Cutaneous pseudolymphoma in association with Leishmania donovani

Flaig, Michael J.; Rupec, Rudolf A.

doi:10.1111/j.1365-2133.2007.08129.x

Cited by 23 publications

(11 citation statements)

References 12 publications

(17 reference statements)

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“…The etiology of cutaneous lymphoid hyperplasia is diverse. It is usually idiopathic, but may also occur as a reactive process associated with infections such as herpes zoster (2), Borrelia burgdorferi (3), Leishmania donovani (4), molluscum contagiosum (5), use of some drugs (6), or following exposure to a contact allergen (7). Introduction of a foreign antigen into the skin by means of arthropod bites (8); vaccination (9); prick testing; specific immune therapy (10); silicon implant; body piercing; acupuncture (11); and tattoo (12) can also incite this response.…”

Section: Discussionmentioning

confidence: 99%

Childhood Cutaneous Lymphoid Hyperplasia Following Feline Scratches

Madhogaria

Carr

Gach

2010

Pediatric Dermatology

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Cutaneous lymphoid hyperplasia or pseudolymphoma is a usually benign inflammatory response that mimics lymphoma. Stimulation from foreign antigens introduced into the skin can induce this response. Scratches from pets are an effective mode of transmitting infections and inoculating foreign antigens into the skin. We report an unusual case of a child where cutaneous lymphoid hyperplasia presented as subcutaneous nodules at sites scratched by a pet cat.

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Section: Discussionmentioning

confidence: 99%

Childhood Cutaneous Lymphoid Hyperplasia Following Feline Scratches

Madhogaria

Carr

Gach

2010

Pediatric Dermatology

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“…CL has best been characterized in humans. It encompasses a heterogeneous group of lymphocytic proliferations considered by most investigators to be a reaction pattern that reflects a localized immunological response to a range of stimuli including drugs, arthropod‐bites, contactants or infectious diseases such as borreliosis, leishmaniosis or Molluscum contagiosum 1,2,8,10,25 . However, because a direct association with antigen stimulation cannot be substantiated in many cases, the lesions are often referred to as idiopathic CL.…”

Section: Discussionmentioning

confidence: 99%

“…Cutaneous lymphocytosis (CL), cutaneous pseudolymphoma, cutaneous lymphoid hyperplasia, lymphocytoma cutis and lymphoid dyscrasia are terms used to refer to a heterogeneous group of lymphoid proliferations in the skin of humans 1–10 . Typically, CL is considered the result of a persistent antigenic stimulation of either T or B cells.…”

Section: Introductionmentioning

confidence: 99%

Indolent cutaneous T‐cell lymphoma presenting as cutaneous lymphocytosis in dogs

Affolter

Gross²,

Moore

2009

Veterinary Dermatology

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Cutaneous lymphoproliferative diseases encompass a spectrum of lesions, ranging from self-limiting, reactive infiltrates to high-grade lymphomas. In humans, cutaneous lymphocytosis (CL) refers to self-limiting or slowly progressive monomorphic lymphocytic infiltrates of mostly unknown cause. It morphologically mimics cutaneous lymphoma. CL in cats also is a slowly progressive disease. Immunophenotyping and clonality testing of feline CL support an indolent lymphoma for the majority of cases studied. This study reports CL in dogs. Erythematous, scaly and alopecic macules, patches or plaques were present in eight dogs. Breed predilection was not observed; six of eight dogs were females; and ages ranged from 5 to 14 years. Diffuse monomorphic non-epitheliotropic infiltrates of CD3(+) (eight of eight), CD45(-) (four of eight) or CD45(+/-) (four of eight) and CD45RA(-) (seven of eight) T lymphocytes were present in the superficial and mid-dermis. Further immunophenotyping of five cases revealed TCR-gammadelta(+) T cells (one of five) or TCR-alphabeta(+) (four of five) T cells. TCR-alphabeta(+) populations were either CD8(+) (two of four) or CD4(-)CD8(-) (2/4). Clonality testing found clonal (seven of eight) or pseudoclonal (one of eight) rearrangement of the TCR-gamma locus of the lesional T cells. Prednisone, prednisolone and methylprednisolone acetate were the most commonly administered drugs. The lesions remained stable for long periods up to 6 years. Five dogs were euthanized due to progression of the skin lesions (three of five), peripheral lymphadenopathy of unknown origin (one of five) or high-grade lymphoma (one of five). One dog was lost for follow-up and two dogs are still alive (17 and 9 months after diagnosis). Canine CL is best considered an initially indolent lymphoma, with slow progression and a potential for progression to high-grade lymphoma.

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“…Depending on whether such infiltrates imitate B‐cell or T‐cell lymphomas of the skin they may assume different patterns ranging from lichenoid to dense perivascular, nodular and diffuse patterns 1–4 . Of some pseudolymphomatous infiltrates, the cause is known or can be identified by additional investigations, namely, lymphadenosis benigna cutis of borreliosis, 5–7 and some manifestations of infections by herpesviruses 8,9 or Leishmania 10 which all can be proven by specific polymerase chain reaction (PCR) for Borrelia ‐specific, herpesvirus‐specific and Leishmania ‐specific DNA, respectively. For other infiltrates, the cause is not unequivocal and arthropod bites as well as drugs have been suggested as the possible origin 1–4,11–20 .…”

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confidence: 99%

Pseudoclonality in cutaneous pseudolymphomas: a pitfall in interpretation of rearrangement studies

Böer¹,

Tirumalae

Bresch

et al. 2008

British Journal of Dermatology

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B-cell and T-cell pseudoclones are not uncommonly encountered in moderately dense pseudolymphomatous infiltrates (23% and 13%, respectively). B-cell clonality is seen occasionally in pseudolymphomatous infiltrates (13%), especially when they are sparse in B lymphocytes. Therefore, rearrangement studies cannot be interpreted without correlation with morphological patterns and immunophenotyping of infiltrates and they need to be confirmed by duplicate or triplicate tests in order to prevent overinterpretation.

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Cutaneous pseudolymphoma in association with Leishmania donovani

Cited by 23 publications

References 12 publications

Childhood Cutaneous Lymphoid Hyperplasia Following Feline Scratches

Childhood Cutaneous Lymphoid Hyperplasia Following Feline Scratches

Indolent cutaneous T‐cell lymphoma presenting as cutaneous lymphocytosis in dogs

Pseudoclonality in cutaneous pseudolymphomas: a pitfall in interpretation of rearrangement studies

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