A Case of Indeterminate Cutaneous Dendritic Cell Tumors in the Setting of Chronic Myelomonocytic Leukemia

Nyckowski, Timothy; Vance, Paul; Marks, Etan

doi:10.1097/dad.0000000000002195

Cited by 3 publications

(2 citation statements)

References 18 publications

(48 reference statements)

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“…From the first literature search and after deduplication and screening for ICH reports, we gathered 96 papers, describing 142 patients, and spanning from 1985 to 2022. Subsequently, applying the inclusion criteria for the diagnosis of ICH, we excluded 18 papers 14–31 . We then selected and included in the study 78 papers, describing 108 patients (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

“…Subsequently, applying the inclusion criteria for the diagnosis of ICH, we excluded 18 papers. [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] We then selected and included in the study 78 papers, describing 108 patients (Figure 1). 5,8,9,12, From two case series, we included only some of the described patients, as indicated in Table 1.…”

Section: R E Su Ltsmentioning

confidence: 99%

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Indeterminate cell histiocytosis: A systematic review of the literature with a comprehensive revision of clinical, histopathological, and molecular features

Zanella

Berti

Bonometti

2023

Acad Dermatol Venereol

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Indeterminate cell histiocytosis (ICH) is a very rare histiocytic disorder, primarily involving the skin. It affects more frequently adults, often presenting with a generalized papular eruption, and needs to be differentiated from other neoplastic, paraneoplastic, and infectious diseases through clinical and histological examination. The knowledge on ICH is limited to case reports and small series. Thus, the lack of larger multicentric studies has prevented recognizing and addressing the specific clinical need of the entity. In this systematic review, we comprehensively analysed the medical literature describing histologically‐confirmed cases of ICH and divided the patients into epidemiologically and clinically different groups. We demonstrate that ICH in adulthood is strongly associated with the development of haematological (and especially myeloid) neoplasms. In this subset of patients, we identify blastic morphology of neoplastic cells as a novel independent prognostic factor and an early histopathological predictor of an associated myeloid neoplasm. Moreover, we highlight that even though ICH may also present in childhood, these patients often show indolent behaviour. Genetically, ICH emerges as a heterogeneous condition. While patients with associated myeloid neoplasms are enriched in pERK pathway gene mutations, in others a specific ETV3::NCOA2 rearrangement is described. We finally reviewe the nosology of ICH since its first description, its possible cell of origin, and summarize the therapeutic options reported for each different clinical subgroup. With this work, we hope to foster studies on rare cutaneous histiocytosis and their comprehensive multidisciplinary characterization.

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Section: Resultsmentioning

confidence: 99%

Section: R E Su Ltsmentioning

confidence: 99%

Indeterminate cell histiocytosis: A systematic review of the literature with a comprehensive revision of clinical, histopathological, and molecular features

Zanella

Berti

Bonometti

2023

Acad Dermatol Venereol

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Cutaneous Manifestations of Myeloid Neoplasms Exhibit Broad and Divergent Morphologic and Immunophenotypic Features but Share Ancestral Clonal Mutations With Bone Marrow

Sadigh,

DeAngelo,

Garcia

et al. 2024

Modern Pathology

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Indeterminate dendritic cell tumor (IDCT)

Okladnikova,

Merk,

Krivopalov

et al. 2023

Vestnik dermatologii i venerologii

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Indeterminate dendritic cell tumor (IDCT) is rare histiocytic tumor characterized by the proliferation of indeterminate dendritic cells. It is more often diagnosed in middle-aged people, in approximately equal proportions in men and women. The etiology of IDCT is unknown. Differential diagnosis is carried out with other diseases that mimic IDCT and is important for determining treatment tactics. The present paper presents a clinical case of IDCT in a 48-year-old man. Using only the patient's complaints and examination data was not enough to diagnose the disease. The similarity of skin manifestations in IDCT with other skin pathologies requires an immunohistochemical study of the affected areas for CD1a, CD68, S100, Langerin expression evaluation as well as the presence of Birbeck's granules visulization. Routine histological examination does not sufficient for correct IDCT diagnostics.

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A Case of Indeterminate Cutaneous Dendritic Cell Tumors in the Setting of Chronic Myelomonocytic Leukemia

Cited by 3 publications

References 18 publications

Indeterminate cell histiocytosis: A systematic review of the literature with a comprehensive revision of clinical, histopathological, and molecular features

Indeterminate cell histiocytosis: A systematic review of the literature with a comprehensive revision of clinical, histopathological, and molecular features

Cutaneous Manifestations of Myeloid Neoplasms Exhibit Broad and Divergent Morphologic and Immunophenotypic Features but Share Ancestral Clonal Mutations With Bone Marrow

Indeterminate dendritic cell tumor (IDCT)

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