Cutaneous squamous cell carcinoma

Que, Syril Keena T.; Zwald, Fiona O.; Schmults, Chrysalyne D.

doi:10.1016/j.jaad.2017.08.058

Cited by 121 publications

(80 citation statements)

References 79 publications

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“…Invasive SCC usually is elevated and, depending on differentiation, hyperkeratotic or ulcerated. Keratoacanthoma can be regarded as a highly differentiated variant of SCC [ 45 , 58 ] although some authors regard it as a benign neoplasm [ 59 ].…”

Section: Dermatoscopy Of Non-melanoma Skin Cancer (Keratinocyte Cancementioning

confidence: 99%

Dermatoscopy of Neoplastic Skin Lesions: Recent Advances, Updates, and Revisions

Weber

Tschandl

Sinz

et al. 2018

Curr. Treat. Options in Oncol.

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Opinion statementDermatoscopy (dermoscopy) improves the diagnosis of benign and malignant cutaneous neoplasms in comparison with examination with the unaided eye and should be used routinely for all pigmented and non-pigmented cutaneous neoplasms. It is especially useful for the early stage of melanoma when melanoma-specific criteria are invisible to the unaided eye. Preselection by the unaided eye is therefore not recommended. The increased availability of polarized dermatoscopes, and the extended use of dermatoscopy in non-pigmented lesions led to the discovery of new criteria, and we recommend that lesions should be examined with polarized and non-polarized dermatoscopy. The “chaos and clues algorithm” is a good starting point for beginners because it is easy to use, accurate, and it works for all types of pigmented lesions not only for those melanocytic. Physicians, who use dermatoscopy routinely, should be aware of new clues for acral melanomas, nail matrix melanomas, melanoma in situ, and nodular melanoma. Dermatoscopy should also be used to distinguish between different subtypes of basal cell carcinoma and to discriminate highly from poorly differentiated squamous cell carcinomas to optimize therapy and management of non-melanoma skin cancer. One of the most exciting areas of research is the use of dermatoscopic images for machine learning and automated diagnosis. Convolutional neural networks trained with dermatoscopic images are able to diagnose pigmented lesions with the same accuracy as human experts. We humans should not be afraid of this new and exciting development because it will most likely lead to a peaceful and fruitful coexistence of human experts and decision support systems.

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Section: Dermatoscopy Of Non-melanoma Skin Cancer (Keratinocyte Cancementioning

confidence: 99%

Dermatoscopy of Neoplastic Skin Lesions: Recent Advances, Updates, and Revisions

Weber

Tschandl

Sinz

et al. 2018

Curr. Treat. Options in Oncol.

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“…In general, patients with BCCs or resectable primary cSCCs have a good prognosis, whereas metastatic cSCC is associated with poor outcome [26]. Radiation and chemotherapy can be used for advanced and recurrent high-risk tumors that cannot be excised, especially those located in the facial area [36]. Recently, targeted therapies have been approved for therapy of advanced BCC and cSCC.…”

Section: Keratinocyte Carcinomasmentioning

confidence: 99%

Long non-coding RNAs in cutaneous biology and keratinocyte carcinomas

Piipponen

Nissinen

Kähäri

2020

Cell. Mol. Life Sci.

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Long non-coding RNAs (lncRNAs) are a largely uncharacterized group of non-coding RNAs with diverse regulatory roles in various biological processes. Recent observations have elucidated the functional roles of lncRNAs in cutaneous biology, e.g. in proliferation and differentiation of epidermal keratinocytes and in cutaneous wound repair. Furthermore, the role of lncRNAs in keratinocyte-derived skin cancers is emerging, especially in cutaneous squamous cell carcinoma (cSCC), which presents a significant burden to health care services worldwide and causes high mortality as metastatic disease. Elucidation of the functions of keratinocyte-specific lncRNAs will improve understanding of the molecular pathogenesis of epidermal disorders and skin cancers and can be exploited in development of new diagnostic and therapeutic applications for keratinocyte carcinomas. In this review, we summarize the current evidence of functionally important lncRNAs in cutaneous biology and in keratinocyte carcinomas.

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“…It arises in cells of stratified epithelia such as the epidermis, esophagus and mucosal linings of the upper airways, lips, mouth, salivary glands, throat and larynx (head and neck SCC, HNSCC). Cutaneous SCC is the second most common non-melanoma skin cancer—and although most of them are easily eradicated by surgical excision, a subset of these tumors become highly aggressive and show higher recurrence and metastatic rates, causing the death of patients [ 1 ]. On the other hand, HNSCCs had an incidence of more than 700,000 cases worldwide in 2018, with 42–56% mortality [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Smoking and excessive alcohol intake predispose to development of HNSCC. Currently, an increasing proportion of these tumors has arisen as a consequence of infection with human papilloma viruses [ 1 , 3 ]. Despite recent advances in the knowledge of the molecular landscape of SCCs [ 3 ], the factors contributing to the malignant behavior and clinical aggressiveness of many SCCs—particularly HNSCCs—remain poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Interplay between Podoplanin, CD44s and CD44v in Squamous Carcinoma Cells

Renart

Ramírez

Ramos

et al. 2020

Cells

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Podoplanin and CD44 are transmembrane glycoproteins involved in inflammation and cancer. In this paper, we report that podoplanin is coordinately expressed with the CD44 standard (CD44s) and variant (CD44v) isoforms in vivo—in hyperplastic skin after a pro-inflammatory stimulus with 12-O-tetradecanoylphorbol-13-acetate (TPA)—and in vitro—in cell lines representative of different stages of mouse-skin chemical carcinogenesis, as well as in human squamous carcinoma cell (SCC) lines. Moreover, we identify CD44v10 in the mouse-skin carcinogenesis model as the only CD44 variant isoform expressed in highly aggressive spindle carcinoma cell lines together with CD44s and podoplanin. We also characterized CD44v3-10, CD44v6-10 and CD44v8-10 as the major variant isoforms co-expressed with CD44s and podoplanin in human SCC cell lines. Immunofluorescence confocal microscopy experiments show that these CD44v isoforms colocalize with podoplanin at plasma membrane protrusions and cell–cell contacts of SCC cells, as previously reported for CD44s. Furthermore, CD44v isoforms colocalize with podoplanin in chemically induced mouse-skin SCCs in vivo. Co-immunoprecipitation experiments indicate that podoplanin physically binds to CD44v3-10, CD44v6-10 and CD44v8-10 isoforms, as well as to CD44s. Podoplanin–CD44 interaction is mediated by the transmembrane and cytosolic regions and is negatively modulated by glycosylation of the extracellular domain. These results point to a functional interplay of podoplanin with both CD44v and CD44s isoforms in SCCs and give insight into the regulation of the podoplanin–CD44 association.

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Cutaneous squamous cell carcinoma

Cited by 121 publications

References 79 publications

Dermatoscopy of Neoplastic Skin Lesions: Recent Advances, Updates, and Revisions

Dermatoscopy of Neoplastic Skin Lesions: Recent Advances, Updates, and Revisions

Long non-coding RNAs in cutaneous biology and keratinocyte carcinomas

Interplay between Podoplanin, CD44s and CD44v in Squamous Carcinoma Cells

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