2021
DOI: 10.1016/j.cej.2020.126891
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CXCR4 and CD44 dual-targeted Prussian blue nanosystem with daunorubicin loaded for acute myeloid leukemia therapy

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Cited by 24 publications
(11 citation statements)
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“…Particularly, PBNPs can shorten the relaxation time of protons to enable their application as magnetic resonance imaging (MRI) contrast agents. Although PBNPs has promising antioxidative activities in the treatments of RA, its clinical application has been restricted due to the lack of specificity [ 25 , 26 ]. To overcome these defects of conventional drug treatment, it is necessary to develop a novel nanomedicine platform for effective RA therapy.…”
Section: Introductionmentioning
confidence: 99%
“…Particularly, PBNPs can shorten the relaxation time of protons to enable their application as magnetic resonance imaging (MRI) contrast agents. Although PBNPs has promising antioxidative activities in the treatments of RA, its clinical application has been restricted due to the lack of specificity [ 25 , 26 ]. To overcome these defects of conventional drug treatment, it is necessary to develop a novel nanomedicine platform for effective RA therapy.…”
Section: Introductionmentioning
confidence: 99%
“…Chemotherapy is a widely used therapeutic method in clinics. However, chemotherapy is faced with thorny problems such as poor selectivity, toxic side effects on normal tissues, and easy recurrence and metastasis of patients [ 53 ]. Therefore, it is of great significance to explore new therapeutic strategies.…”
Section: Application Of Novel Copper Complexes In Tumor Therapymentioning
confidence: 99%
“…It should be noted that peptides can also be combined with nanozymes to enable the nanozyme with targeting and antagonistic functions. For example, CXCR4 and CD44 dual-targeted Prussian blue nanosystem and Fe 3 O 4 @Pt nanozymes combined with CXCR4 antagonists E5 were developed ( Bai et al, 2021 ; Kong et al, 2021 ). The combination of E5 and nanozymes displayed a superior synergistic therapeutic efficacy against AML in vitro and in vivo , preventing AML cells from homing to bone marrow and migrating to the spleen, lung and liver, which in turn prolonged the survival period of AML mice.…”
Section: Therapeutic Peptide-based Nanoparticles Targeting Signaling ...mentioning
confidence: 99%