Cutaneous Tissue Engineering and Lower Extremity Wounds (Part 1)

Boschi, Elena; Longoni, Bianca Maria; Romanelli, Marco; Mosca, Franco

doi:10.1177/1534734604265695

Cited by 6 publications

(3 citation statements)

References 66 publications

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“…Surgical techniques have proven to be effective in stable cases, and melanocyte transfer may be performed by punch minigrafting, split‐thickness skin grafting, hair follicle transplantation, suction blisters, epidermal curettage techniques and cultured and non‐cultured autologous melanocytes. The previous surgical and cultured techniques can be time‐consuming and, in some cases, aesthetically unsatisfying or painful for the patients . In recent years, new non‐cultured autologous epidermal techniques have been developed with similar results to the cultured melanocytes techniques, but are simpler, less expensive and less time‐consuming.…”

Section: Introductionmentioning

confidence: 99%

Epidermal skin grafting in vitiligo: a pilot study

Janowska

Dini

Panduri

et al. 2016

International Wound Journal

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Vitiligo is a multifactorial acquired dermatosis characterised by achromic or hypochromic macules and by the absence of functioning melanocytes. Treatment depends on the extent of the affected areas and on disease activity. Surgical techniques have proven to be effective in stable cases but can be time-consuming and, in some cases, aesthetically unsatisfying or painful for the patients. The aim of the study was to assess the clinical safety and effectiveness of a new automatic epidermal skin harvesting device in patients with stable localised vitiligo over a minimum 12-month period. This new system (CELLUTOME™ Epidermal Harvesting System, KCI, an ACELITY Company, San Antonio, TX) is a commercially available epidermal skin harvesting system that can be used without local anaesthesia or other pre-treatments and has been shown to have low rates of donor site morbidity. Epidermal skin grafts can used in patients with acute and hard to heal chronic wounds, burns and stable vitiligo. The use of advanced therapies may improve the quality of life, have cost benefits and accelerate re-pigmentation of patients with vitiligo. In our preliminary study, this system was seen to be a safe and efficacious means of harvesting epidermal micrografts containing melanocytes for use in patients with stable vitiligo unresponsive to standard therapies.

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Section: Introductionmentioning

confidence: 99%

Epidermal skin grafting in vitiligo: a pilot study

Janowska

Dini

Panduri

et al. 2016

International Wound Journal

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“…Although decellularized allogeneic dermis recapitulates the physical microenvironment of unwounded human skin, these constructs may not be ideal given their expense, limited availability, risk of disease transmission and ethical concerns. The use of biomaterials and sophisticated fabrication techniques to manufacture dermal substitutes has proven successful in basic science studies . Some of these products have been modified for clinical use as temporary biological dressings to promote wound healing .…”

Section: Future Perspectivesmentioning

confidence: 99%

Tissue engineering for the management of chronic wounds: current concepts and future perspectives

Wong

Gurtner

2012

Experimental Dermatology

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Chronic wounds constitute a significant and growing biomedical burden. With the increasing growth of populations prone to dysfunctional wound healing, there is an urgent and unmet need for novel strategies to both prevent and treat these complications. Tissue engineering offers the potential to create functional skin, and the synergistic efforts of biomedical engineers, material scientists, and molecular and cell biologists have yielded promising therapies for non-healing wounds. However, traditional paradigms for wound healing focus largely on the role of inflammatory cells and fail to incorporate more recent research highlighting the importance of stem cells and matrix dynamics in skin repair. Approaches to chronic wound healing centred on inflammation alone are inadequate to guide the development of regenerative medicine-based technologies. As the molecular pathways and biologic defects underlying non-healing wounds are further elucidated, multifaceted bioengineering systems must advance in parallel to exploit this knowledge. In this viewpoint essay, we highlight the current concepts in tissue engineering for chronic wounds and speculate on areas for future research in this increasingly interdisciplinary field.

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“…This approach is based on the use of biomaterials such as engineered cells, tissues, and synthetic scaffolds to maintain, replace, or repair organ function with correction of the underlying disease. 2 Therapeutic approaches for tissue-engineered products are currently based on 3 strategies: the use of cells without matrix (such as autologous cell transplant or stem cell therapy), synthetic polymers with or without growth factors and cytokines, and a 3-dimensional matrix with cells within. 3…”

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confidence: 99%

Cutaneous Tissue Engineering and Lower Extremity Wounds (Part 2)

Dini

Romanelli

Piaggesi

et al. 2006

The International Journal of Lower Extremity Wounds

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In a previous article, this group described the principles involved in the development of bioengineered skin equivalents that held out much promise. This article has examined some of the uses of such products in treating venous ulcers, diabetic foot ulcers, and skin diseases leaving skin wounds. Data encouraging the use of such products in certain indications are available. The costs of using such products are also appreciated.

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Cutaneous Tissue Engineering and Lower Extremity Wounds (Part 1)

Cited by 6 publications

References 66 publications

Epidermal skin grafting in vitiligo: a pilot study

Epidermal skin grafting in vitiligo: a pilot study

Tissue engineering for the management of chronic wounds: current concepts and future perspectives

Cutaneous Tissue Engineering and Lower Extremity Wounds (Part 2)

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