Cutaneous Neuroendocrine (Merkel Cell) Carcinoma

Smith, Damon E.; Bielamowicz, Steven; Kagan, Anna; Anderson, Paul; Peddada, Anuj V.

doi:10.1097/00000421-199506000-00004

Cited by 85 publications

(58 citation statements)

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“…2,10,12,13 In addition, some have recommended a prophylactic lymphadenectomy due to the propensity for early occult spread to regional nodes. 14,15 More recently, sentinel lymph-node mapping has been used in MCC to detect the presence of regional nodal metastases. This technique allows one to perform selective lymph-node dissection.…”

Section: Discussionmentioning

confidence: 99%

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Multimodality Management of Merkel Cell Carcinoma

Ott

Tanabe²,

Gadd³

et al. 1999

Arch Surg

180

164

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Section: Discussionmentioning

confidence: 99%

“…14,15 These authors demonstrate improved locoregional control but no impact on survival. No comment is made about complications of the lymphnode dissection (edema, infection, and pain), so it is not clear at what cost this local benefit was obtained.…”

mentioning

confidence: 96%

Multimodality Management of Merkel Cell Carcinoma

Ott

Tanabe²,

Gadd³

et al. 1999

Arch Surg

180

164

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“…[5][6][7] In 1 study of 35 patients with Merkel cell carcinoma who presented with Stage I and Stage II disease, there was an overall recurrence rate of 50% . 6 Regional lymph node recurrence comprised 47% of the total failure rate and the median time to this recurrence was 5 months. In addition, this study described lymph node recurrence even within previously dissected lymph node basins.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical analysis of sentinel lymph nodes from patients with Merkel cell carcinoma

Allen

Busam

Hill

et al. 2001

Cancer

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Mechanical displacement of the ring by around 40 % along the approximately 9‐nm long dumbbell‐shaped component has been seen in a bistable redox‐controllable [2]rotaxane. Chemical oxidation of the tetrathiafulvalene recognition station (green, see scheme) in the dumbbell‐shaped component, which also contains a 1,5‐dioxynaphthalene recognition station (red), results in the cyclobis(paraquat‐p‐phenylene) tetracation (blue) undergoing translation from the much preferred green station to the second‐choice, red station.

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“…Historic data typically derived from small case series have reported dismal 5-year survival rates ranging from 29% to 64%. 7,9,10,19,[21][22][23] However, studies involving larger number of patients have suggested up to 74% survival rates at 5 years. 15,24,25 The most important prognostic determinant is tumor stage, 3,9,10,[24][25][26] which is most accurate if information of the pathologically confirmed status of the regional lymph nodes is included (pathologic stage).…”

mentioning

confidence: 99%

Merkel cell carcinoma

Andea

Coit

Amin

et al. 2008

Cancer

194

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BACKGROUND. Currently, little is known regarding the potential prognostic value of histologic features in primary cutaneous neuroendocrine (Merkel cell) carcinomas (MCC). METHODS. In a retrospective review of the tumor histology and clinical outcome data (median follow‐up, 51 months; range, 3‐224 months) of 156 patients with a diagnosis of MCC, the following histologic features were evaluated: tumor thickness, tumor size (greatest dimension of the tumor), microanatomic compartment involved by tumor (dermis and/or subcutis and/or deeper), tumor growth pattern (nodular circumscribed vs infiltrative), lymphovascular invasion (LVI), tumor‐infiltrating lymphocytes, tumor necrosis, ulceration, and solar elastosis. RESULTS. The overall 5‐year survival rate was 67.5%. On univariate analysis, parameters that were associated significantly with survival were tumor thickness (P = .001), tumor size (P = .0002), deepest anatomic compartment involved by tumor (P = .0003), tumor growth pattern (P = .003), LVI (P < .00001), tumor‐infiltrating lymphocytes (P = .05), and solar elastosis (P = .04). On multivariate analysis, the presence of a nodular growth pattern, low tumor depth, and absence of LVI were associated with longer survival. CONCLUSIONS. In addition to the known prognostic value of tumor stage, 3 histologic features were identified to have prognostic significance: tumor thickness (depth of tumor invasion), the presence of LVI, and tumor growth pattern. Cancer 2008. © 2008 American Cancer Society.

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Cutaneous Neuroendocrine (Merkel Cell) Carcinoma

Cited by 85 publications

References 0 publications

Multimodality Management of Merkel Cell Carcinoma

Multimodality Management of Merkel Cell Carcinoma

Immunohistochemical analysis of sentinel lymph nodes from patients with Merkel cell carcinoma

Merkel cell carcinoma

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