Cutting-Edge Regenerative Medicine Technologies for the Treatment of Heart Valve Calcification

Iop, Laura; Gerosa, Gino

doi:10.5772/55327

Cited by 2 publications

(2 citation statements)

References 258 publications

(269 reference statements)

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“…BAV-affected patients have an increased tendency to develop AVS. More than 300,000 valve replacement procedures are performed annually as a unique treatment for end-stage valvular disease ( 24 , 206 ) to restore physiologic blood flow. An AVS echocardiographic sign is a valvular jet velocity reaching 4.7 m/s, and slower values of 2.4 m/s, although altered, indicate sclerosis.…”

Section: Acquired Heart Diseasesmentioning

confidence: 99%

Toward the Effective Bioengineering of a Pathological Tissue for Cardiovascular Disease Modeling: Old Strategies and New Frontiers for Prevention, Diagnosis, and Therapy

Iop

2021

Front. Cardiovasc. Med.

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Cardiovascular diseases (CVDs) still represent the primary cause of mortality worldwide. Preclinical modeling by recapitulating human pathophysiology is fundamental to advance the comprehension of these diseases and propose effective strategies for their prevention, diagnosis, and treatment. In silico, in vivo, and in vitro models have been applied to dissect many cardiovascular pathologies. Computational and bioinformatic simulations allow developing algorithmic disease models considering all known variables and severity degrees of disease. In vivo studies based on small or large animals have a long tradition and largely contribute to the current treatment and management of CVDs. In vitro investigation with two-dimensional cell culture demonstrates its suitability to analyze the behavior of single, diseased cellular types. The introduction of induced pluripotent stem cell technology and the application of bioengineering principles raised the bar toward in vitro three-dimensional modeling by enabling the development of pathological tissue equivalents. This review article intends to describe the advantages and disadvantages of past and present modeling approaches applied to provide insights on some of the most relevant congenital and acquired CVDs, such as rhythm disturbances, bicuspid aortic valve, cardiac infections and autoimmunity, cardiovascular fibrosis, atherosclerosis, and calcific aortic valve stenosis.

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Section: Acquired Heart Diseasesmentioning

confidence: 99%

Toward the Effective Bioengineering of a Pathological Tissue for Cardiovascular Disease Modeling: Old Strategies and New Frontiers for Prevention, Diagnosis, and Therapy

Iop

2021

Front. Cardiovasc. Med.

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“…Interspecies transmission of microorganisms remains an important concern not only for the possible spread of viruses [ 112 , 113 ] but also for potential contaminations by noninactivated resident bacterial species and spores. Available methodologies for terminal sterilization demonstrate effectiveness for all medical devices, apart from the biological class of decellularized tissues.…”

Section: Immune Response Issues In Whole Heart Bioengineeringmentioning

confidence: 99%

The Rapidly Evolving Concept of Whole Heart Engineering

Iop

Sasso

Menabò

et al. 2017

Stem Cells International

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Whole heart engineering represents an incredible journey with as final destination the challenging aim to solve end-stage cardiac failure with a biocompatible and living organ equivalent. Its evolution started in 2008 with rodent organs and is nowadays moving closer to clinical application thanks to scaling-up strategies to human hearts. This review will offer a comprehensive examination on the important stages to be reached for the bioengineering of the whole heart, by describing the approaches of organ decellularization, repopulation, and maturation so far applied and the novel technologies of potential interest. In addition, it will carefully address important demands that still need to be satisfied in order to move to a real clinical translation of the whole bioengineering heart concept.

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Cutting-Edge Regenerative Medicine Technologies for the Treatment of Heart Valve Calcification

Cited by 2 publications

References 258 publications

Toward the Effective Bioengineering of a Pathological Tissue for Cardiovascular Disease Modeling: Old Strategies and New Frontiers for Prevention, Diagnosis, and Therapy

Toward the Effective Bioengineering of a Pathological Tissue for Cardiovascular Disease Modeling: Old Strategies and New Frontiers for Prevention, Diagnosis, and Therapy

The Rapidly Evolving Concept of Whole Heart Engineering

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