligand, CXCL12/stromal-derived factor-1 (SDF-1), is also linked to tumour progression and accumulates in CD133-positive tumour cells [86][87][88]; the hypothesis is that there is interaction between CXCR4 and CXCL12 expression, highlighting this as causing tumours to proliferate, migrate, and invade other organs. Sakai et al reported that increased levels of nuclear CXCR4 and hepatocyte CXCL12 expression are associated with overall and liver-disease free survival, when compared with other clinical factors [82]. Additionally, CXCR4 and CXCL12 expression profiles could be a predictor of remnant liver cancer recurrence and of poor prognosis.…”

Section: Cxcr4/cxcl12 Axis and The Crlm Pathwaymentioning

confidence: 99%

“…Additionally, CXCR4 and CXCL12 expression profiles could be a predictor of remnant liver cancer recurrence and of poor prognosis. Sakai et al concluded that CXCR4/CXCL12 ratio could have an important role in the biologically aggressive behaviour of colorectal liver metastasis, indicating that CXCR4 expression in colorectal liver metastases together with CXCL12 upregulation in hepatocytes have the potential of helping predict clinical outcomes following hepatectomy [82].…”

Section: Cxcr4/cxcl12 Axis and The Crlm Pathwaymentioning

confidence: 99%

See 3 more Smart Citations

Tumour Microenvironment: Overview with an Emphasis on the Colorectal Liver Metastasis Pathway

Giakoustidis

Mudan

Hagemann

2014

Cancer Microenvironment

View full text Add to dashboard Cite

The tumour microenvironment (TME) represents a dynamic network that plays an important role in tumour initiation, proliferation, growth, and metastasis. Cell behaviour may be regulated by interplay of molecular interactions involving positive and negative reinforcement as well as a high level of cross-talk, which determines this system. Additionally, cancer involves cell proliferation, its malignancy defined by the tumour's ability to break down normal tissue architecture and by a dynamic process of invasion and metastasis. The metastatic cascade is regulated by a chain of molecular steps which triggers the progression of the developing cancer cell in the primary tumour into a number of transformations, leading to invasion and proceeding to metastases. Tumour-associated macrophages (TAMs) play a key-role in the progression from inflammatory conditions to cancer; TAMs are also capable of infiltrating the tumour microenvironment. Furthermore, myeloid-derived suppressor cells (MDSCs), a population of inhibitory immune cells, have been reported to increase in various cancer types, although characterising human MDSCs remains difficult, as their phenotype is quite variable. The future of cancer treatment is likely to involve creating more drugs that target these elements as well as others. An overview of the tumour's microenvironment is, therefore, presented in this paper, focusing on the metastatic pathways of primary colorectal cancer to the liver.

show abstract

Section: Cxcr4/cxcl12 Axis and The Crlm Pathwaymentioning

confidence: 99%

Section: Cxcr4/cxcl12 Axis and The Crlm Pathwaymentioning

confidence: 99%

Section: Cxcr4/cxcl12 Axis and The Crlm Pathwaymentioning

confidence: 99%

Section: Cxcr4/cxcl12 Axis and The Crlm Pathwaymentioning

confidence: 99%

See 2 more Smart Citations

Tumour Microenvironment: Overview with an Emphasis on the Colorectal Liver Metastasis Pathway

Giakoustidis

Mudan

Hagemann

2014

Cancer Microenvironment

View full text Add to dashboard Cite

show abstract

“…Furthermore, a recent study found that CXCR4/CXCL12 plays a significant role in pancreatic cancer organ-specific metastasis [46]. However, in renal cancer, the incidence of CXCR4 expression is lower [47,48] than in colorectal [49,50] or pancreatic cancers [51,52], suggesting that this chemokine system may not be the primary driver of the skin-selective homing mechanism.…”

Section: Mechanisms Of Organ Selectivitymentioning

confidence: 99%

Tumor type-specific and skin region-selective metastasis of human cancers: another example of the “seed and soil” hypothesis

Kovács

Hegedűs

Kenessey

et al. 2013

Cancer Metastasis Rev

View full text Add to dashboard Cite

Metastasis of human cancer is an organ-selective process that is determined by anatomical and biological factors as well as by specific microenvironmental properties. Dissemination of visceral malignancies to the skin is rather rare and usually occurs in a later stage of the disease. Using statistical approaches, both positive (renal and lung cancers) and negative (pancreatic and liver cancers) organ preferences can be identified in a variety of cancers. While certain cancer types are characterized by random distribution for skin metastasis (liver cancer), a number of cancers demonstrate a colonization preference to the region of origin: lung cancer to the supradiaphragmatic (mostly chest) and colorectal cancers to the infradiaphragmatic (abdominal) skin regions. In certain cases, however, skin metastasis develops more frequently at specific distant locations, as evidenced by the dissemination of renal cancer at the head and neck region. These findings are clinically relevant and useful especially in patients where skin metastasis is the first indication of a malignancy. Nevertheless, it is a strong argument for the predominant role of microenvironmental factors in cancer dissemination. On the other hand, skin metastases of visceral cancers provide a unique model to analyze the pathomechanisms determining organ selectivity, including the organ-specific vascularization, the dermatome-specific innervation, or immunological and developmental factors.

show abstract

CD164 promotes tumor progression and predicts the poor prognosis of bladder cancer

Zhang

Li³

et al. 2018

Cancer Medicine

View full text Add to dashboard Cite

CD164 was found to play a role in many malignant diseases. But the roles of CD164 in human bladder cancer have not yet been studied. The object of our study was to investigate the functions of CD164 in urothelial bladder carcinoma. The immunohistochemistry (IHC) was performed to evaluate the associations between the expression level of CD164 and clinical‐pathological features of patients, and IHC was used to analyze the relationship between CD164 and CXCR4 in tumor tissues. Real‐time qPCR and Western blot were used to measure the expression of relevant genes. The roles of CD164 in tumor cells and tissues were investigated by in vitro and in vivo experiments. The results of immunohistochemistry found that CD164 was associated with clinical and pathological features of patients. High level of CD164 was related to the distant metastasis and vascular invasion of bladder cancer patients. In vitro, by silencing of CD164, the proliferation, migration, and invasion of tumor cells were inhibited significantly by regulating related proteins such as Ki67, proliferating cell nuclear antigen, matrix metalloproteinases‐2, and matrix metalloproteinases‐9. In vivo, knocking‐down of CD164 could reduce the growth and metastasis of tumors in mice. In addition, a co‐expression was found between CD164 and CXCR4 in tumor tissues. In conclusion, our study demonstrated that CD164 was associated with the poor clinical outcomes of BC patients. Silencing of CD164 could inhibit the progression of tumors in vivo and in vitro, which may become an effective target in the treatment of bladder cancer.

show abstract

CXCR4/CXCL12 expression profile is associated with tumor microenvironment and clinical outcome of liver metastases of colorectal cancer

Cited by 38 publications

References 46 publications

Tumour Microenvironment: Overview with an Emphasis on the Colorectal Liver Metastasis Pathway

Tumour Microenvironment: Overview with an Emphasis on the Colorectal Liver Metastasis Pathway

Tumor type-specific and skin region-selective metastasis of human cancers: another example of the “seed and soil” hypothesis

CD164 promotes tumor progression and predicts the poor prognosis of bladder cancer

Contact Info

Product

Resources

About