“…A recent review of 26 studies with a total of 443 cases found that, on average, 27.5% of cases had metastases at the time of presentation (127). Almost exclusively, the histopathology of the carcinoma is of the squamous cell type (161), either spinocellular or verrucous (20,252). However, basal cell carcinoma has also been reported (226).…”
Section: Alterations Of Normal Host Responses Chronic Inflammationmentioning
SUMMARY
Although scientific knowledge in viral oncology has exploded in the 20th century, the role of bacteria as mediators of oncogenesis has been less well elucidated. Understanding bacterial carcinogenesis has become increasingly important as a possible means of cancer prevention. This review summarizes clinical, epidemiological, and experimental evidence as well as possible mechanisms of bacterial induction of or protection from malignancy.
“…A recent review of 26 studies with a total of 443 cases found that, on average, 27.5% of cases had metastases at the time of presentation (127). Almost exclusively, the histopathology of the carcinoma is of the squamous cell type (161), either spinocellular or verrucous (20,252). However, basal cell carcinoma has also been reported (226).…”
Section: Alterations Of Normal Host Responses Chronic Inflammationmentioning
SUMMARY
Although scientific knowledge in viral oncology has exploded in the 20th century, the role of bacteria as mediators of oncogenesis has been less well elucidated. Understanding bacterial carcinogenesis has become increasingly important as a possible means of cancer prevention. This review summarizes clinical, epidemiological, and experimental evidence as well as possible mechanisms of bacterial induction of or protection from malignancy.
“…In addition, clinically GVV may mimic many other diseases depending on the localization such as vascular fibroma, even neurotrophic foot ulcer [10,11]. To the best of our knowledge, this is the first reported case about GVV on the leg mimicking eczema.…”
We report a 49-year-old man suffered from giant verrucae vulgaris over shin of his left leg. The lesion had arisen with some maculopapules and misdiagnosed as eczema 4 years previously. After 4 years continuous topical glucocorticoids treatment, the eruption had gradually progressed to a 5 × 5 cm sized plaque covered with some nodules and crusts. Histopathologic examination confirmed the diagnosis of giant verrucae vulgaris. The discontinue therapy with glucocorticoids stopped the development of the lesion, which was totally healed by cryotherapy and topical imiquimod 6 months late. We suggest that topical glucocorticoids continuously for a long-term may contribute to the formation of giant verrucae vulgaris.
“…Cutaneous VC is more common in elderly men. Although the pathogenesis remains unknown, human papilloma virus infection, trauma, ultraviolet radiation exposure, chronic inflammation or use of tobacco, betel nut or alcohol have been associated with the development of VC 1,3–5 …”
Section: Discussionmentioning
confidence: 99%
“…The diagnosis is based on physical examination and the macroscopic and microscopic architectural features. It is essential to obtain a deep biopsy for histological examination 2,5 . Under the microscope, VC presents a papillomatous configuration.…”
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