Mechanical Stretch Induced Skin Regeneration: Molecular and Cellular Mechanism in Skin Soft Tissue Expansion

Guo, Yaotao; Song, Yajuan; Xiong, Shaoheng; Wang, Tong; Liu, Wei; Zhang, Yu; Ma, Xianjie

doi:10.3390/ijms23179622

Cited by 12 publications

(15 citation statements)

References 166 publications

(225 reference statements)

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“…In concert with these events, mechanotransduction in keratinocytes has been linked to a variety of membrane receptors, such as integrins, growth factor receptors, G-protein-coupled receptors, ion channels, and cell–cell adhesion molecules such as E-cadherin [ 77 ]. When, for example, β1 integrins are activated, they are shown to mediate rapid downstream ERK1/2 activation as well as YAP activation, ultimately resulting in cell proliferation [ 70 , 71 ].…”

Section: Proliferation Phasementioning

confidence: 99%

Roles of Mechanosensitive Channel Piezo1 in Wound Healing and Scar Formation

Rennekampff,

Tenenhaus,

Rennekampff

et al. 2024

Life

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The ability to heal one’s wounds is perhaps one of the most fundamental and critical of physiologic processes. This coordinated and closely regulated sequential biological process involves a variety of migratory and resident cells. The activation, modulation, balance, and control of these functions depend upon soluble mediators that activate cells and modulate their diverse functions. Recent advances have identified mechanotransduction as functionally integral in many different cell types and physiologic processes. The mechanically sensitive ion channel Pieoz1 is expressed on platelets, neutrophils, macrophages, endothelial cells, keratinocytes, and fibroblasts, all of which are principally involved in wound healing. On a cellular level, there have been great advances in our understanding of the functional role of Piezo1 mechanotransduction in cutaneous wounding. The blocking of Piezo1 has recently been shown to reduce scarring in vivo and yet, thus far, a comprehensive understanding of the roles that Piezo1 plays in in vivo wound healing remains lacking. Recognizing the ever-present and critical importance of optimal and reparative wound healing, and with the availability of new physical mechanomodulating devices, the time is ripe for gaining deeper insights into optimizing wound healing. In this review, we describe the current knowledge of Piezo1 related to wound healing.

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Section: Proliferation Phasementioning

confidence: 99%

Roles of Mechanosensitive Channel Piezo1 in Wound Healing and Scar Formation

Rennekampff,

Tenenhaus,

Rennekampff

et al. 2024

Life

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“…477 During skin natural repair and surgery repair, skin soft tissue expansion encounters many unsolved problems, such as skin quality, tissue retraction rate, and long-term treatment. 478 ECM is abundant in dermis, especially collagens, which provide sufficient TF in the skin. The skin TF on the actin filaments and intermediate filaments integrates integrin-mediated pathways to trigger the maturation of focal adhesion.…”

Section: Mechanotransduction In Embryonic Developmentmentioning

confidence: 99%

Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets

Gao

et al. 2023

Sig Transduct Target Ther

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Cellular mechanotransduction, a critical regulator of numerous biological processes, is the conversion from mechanical signals to biochemical signals regarding cell activities and metabolism. Typical mechanical cues in organisms include hydrostatic pressure, fluid shear stress, tensile force, extracellular matrix stiffness or tissue elasticity, and extracellular fluid viscosity. Mechanotransduction has been expected to trigger multiple biological processes, such as embryonic development, tissue repair and regeneration. However, prolonged excessive mechanical stimulation can result in pathological processes, such as multi-organ fibrosis, tumorigenesis, and cancer immunotherapy resistance. Although the associations between mechanical cues and normal tissue homeostasis or diseases have been identified, the regulatory mechanisms among different mechanical cues are not yet comprehensively illustrated, and no effective therapies are currently available targeting mechanical cue-related signaling. This review systematically summarizes the characteristics and regulatory mechanisms of typical mechanical cues in normal conditions and diseases with the updated evidence. The key effectors responding to mechanical stimulations are listed, such as Piezo channels, integrins, Yes-associated protein (YAP) /transcriptional coactivator with PDZ-binding motif (TAZ), and transient receptor potential vanilloid 4 (TRPV4). We also reviewed the key signaling pathways, therapeutic targets and cutting-edge clinical applications of diseases related to mechanical cues.

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“…The development of organizational engineering technology has provided powerful support for the construction of spinal cord regeneration microenvironments. − Hydrogel microspheres, with their advantages of biocompatibility, controllability, drug delivery capabilities, and support for cell growth, hold great potential for extensive applications in spinal cord injury repair . Gellan gum (GG) is a natural hydrogel that is nontoxic, elastic, and thermally reversible .…”

Section: Introductionmentioning

confidence: 99%

Injectable Near-Infrared Photothermal Responsive Drug-Loaded Multiwalled Carbon Nanotube Hydrogels for Spinal Cord Injury Repair

Sun,

Liu,

Guan

et al. 2023

ACS Appl. Nano Mater.

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Spinal cord injury (SCI) has a high disability rate and poor treatment efficacy and severely affects the health and daily life of patients. Improving the local microenvironment after SCI is crucial for restoring the normal physiological function of the spinal cord. In this study, the injectable near-infrared (NIR) photothermal responsive drug-loaded multiwalled carbon nanotubes (DMWCNTs) containing hydrogel microspheres were prepared by microfluidic technology for SCI treatment. Specifically, paclitaxel (PTX) and vascular endothelial growth factor (VEGF) were loaded into dopamine-modified DMWCNTs, which were then further compounded into gellan gum (GG) by using microfluidic technology to obtain [PTX/VEGF]@DMWCNTs/GG microspheres. The physicochemical properties of the microspheres were characterized using various methods, including transmission electron microscopy (TEM), energy-dispersive X-ray (EDX) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, optical microscopy, and scanning electron microscopy (SEM). Results showed that microspheres with good injectability and controllable drug release were successfully prepared by using microfluidic technology. The presence of MWCNTs endowed the microspheres with photothermal responsiveness, which led to more drug release under NIR irradiation. The cytotoxicity test results showed that the microspheres had no obvious cytotoxicity and the drug-loaded MWCNTs containing hydrogel microspheres could promote the differentiation of neural stem cells (NSCs). Immunofluorescence results in rats with hemisectioned SCI showed that the microspheres promoted the differentiation of NSCs and the growth of neurons and inhibited the formation of astrocytes and glial scars at the lesion site. In conclusion, the injectable near-infrared photothermal responsive drug-loaded multiwalled carbon nanotube hydrogel microspheres prepared in this study exhibit a promoting effect on SCI repair and provide a strategy for developing transplantation materials for SCI treatment.

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Mechanical Stretch Induced Skin Regeneration: Molecular and Cellular Mechanism in Skin Soft Tissue Expansion

Cited by 12 publications

References 166 publications

Roles of Mechanosensitive Channel Piezo1 in Wound Healing and Scar Formation

Roles of Mechanosensitive Channel Piezo1 in Wound Healing and Scar Formation

Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets

Injectable Near-Infrared Photothermal Responsive Drug-Loaded Multiwalled Carbon Nanotube Hydrogels for Spinal Cord Injury Repair

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