CXCR2 Receptor: Regulation of Expression, Signal Transduction, and Involvement in Cancer

Korbecki, Jan; Kupnicka, Patrycja; Chlubek, Mikołaj; Gorący, Jarosław; Gutowska, Izabela; Baranowska-Bosiacka, Irena

doi:10.3390/ijms23042168

Cited by 60 publications

(40 citation statements)

References 171 publications

(274 reference statements)

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“…CXCL1, CXCL2, and CXCL8 are mechanoresponsive proteins that are up-regulated by mechanical stimulation in keratinocytes and fibroblasts [ 88 , 89 , 90 ]. CXCR2, a G-protein-coupled receptor, is a common receptor for CXCL1, CXCL2, and CXCL8, which can promote keratinocyte proliferation and angiogenesis [ 91 , 92 ]. CXCR2 not only activates MAPK-ERK signaling and β1 integrin-FAK, but also is involved in the hypoxia-related HIF-1 signaling pathway [ 92 ].…”

Section: Molecular Mechanismmentioning

confidence: 99%

“…CXCR2, a G-protein-coupled receptor, is a common receptor for CXCL1, CXCL2, and CXCL8, which can promote keratinocyte proliferation and angiogenesis [ 91 , 92 ]. CXCR2 not only activates MAPK-ERK signaling and β1 integrin-FAK, but also is involved in the hypoxia-related HIF-1 signaling pathway [ 92 ]. The binding of CXCR2 to HIF-1 can enhance the tolerance of cells to anoxic environment [ 93 ].…”

Section: Molecular Mechanismmentioning

confidence: 99%

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Mechanical Stretch Induced Skin Regeneration: Molecular and Cellular Mechanism in Skin Soft Tissue Expansion

Guo

Song

Xiong

et al. 2022

IJMS

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Skin soft tissue expansion is one of the most basic and commonly used techniques in plastic surgery to obtain excess skin for a variety of medical uses. However, skin soft tissue expansion is faced with many problems, such as long treatment process, poor skin quality, high retraction rate, and complications. Therefore, a deeper understanding of the mechanisms of skin soft tissue expansion is needed. The key to skin soft tissue expansion lies in the mechanical stretch applied to the skin by an inflatable expander. Mechanical stimulation activates multiple signaling pathways through cellular adhesion molecules and regulates gene expression profiles in cells. Meanwhile, various types of cells contribute to skin expansion, including keratinocytes, dermal fibroblasts, and mesenchymal stem cells, which are also regulated by mechanical stretch. This article reviews the molecular and cellular mechanisms of skin regeneration induced by mechanical stretch during skin soft tissue expansion.

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Section: Molecular Mechanismmentioning

confidence: 99%

Section: Molecular Mechanismmentioning

confidence: 99%

Mechanical Stretch Induced Skin Regeneration: Molecular and Cellular Mechanism in Skin Soft Tissue Expansion

Guo

Song

Xiong

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…CXCR2 is expressed Frontiers in Chemistry frontiersin.org on a variety of cells including neutrophils, keratinocytes, mast cells, eosinophils, macrophages, endothelial cells, and neurons, including sensory neurons. CXCR2 dysregulations are involved in carcinogenesis (Korbecki et al, 2022). The development of a medical system to improve drug-like properties was additionally reported.…”

Section: Us10065934b2mentioning

confidence: 99%

Urea-based anticancer agents. Exploring 100-years of research with an eye to the future

et al. 2022

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Suramin was the first urea-based drug to be approved in clinic, and in the following century a number of milestone drugs based on this scaffold were developed. Indeed, urea soon became a privileged scaffold in medicinal chemistry for its capability to establish a peculiar network of drug−target interactions, for its physicochemical properties that are useful for tuning the druggability of the new chemical entities, and for its structural and synthetic versatility that opened the door to numerous drug design possibilities. In this review, we highlight the relevance of the urea moiety in the medicinal chemistry scenario of anticancer drugs with a special focus on the kinase inhibitors for which this scaffold represented and still represents a pivotal pharmacophoric feature. A general outlook on the approved drugs, recent patents, and current research in this field is herein provided, and the role of the urea moiety in the drug discovery process is discussed form a medicinal chemistry standpoint. We believe that the present review can benefit both academia and pharmaceutical companies’ medicinal chemists to prompt research towards new urea derivatives as anticancer agents.

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“…Then, the Cytoscape Molecular Complex Detection (MCODE) plug-in was used to identify modules in the PPI network. The advanced options were set as node score cutoff = 0.2, degree cutoff = 2, K-core = 2, and max depth = 100 7 . Finally, the Cytoscape plugin Cyto-Hubba was used to select hub genes in the PPI network.…”

Section: Ppi Network Analysis and Determination Of Hub Genesmentioning

confidence: 99%

Identification of the potential cytokines involved in LPS induced acute lung injury in mouse

Qing

Zhou

et al. 2022

Preprint

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To identify the differentially expressed genes encoding promising inflammatory cytokines in murine lungs in the context of acute lung injury (ALI). Through searching the Gene Expression Omnibus (GEO) databases, three GEO datasets were identified based on the LPS induced animal model within 24hr, differentially expressed genes (DEGs) were extracted and analyzed with R studio, the properties of those DEGs were further analyzed by Protein-Protein-Interaction (PPI), Cytoscape, GO and KEGG bioinformatics techniques as well. The potential hub genes in inflammatory related cluster were retrieved and examined furthermore by basal experiments. By searching, GSE1871, GSE104214, and GSE130936 were screened with a priority of animal model formed in less than 24hr. With a criterion of |log2 fold change (FC)| ≥ 2 and an adjusted P-value < 0.01, 923 DEGs were found altogether in three datasets, eventually 87 overlapped genes were achieved commonly. Most of those DEGs come from anchored component of basal membrane and modulate the cytokine-receptors activity, participating in the regulation of responses to cellular stimuli or cytokine-mediated signaling pathways. Through bioinformatics techniques, 2 clusters were separated by K- means algorithm in 87 DEGs, 20 ranked hub genes were finally concluded. The GO and KEEG enrichment analysis of these 20 genes were highly consistent with previous results except that these hub genes are involved in both virus-related and LPS-related biological processes. For LPS induced in vivo experiment, 7 out of 20 genes exhibited mRNA overexpression under cytokine-cytokine receptors interaction pathway, having a more probability to function in inflammation-related cytokine signaling judging from the predicted transcription factor. Altogether, these findings find out some potential DEGs involved in virus and inflammation related biological process, identified 7 potential hub genes could be the therapeutic target on the cytokine-receptor interaction pathway ground in LPS induced ALI.

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CXCR2 Receptor: Regulation of Expression, Signal Transduction, and Involvement in Cancer

Cited by 60 publications

References 171 publications

Mechanical Stretch Induced Skin Regeneration: Molecular and Cellular Mechanism in Skin Soft Tissue Expansion

Mechanical Stretch Induced Skin Regeneration: Molecular and Cellular Mechanism in Skin Soft Tissue Expansion

Urea-based anticancer agents. Exploring 100-years of research with an eye to the future

Identification of the potential cytokines involved in LPS induced acute lung injury in mouse

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