CXCL16‐mediated cell recruitment to rheumatoid arthritis synovial tissue and murine lymph nodes is dependent upon the MAPK pathway

Ruth, Jeffrey H.; Haas, Christian; Park, Christy C.; Amin, M. Asif; Martinez, Rita; Haines, G. Kenneth; Shahrara, Shiva; Campbell, Phillip L.; Koch, Alisa E.

doi:10.1002/art.21662

Cited by 98 publications

(114 citation statements)

References 69 publications

(92 reference statements)

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“…These results have shown that the expression of CXCL16, but not that of CX 3 CL1, is associated with colorectal carcinogenesis. Recently, remarkable elevation of soluble CXCL16 in the synovial fluids of rheumatoid arthritis patients was reported (35). It is thus interesting to see whether soluble CXCL16 in serum can also be elevated in CRC patients and is a good biomarker for prognosis.…”

Section: Discussionmentioning

confidence: 99%

High-Level Expression of Chemokine CXCL16 by Tumor Cells Correlates with a Good Prognosis and Increased Tumor-Infiltrating Lymphocytes in Colorectal Cancer

Hojo¹,

Koizumi²,

et al. 2007

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CXCL16 is a new member of the chemokine superfamily, which exists in a transmembrane as well as a soluble form. Its receptor CXCR6 is detected on CD4 + T cells, CD8 + T cells, and natural killer T cells. Here, we report a significant correlation of CXCL16 expression by tumor cells with the infiltration of T cells and prognosis in colorectal cancer (CRC). We first found that CXCL16 expression was consistently up-regulated more in tumor tissues than in normal mucosa derived from the same CRC patients. Four human CRC cell lines also expressed CXCL16 mRNA and secreted soluble CXCL16. We next examined the expression of CXCL16 and infiltration of lymphocytes in CRC specimens (n = 58) by immunohistochemistry. CRC patients with high levels of CXCL16 expression (n = 43) had higher levels of CD4 + and CD8 + tumor-infiltrating lymphocytes (TIL; P < 0.01) than those with low levels of CXCL16 expression (n = 15). Furthermore, the high CXCL16 expression group showed significantly better prognosis than the low CXCL16 expression group (P < 0.05). Collectively, our data suggest that the expression of CXCL16 by tumor cells enhances the recruitment of TILs, thereby bringing about a better prognosis in CRC. Thus, CXCL16 is a new prognostic biomarker and may be useful for the development of a more effective therapeutic strategy for CRC. [Cancer Res 2007;67(10):4725-31]

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Section: Discussionmentioning

confidence: 99%

High-Level Expression of Chemokine CXCL16 by Tumor Cells Correlates with a Good Prognosis and Increased Tumor-Infiltrating Lymphocytes in Colorectal Cancer

Hojo¹,

Koizumi²,

et al. 2007

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“…43 CXCL16 may function to recruit mononuclear cells into affected joints, and elevated levels of CXCL16 have been detected in SF from RA patients. 44 CD209 is a high affinity receptor for ICAM2/3 and may promote cellular adhesion of FLS cells. FCGR2A is a low-affinity Fc receptor (CD32) operating to fix complement, previously implicated in the pathogenesis of RA.…”

Section: Discussionmentioning

confidence: 99%

Distinctive gene expression signatures in rheumatoid arthritis synovial tissue fibroblast cells: correlates with disease activity

et al. 2007

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“…Several chemoattractants stimulate MAPK activities, which in turn are involved in the chemotactic migration of cells (35,36). We also examined the roles of ERK, p38 MAPK, and JNK on WKYMVm-induced NK cell chemotaxis.…”

Section: Wkymvm-induced Nk Cell Chemotaxis Is Mediated By Erkmentioning

confidence: 99%

Functional Expression of Formyl Peptide Receptor Family in Human NK Cells

Kim

et al. 2009

The Journal of Immunology

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We determined the expression of the formyl peptide receptor (FPR) family and the functional roles of the FPR family in NK cells. All tested human NK cells express two members of the FPR family (FPR1 and FPR2). The expression of FPR3 was noted to occur in a donor-specific manner. The stimulation of NK cells with FPR family-selective agonists (fMLF (N-formyl-Met-Leu-Phe), MMK-1, F2L, and WKYMVm (Trp-Lys-Tyr-Met-Val-d-Met)) elicited cytolytic activity in resting NK cells, but not in IL-2-activated NK cells; the cytolytic activity was not inhibited by pertussis toxin. The FPR family agonists also stimulated chemotactic migration of IL-2-activated NK cells, but not resting NK cells; the chemotactic migration was completely inhibited by pertussis toxin. WKYMVm stimulates ERK, p38 MAPK, and JNK activities in both resting and IL-2-activated NK cells. WKYMVm-induced chemotactic migration was partially inhibited by PD98059 (2′-amino-3′-methoxyflavone); however, the inhibition of JNK by its selective inhibitor (SP600125, anthra[1,9-cd]pyrazol-6(2H)-one) dramatically inhibited the WKYMVm-induced cytolytic activity. Furthermore, WKYMVm-induced chemotactic migration and cytolytic activity were partly inhibited by FPR family-selective antagonists (cyclosporin H and WRWWWW). Taken together, our findings indicate that human NK cells express functional members of the FPR family, and in turn the activation of the three members of the FPR receptor family elicit cytolytic activity in NK cells, thus suggesting that the receptors are potentially important therapeutic targets for the modulation of NK cell-mediated immune responses.

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CXCL16‐mediated cell recruitment to rheumatoid arthritis synovial tissue and murine lymph nodes is dependent upon the MAPK pathway

Cited by 98 publications

References 69 publications

High-Level Expression of Chemokine CXCL16 by Tumor Cells Correlates with a Good Prognosis and Increased Tumor-Infiltrating Lymphocytes in Colorectal Cancer

High-Level Expression of Chemokine CXCL16 by Tumor Cells Correlates with a Good Prognosis and Increased Tumor-Infiltrating Lymphocytes in Colorectal Cancer

Distinctive gene expression signatures in rheumatoid arthritis synovial tissue fibroblast cells: correlates with disease activity

Functional Expression of Formyl Peptide Receptor Family in Human NK Cells

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