Cutaneous ulceration in Crohn's disease

Penile Ulcer in Crohn's Disease

“…McCallum & Kinmont (1968 noted skin involvement in 43% of their 138 cases of Crohn's disease, and the subject has been reviewed more recently by Burgdorf (1981). Metastatic cutaneous ulceration may involve moist areas where two skin surfaces are in apposition (Mountain 1970) or dry, exposed skin (Goolamali & Price 1983, Tweedie & McCann 1984. Lesions on the genitalia are rare and were first reported by Parks et al (1965).…”

“…Syphilis, tuberculosis, herpes genitalis, lymphogranuloma venereum, granuloma inguinale, trauma and carcinoma must be excluded. Treatment of cutaneous Crohn's disease is not fully established and has included oral zinc sulphate with concomitant repeated curettage of the ulcer (Mountain 1970), systemic steroids and local treatment with Milton solution, potassium permanganate solution, lotio rubra and various types of steroid creams. The response to local steroid cream by the penile ulcer in the present case was very satisfactory.…”

“…Cutaneous ulceration in Crohn's disease may be perineal, parastomal or metastatic (Mountain 1970). McCallum & Kinmont (1968 noted skin involvement in 43% of their 138 cases of Crohn's disease, and the subject has been reviewed more recently by Burgdorf (1981).…”

Uso de terapia biológica na doença de Crohn metastática: relato de caso e revisão da literatura

“…(17) Em 1970, o termo ulceração metastática foi adotado por Mountain JC para descrever as úlceras cutâneas que surgiam distantes da região perianal ou periostomal. (18) As terapias convencionais têm resultado pouco satisfatório na DCM. (2,15) A terapia biológica com…”

“…(17) Em 1970, o termo ulceração metastática foi adotado por Mountain JC para descrever as úlceras cutâneas que surgiam distantes da região perianal ou periostomal. (18) As terapias convencionais têm resultado pouco satisfatório na DCM. (2,15) No exame proctológico e pelve-perineal sob anestesia, à inspeção, evidenciava-se orifício fistuloso posterior a 2,0 cm da borda anal (Figura 1a), úlcera de 5,0 cm na base do escroto (Figura 1b) e outra úlcera circundando a base do pênis (Figura 1c); ao toque, ânus fibrótico e encarcerado.…”