Cutting Edge: Profile of Chemokine Receptor Expression on Human Plasma Cells Accounts for Their Efficient Recruitment to Target Tissues

Nakayama, Takashi; Hieshima, Kunio; Izawa, Dai; Tatsumi, Youichi; Kanamaru, Akihisa; Yoshie, Osamu

doi:10.4049/jimmunol.170.3.1136

Cited by 229 publications

(211 citation statements)

References 18 publications

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“…The axis of CXCR4/CXCL12 plays an important role in metastasis of many tumors (9)(10)(11)(12)(13)(14)(22)(23)(24)(25). Abnormal expression of CXCR4 or CXCL12 has been observed in solid tumors such as ovarian cancer (30), rhabdomysarcoma (26), nasopharyngeal carcinoma (21), melanoma (27), colorectal cancer (28), pancreatic cancer (24), and breast cancer (7).…”

Section: Discussionmentioning

confidence: 99%

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Roles of Chemokine Receptor 4 (CXCR4) and Chemokine Ligand 12 (CXCL12) in Metastasis of Hepatocellular Carcinoma Cells

Liu

Pan

et al. 2008

Cell Mol Immunol

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Chemokines are involved in human hepatocellular carcinoma (HCC) carcinogenesis. However, the exact mechanism of chemokines in HCC carcinogenesis remains unknown. Here we investigated the roles of chemokine receptor 4 (CXCR4) and chemokine ligand 12 (CXCL12) in the metastasis of HCC. We found that the expression levels of CXCR4 mRNA in HCC tissues, MHCC97 cells, and HUVEC cells were 2.52 ± 1.13, 2.34 ± 1.16 and 1.63 ± 1.26, respectively and that the CXCR4 protein levels were 1.38 ± 0.13, 1.96 ± 0.32 and 1.86 ± 0.21, respectively. In contrast, CXCR4 was not detected in normal hepatic tissues. In 78 HCC patients, we also found that the concentration of CXCL12 in cancerous ascitic fluid was 783-8,364 pg/ml and that CXCL12 mRNA level in HCC metastasis portal lymph nodes was 1.21 ± 0.87 but undetectable in normal hepatic tissues. Finally we discovered that recombinant human CXCL12 could induce MHCC97 cells and HUVEC cells to migrate with chemotactic indexes (CI) of 3.9 ± 1.1 and 4.1 ± 1.6, respectively. Cancerous ascitic fluid could also induce the migration of MHCC97 cells with a CI of 1.9 ± 0.8. Thus, our data suggest that CXCR4 and CXCL12 may play an important role in the metastasis of HCC by promoting the migration of tumor cells. Cellular & Molecular Immunology. 2008;5(5):373-378.

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Section: Discussionmentioning

confidence: 99%

“…CXCL12 (stromal cell-derived factor-1, SDF-1) is a member of the CXC chemokine subfamily and binds to CXC chemokine receptor 4 (CXCR4). The expressions of CXCL12 and CXCR4 have been detected in several cancer cells indicating that they may be important in metastasis of tumor cells (10)(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Roles of Chemokine Receptor 4 (CXCR4) and Chemokine Ligand 12 (CXCL12) in Metastasis of Hepatocellular Carcinoma Cells

Liu

Pan

et al. 2008

Cell Mol Immunol

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“…Because EBV-immortalized B cells resemble plasma cells in terms of the continuous production of Igs (24), we hypothesized that CCR10 might be selectively expressed at the terminal differentiation stage of B cells. We have indeed demonstrated that a substantial fraction of plasma cells derived from human bone marrow expresses CCR10 and efficiently migrates to its ligands CCL27 and CCL28 (25). Furthermore, Butcher and his colleagues (26,27) have demonstrated that IgA-ASCs present in various mucosal tissues commonly express CCR10.…”

Section: 25-dihydroxyvitamin D 3 Induces Ccr10 Expression In Terminmentioning

confidence: 91%

1,25-Dihydroxyvitamin D3 Induces CCR10 Expression in Terminally Differentiating Human B Cells

Shirakawa

Nagakubo

Hieshima

et al. 2008

The Journal of Immunology

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In the B cell lineage, CCR10 is known to be selectively expressed by plasma cells, especially those secreting IgA. In this study, we examined the regulation of CCR10 expression in terminally differentiating human B cells. As reported previously, IL-21 efficiently induced the differentiation of activated human CD19+ B cells into IgD−CD38+ plasma cells in vitro. A minor proportion of the resulting CD19+IgD−CD38+ cells expressed CCR10 at low levels. 1,25-Dihydroxyvitamin D3 (1,25-(OH)2D3), the active metabolite of vitamine D3, dramatically increased the proportion of CD19+IgD−CD38+ cells expressing high levels of CCR10. The 1,25-(OH)2D3 also increased the number of CCR10+ cells expressing surface IgA, although the majority of CCR10+ cells remained negative for surface IgA. Thus, 1,25-(OH)2D3 alone may not be sufficient for the induction of IgA expression in terminally differentiating human B cells. To further determine whether 1,25-(OH)2D3 directly induces CCR10 expression in terminally differentiating B cells, we next performed the analysis on the human CCR10 promoter. We identified a proximal Ets-1 site and an upstream potential vitamin D response element to be critical for the inducible expression of CCR10 by 1,25-(OH)2D3. We confirmed the specific binding of Ets-1 and 1,25-(OH)2D3-activated vitamin D receptor to the respective sites. In conclusion, 1,25-(OH)2D3 efficiently induces CCR10 expression in terminally differentiating human B cells in vitro. Furthermore, the human CCR10 promoter is cooperatively activated by Ets-1 and vitamin D receptor in the presence of 1,25-(OH)2D3.

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“…CXCR6, the only known receptor for CXCL16, is also known as Bonzo, TYMSTR, and STRL33, and is a newly characterized chemokine receptor initially described as an HIV coreceptor expressed by a subset of memory/T effector cells, natural killer cells, and plasma cells (26)(27)(28)(29)(30). The present study directly addresses the participation of both CXCR6 and its ligand CXCL16 in leukocyte migration in RA.…”

mentioning

confidence: 85%

“…These chemokines contain a small cytoplasmic domain with a "YXPV" motif that is a potential tyrosine phosphorylation and SH2-binding site, and is preferentially expressed by type 1 lymphocytes. Finally, CXCL16 has a unique receptor-ligand interaction, much like fractalkine (24)(25)(26). These characteristics are important, considering the proinflammatory functions of fractalkine in RA and in rat adjuvant-induced arthritis (AIA) (3,4).…”

mentioning

confidence: 99%

CXCL16‐mediated cell recruitment to rheumatoid arthritis synovial tissue and murine lymph nodes is dependent upon the MAPK pathway

Ruth¹,

Haas²,

Park³

et al. 2006

Arthritis & Rheumatism

107

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Objective. Rheumatoid arthritis (RA) is characterized by profound mononuclear cell (MNC) recruitment into synovial tissue (ST), thought to be due in part to tumor necrosis factor ␣ (TNF␣), a therapeutic target for RA. Although chemokines may also be involved, the mechanisms remain unclear. We undertook this study to examine the participation of CXCL16, a novel chemokine, in recruitment of MNCs to RA ST in vivo and to determine the signal transduction pathways mediating this process. Conclusion. Taken together, these results point to a unique role for CXCL16 as a premier MNC recruiter in RA and suggest additional therapeutic possibilities, targeting CXCL16, its receptor, or its signaling pathways.

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Cutting Edge: Profile of Chemokine Receptor Expression on Human Plasma Cells Accounts for Their Efficient Recruitment to Target Tissues

Cited by 229 publications

References 18 publications

Roles of Chemokine Receptor 4 (CXCR4) and Chemokine Ligand 12 (CXCL12) in Metastasis of Hepatocellular Carcinoma Cells

Roles of Chemokine Receptor 4 (CXCR4) and Chemokine Ligand 12 (CXCL12) in Metastasis of Hepatocellular Carcinoma Cells

1,25-Dihydroxyvitamin D3 Induces CCR10 Expression in Terminally Differentiating Human B Cells

CXCL16‐mediated cell recruitment to rheumatoid arthritis synovial tissue and murine lymph nodes is dependent upon the MAPK pathway

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