Epidermal skin grafting in vitiligo: a pilot study

Janowska, Agata; Dini, Valentina; Panduri, Salvatore; Macchia, Michela; Oranges, Teresa; Romanelli, Marco

doi:10.1111/iwj.12632

Cited by 14 publications

(13 citation statements)

References 23 publications

(35 reference statements)

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“…Furthermore, SBEG may lead to post-inflammatory hyperpigmentation in the donor site, and placement of the graft is sometimes difficult [10][11][12][13]. Pixel array epidermal grafting with an automatic harvesting system (Cellutome ® ) has been reported to be a simple, time saving, and effective office-based method for stable vitiligo [14]. With this method, the placement of grafts is straightforward, and there is no difficulty distinguishing the epidermal side from the dermal side.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Outcome Assessment of Color Match and the Extent of Repigmentation after Pixel Array Epidermal Grafting for Head and Neck Stable Vitiligo: A Prospective Cohort Study

et al. 2020

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Background: Epidermal grafting with an automatic harvesting system has been reported as a simple and efficacious procedure for stable vitiligo. However, no prospective cohort study has quantitatively evaluated the color matching and extent of repigmentation in the head and neck area by this method. Objective: To evaluate the color matching and extent of repigmentation after pixel array epidermal grafting by image analysis software and physicians’ naked eye. Methods: Ten Asian patients with head and neck vitiligo lesions stable for at least 6 months were treated with pixel array epidermal grafting with an automatic harvesting system and post-grafting phototherapy. The patients were evaluated 1, 3, and 6 months post grafting for the percentage of repigmentation by blinded physicians’ assessment and image analysis software. The color matching index of repigmentation was evaluated by measuring the melanin index in the grafted area and the juxta non-vitiliginous area. Results: The average blister harvest time was 46.3 ± 9.7 min. The area percentile of repigmentation by the image analysis software were 32.3 ± 26.8, 64.6 ± 29.4, and 76.5 ± 25.9 at 1, 3, and 6 months post grafting, respectively. There were no significant differences between the physicians’ assessments and the results from the image analysis software. The change in the area percentile of repigmentation between 3 and 6 months post grafting was only statistically significant using image analysis software. The grafted area achieved a color match of 83.1 ± 13.4% that of the juxta non-vitiliginous area 6 months after grafting. Three patients had repigmentation of leukotrichia. Conclusion: By quantitative measurement, uniform pixel array micrografts provide a very good extent of repigmentation and color match in the head and neck area. Image analysis software revealed a steady increase in repigmentation after POM3 until POM6, which was not detected by subjective assessment.

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Section: Introductionmentioning

confidence: 99%

Quantitative Outcome Assessment of Color Match and the Extent of Repigmentation after Pixel Array Epidermal Grafting for Head and Neck Stable Vitiligo: A Prospective Cohort Study

et al. 2020

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“…Janowska et al observed the re-pigmentation after use of the Cellutome™ only by a digital camera (2). Wood's lamp may help to detect early re-pigmentation not only in the forms of pigmented islands but also in those of hypochromic islands, which is hypothesised as the first early sign of re-pigmentation.…”

Section: Discussionmentioning

confidence: 99%

“…We use Cellutome™, which applies negative pressure and heat, to harvest the epidermal micrografts. This system saves time, reduces pain and leaves no hyperpigmentation on donor sites . However, the prerequisite for success is still the stable status of the disease.…”

Section: Discussionmentioning

confidence: 99%

Wood's lamp for vitiligo disease stability and early recognition of initiative pigmentation after epidermal grafting

Wang

Chang

Cheng

2017

International Wound Journal

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The prerequisite for a successful vitiligo epidermal grafting surgery is the stable status of the disease. We used Wood's lamp to assess vitiligo activity to determine the disease stability, surgical grafting timing and the early recognition of re-pigmentation after grafting. Amelanotic lesions with sharply demarcated borders are typically stable and are good candidates for grafting. The re-pigmentation was first recognised under Wood's lamp as hypochromic islands, which progressed to normally pigmented islands. For patients more prone to relapse, follow up with Wood's lamp also provides more accurate surveillance.

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“…

Dear Editors, The recent study published in the journal entitled 'Epidermal skin grafting in vitiligo: a pilot study' by Janowska et al (1) illustrated that using epidermal skin grafting is effective and safe for stable vitiligo unresponsive to standard therapies. In this study, additional NB-UVB therapies were given to four patients with minimal repigmentation after the surgery.The European guidelines suggest that a combination of UV-light treatment and surgical interventions could provide the best outcome and long-term stability (2).

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mentioning

confidence: 99%

“…The recent study published in the journal entitled ‘Epidermal skin grafting in vitiligo: a pilot study’ by Janowska et al . illustrated that using epidermal skin grafting is effective and safe for stable vitiligo unresponsive to standard therapies. In this study, additional NB‐UVB therapies were given to four patients with minimal repigmentation after the surgery.…”

mentioning

confidence: 99%