CXCR4 and CD44 dual-targeted Prussian blue nanosystem with daunorubicin loaded for acute myeloid leukemia therapy

Bai, Hao; Wang, Tao; Kong, Fei; Zhang, Meichen; Li, Zhuoxuan; Zhuang, Liying; Ma, Ming; Liu, Fangzhou; Wang, Chen; Xu, Haiyan; Gu, Ning

doi:10.1016/j.cej.2020.126891

Cited by 24 publications

(11 citation statements)

References 54 publications

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“…Particularly, PBNPs can shorten the relaxation time of protons to enable their application as magnetic resonance imaging (MRI) contrast agents. Although PBNPs has promising antioxidative activities in the treatments of RA, its clinical application has been restricted due to the lack of specificity [ 25 , 26 ]. To overcome these defects of conventional drug treatment, it is necessary to develop a novel nanomedicine platform for effective RA therapy.…”

Section: Introductionmentioning

confidence: 99%

Nanoenzyme engineered neutrophil-derived exosomes attenuate joint injury in advanced rheumatoid arthritis via regulating inflammatory environment

Zhang

Qin

Sun

et al. 2022

Bioactive Materials

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Section: Introductionmentioning

confidence: 99%

Nanoenzyme engineered neutrophil-derived exosomes attenuate joint injury in advanced rheumatoid arthritis via regulating inflammatory environment

Zhang

Qin

Sun

et al. 2022

Bioactive Materials

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“…Chemotherapy is a widely used therapeutic method in clinics. However, chemotherapy is faced with thorny problems such as poor selectivity, toxic side effects on normal tissues, and easy recurrence and metastasis of patients [ 53 ]. Therefore, it is of great significance to explore new therapeutic strategies.…”

Section: Application Of Novel Copper Complexes In Tumor Therapymentioning

confidence: 99%

Potential of Copper and Copper Compounds for Anticancer Applications

Wang

Chen

et al. 2023

Pharmaceuticals

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Inducing cancer cell death has always been a research hotspot in life sciences. With the continuous deepening and diversification of related research, the potential value of metal elements in inducing cell death has been explored. Taking iron as an example, ferroptosis, mainly characterized by increasing iron load and driving the production of large amounts of lipid peroxides and eventually leading to cell death, has recently attracted great interest in the cancer research community. After iron, copper, a trace element, has received extensive attention in cell death, especially in inducing tumor cell death. Copper and its complexes can induce autophagy or apoptosis in tumor cells through a variety of different mechanisms of action (activation of stress pathways, arrest of cell cycle, inhibition of angiogenesis, cuproptosis, and paraptosis), which are promising in cancer therapy and have become new hotspots in cancer treatment research. This article reviews the main mechanisms and potential applications of novel copper and copper compound-induced cell death, focusing on copper compounds and their anticancer applications.

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“…It should be noted that peptides can also be combined with nanozymes to enable the nanozyme with targeting and antagonistic functions. For example, CXCR4 and CD44 dual-targeted Prussian blue nanosystem and Fe 3 O 4 @Pt nanozymes combined with CXCR4 antagonists E5 were developed ( Bai et al, 2021 ; Kong et al, 2021 ). The combination of E5 and nanozymes displayed a superior synergistic therapeutic efficacy against AML in vitro and in vivo , preventing AML cells from homing to bone marrow and migrating to the spleen, lung and liver, which in turn prolonged the survival period of AML mice.…”

Section: Therapeutic Peptide-based Nanoparticles Targeting Signaling ...mentioning

confidence: 99%

Peptide-assembled nanoparticles targeting tumor cells and tumor microenvironment for cancer therapy

Zhang

2023

Front. Chem.

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Graphical AbstractThe interactions between tumor cells and stromal cells create the tumor microenvironment (TME) which largely affects the cancer progression. The stromal cells can be grouped into three general classes: angiogenic vascular cells, infiltrating immune cells, and tumor fibrosis-related cells. This review introduces the peptide-assembled nanoparticles targeting tumor cells and three types of stromal cells for cancer therapy.

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CXCR4 and CD44 dual-targeted Prussian blue nanosystem with daunorubicin loaded for acute myeloid leukemia therapy

Cited by 24 publications

References 54 publications

Nanoenzyme engineered neutrophil-derived exosomes attenuate joint injury in advanced rheumatoid arthritis via regulating inflammatory environment

Nanoenzyme engineered neutrophil-derived exosomes attenuate joint injury in advanced rheumatoid arthritis via regulating inflammatory environment

Potential of Copper and Copper Compounds for Anticancer Applications

Peptide-assembled nanoparticles targeting tumor cells and tumor microenvironment for cancer therapy

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