The Rapidly Evolving Concept of Whole Heart Engineering

Iop, Laura; Sasso, Eleonora Dal; Menabò, Roberta; Lisa, Fabio Di; Gerosa, Gino

doi:10.1155/2017/8920940

Cited by 22 publications

(28 citation statements)

References 115 publications

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“…2). After decellularization, the cardiac dECM scaffold has shown to provide a complex combination of biochemical and mechanical cues retained from native myocardium tissue that favors the cell attachment, proliferation and cardiovascular differentiation during subsequent recellularization [55, 56]. Recently, heart tissues obtained from multiple species (e.g.…”

Section: Advantages Of Cardiac Decellularized Extracellular Matrixmentioning

confidence: 99%

Cardiac tissue-derived extracellular matrix scaffolds for myocardial repair: advantages and challenges

Hong

Zhang

2019

Regenerative Biomaterials

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Decellularized extracellular matrix (dECM) derived from myocardium has been widely explored as a nature scaffold for cardiac tissue engineering applications. Cardiac dECM offers many unique advantages such as preservation of organ-specific ECM microstructure and composition, demonstration of tissue-mimetic mechanical properties and retention of biochemical cues in favor of subsequent recellularization. However, current processes of dECM decellularization and recellularization still face many challenges including the need for balance between cell removal and extracellular matrix preservation, efficient recellularization of dECM for obtaining homogenous cell distribution, tailoring material properties of dECM for enhancing bioactivity and prevascularization of thick dECM. This review summarizes the recent progresses of using dECM scaffold for cardiac repair and discusses its major advantages and challenges for producing biomimetic cardiac patch.

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Section: Advantages Of Cardiac Decellularized Extracellular Matrixmentioning

confidence: 99%

Cardiac tissue-derived extracellular matrix scaffolds for myocardial repair: advantages and challenges

Hong

Zhang

2019

Regenerative Biomaterials

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“…1 G ) . For example, full heart decellularization and re-cellularization has been investigated to create tissue-engineered organs [ 8 , 172 , 173 ]. In this review, decellularization scaffolds to create engineered cardiac tissue patches will be discussed; however, additional methods and applications are extensively reviewed by Bejleri and Davis [ 174 ].…”

Section: Treatments Based On Loading and Anisotropymentioning

confidence: 99%

Cardiac mechanostructure: Using mechanics and anisotropy as inspiration for developing epicardial therapies in treating myocardial infarction

Dwyer

Coulombe

2021

Bioactive Materials

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The mechanical environment and anisotropic structure of the heart modulate cardiac function at the cellular, tissue and organ levels. During myocardial infarction (MI) and subsequent healing, however, this landscape changes significantly. In order to engineer cardiac biomaterials with the appropriate properties to enhance function after MI, the changes in the myocardium induced by MI must be clearly identified. In this review, we focus on the mechanical and structural properties of the healthy and infarcted myocardium in order to gain insight about the environment in which biomaterial-based cardiac therapies are expected to perform and the functional deficiencies caused by MI that the therapy must address. From this understanding, we discuss epicardial therapies for MI inspired by the mechanics and anisotropy of the heart focusing on passive devices, which feature a biomaterials approach, and active devices, which feature robotic and cellular components. Through this review, a detailed analysis is provided in order to inspire further development and translation of epicardial therapies for MI.

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“…By opportunely combining natural or synthetic scaffolds with specific cell types, tissue engineering aims to recreate in vitro tissue equivalents ( 23 ). The extracellular matrix can be reproduced artificially by an assembly of synthetic polymers or obtained naturally by manipulating human and animal native tissues, for example, by decellularization ( 24 , 25 ). 3-D bioengineered constructs reproducing the tissue or organ of interest find increased utilization to simulate physiologic and pathologic settings in vitro ( 26 – 28 ).…”

Section: In Silico In Vivo and In Vitro mentioning

confidence: 99%

Toward the Effective Bioengineering of a Pathological Tissue for Cardiovascular Disease Modeling: Old Strategies and New Frontiers for Prevention, Diagnosis, and Therapy

Iop

2021

Front. Cardiovasc. Med.

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Cardiovascular diseases (CVDs) still represent the primary cause of mortality worldwide. Preclinical modeling by recapitulating human pathophysiology is fundamental to advance the comprehension of these diseases and propose effective strategies for their prevention, diagnosis, and treatment. In silico, in vivo, and in vitro models have been applied to dissect many cardiovascular pathologies. Computational and bioinformatic simulations allow developing algorithmic disease models considering all known variables and severity degrees of disease. In vivo studies based on small or large animals have a long tradition and largely contribute to the current treatment and management of CVDs. In vitro investigation with two-dimensional cell culture demonstrates its suitability to analyze the behavior of single, diseased cellular types. The introduction of induced pluripotent stem cell technology and the application of bioengineering principles raised the bar toward in vitro three-dimensional modeling by enabling the development of pathological tissue equivalents. This review article intends to describe the advantages and disadvantages of past and present modeling approaches applied to provide insights on some of the most relevant congenital and acquired CVDs, such as rhythm disturbances, bicuspid aortic valve, cardiac infections and autoimmunity, cardiovascular fibrosis, atherosclerosis, and calcific aortic valve stenosis.

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The Rapidly Evolving Concept of Whole Heart Engineering

Cited by 22 publications

References 115 publications

Cardiac tissue-derived extracellular matrix scaffolds for myocardial repair: advantages and challenges

Cardiac tissue-derived extracellular matrix scaffolds for myocardial repair: advantages and challenges

Cardiac mechanostructure: Using mechanics and anisotropy as inspiration for developing epicardial therapies in treating myocardial infarction

Toward the Effective Bioengineering of a Pathological Tissue for Cardiovascular Disease Modeling: Old Strategies and New Frontiers for Prevention, Diagnosis, and Therapy

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