Cutaneous xanthomatous tumours as an expression of chronic myelomonocytic leukaemia?

Abstract

Nonspecific cutaneous xanthomas have been reported in a variety of lymphocytic neoplastic processes, but to date only three cases of xanthomatous lesions associated with monocytic leukaemias have been described. We now report a patient with a chronic myelomonocytic leukaemia (CMML) associated with these lesions. The clinical and immunohistochemical features do not correspond to any entity previously described and suggest that xanthomas is are a cutaneous expression of the CMML.

Erdheim-Chester disease associated with chronic myelomonocytic leukemia harboring the same clonal mutation

“…Pauline Bonnet, *1 François Chasset, *1 Philippe Moguelet, 2 Noémie Abisror, 3 Raphaël Itzykson, 4 Jean-David Bouaziz, 5 Pierre Hirsch, 6 Annick Barbaud, 1 Julien Haroche, 7 Arsène Mekinian, 3 Zofia Hélias-Rodzewicz, 8 Emmanuelle Clappier, 9 Pierre Fenaux, 4 Olivier Fain, 3 Abdellatif Tazi, 10 Jean-François Emile 8 Information on authorship, contributions, and financial & other disclosures was provided by the authors and is available with the online version of this article at www.haematologica.org.…”

Clinical, Histopathological and Molecular Spectrum of Cutaneous Lesions in Myelodysplastic Syndrome and Myeloproliferative Neoplasms (MDS/MPN): An Integrative Review

“…Furthermore, other case reports and series have published the association of cutaneous xanthomatous tumors [73] and xanthelasma-like lesions fulfilling clinical, histopathological and molecular criteria for ECD associated with CMML, with a proven clonal…”

“…Furthermore, other case reports and series have published the association of cutaneous xanthomatous tumors [73] and xanthelasma-like lesions fulfilling clinical, histopathological and molecular criteria for ECD associated with CMML, with a proven clonal relationship between skin lesions and CMML cells based on molecular analyses using NGS techniques [74], testicular Rosai-Dorfman disease associated with CMML sharing a KRAS variant c 0.35 G>A/p.G12D in both [75] and also Langerhans cell histiocytosis (LCH) associated with MDS and other hematological neoplasms [76,77]. There have been some publications which pointed out that the cell of origin of one third of patients with sys-temic histiocytosis resides in a CD34+ hematopoietic progenitor cell prior to committed monocytes/macrophages [78,79].…”

“…The following supporting information can be downloaded at: https: //www.mdpi.com/article/10.3390/cancers15245888/s1, Table S1: MDS/MPN related dermatoses with indolent clinical course with main clinical, epidemiological, immunophenotypic and genetic features; Table S2: Cutaneous processes related to either MDS/MPN and aggressive clinical behavior with main with main clinical, epidemiological, immunophenotypic and genetic features. References [6,7,12,13,15,16,24,25,29,30,35,[37][38][39][45][46][47][51][52][53][56][57][58][64][65][66][67][68][69][70][71][72][73]75,77,79] are cited in the supplementary materials.…”