Keratoacanthoma (KA) is classically a benign skin neoplasm that occurs on damaged photo. But the relationship between squam cell carcinome and keratoacanthoma is still on. To date, no clinical or histological criteria can confirm the diagnosis. The very different biologic tendency of rapid onset and spontaneous regression seen in typical KAs has led many clinicians and dermatopathologists to view this lesion as a noninvasive benign entity distinct from SCC. Many authors suggest that there is no single histopathological diagnostic criterion to differentiate KA from traditional SCC. We report A cases of a patients with a Keratoacanthoma that behaved as an invasive SCC.