Cutaneous Neoplasms in Dogs Associated with Canine Oral Papillomavirus Vaccine

Bregman, Carla L.; Hirth, R. S.; Sundberg, John P.; Christensen, Eidi

doi:10.1177/030098588702400602

Cited by 71 publications

(51 citation statements)

References 13 publications

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“…Alternatively, the hyperkeratosis could be induced by factors released by the neighboring neo-Vet Patho1 30: 3,1993 plasm or be promoted by exposure to environmental carcinogens. The bacteria seen in both the keratin and cell debris of nodular and ulcerative lesions may play a role in the enlargement of these lesions and may stimulate some of the extensive surrounding inflammatory response.…”

Section: Discussionmentioning

confidence: 99%

Avian Keratoacanthoma (Dermal Squamous Cell Carcinoma) in Broiler Chicken Carcasses

Hafner

Harmon

Stewart³

et al. 1993

Vet Pathol

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trated on the morphologic appearance of the larger ulcerative lesions. In one study, examination of 419 lesions in an unspecified number ofcarcasses indicated no predilection for specific feather tracts; only 17 of these lesions appeared to be in wing tracts. 13 The present study was performed to characterize the location and appearance of nodular and ulcerative lesions in a large number ofcarcasses. Lesions were also examined histologically, and the histologic appearance of small nodular lesions was characterized. Through a retrospective study, the prevalence of multiple lesions at slaughter was examined in relation to individual flock production parameters and specific disease condemnations to identify associated environmental factors or diseases. Vet Pathol 30:265-270 (1993) Abstract. Multiple lesions of dermal squamous cell carcinoma are found at a low frequency (0.04%) in the carcasses of young meat-type chickens at slaughter. For this study, affected carcasses (n = 308) were removed from the processing line, and lesions were characterized by size, distribution, and morphology. Carcasses were also sexed and examined for evidence of metastasis. Nodular (n = 297) and ulcerative (n = 1,707) lesions were counted and examined. Most lesions were present in the pectoral, dorsopelvic, and femoral feather tracts. Few lesions (n = 11) were found in wing tracts. Mean diameter was 5.4 mm for ulcerative lesions and 3.1 mm for nodular lesions. Histologic sections of ulcerative (n = 579) and nodular (n = 113) lesions were examined. Small nodular lesions originated from hyperplastic feather follicle epithelium. Nodules contained keratin-filled cysts lined by squamous epithelium that were associated with isolated islands and infiltrating cords of dermal keratinocytes. Loss of surface epithelium resulted in noduloulcerative and ulcerative lesions. Invasion of underlying skeletal muscle and evidence of visceral metastasis were not present, but invasion through elastic laminae and into the subcutis was present in 20.5% (134/654) of the lesions examined. The nodular lesions in these carcasses were morphologically similar to early nodular lesions previously described in live chickens as avian keratoacanthomas. A retrospective study compared selected production parameters and disease condemnations to the prevalence of squamous cell carcinoma in 665 flocks of broiler chickens. There was a positive correlation (P < 0.000 I) with the occurrence of airsacculitis but a negative correlation with increased age and condemnations for leukosis (P < 0.000 I). Tumor frequency followed a pronounced seasonal pattern, with decreased prevalence in summer months.Key words: Avian; broilers; chickens; keratoacanthoma; skin neoplasms; squamous cell carcinoma.Neoplasms of epithelial origin are rare among avian species.t' Lesions discovered at slaughter in the skin of broiler carcasses have been described as ulcerative,2,7,8,13 noduloulcerative, and nodular.' These lesions have been histologically diagnosed as squamous cell carcinomas.2,7,13 Carca...

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Section: Discussionmentioning

confidence: 99%

Avian Keratoacanthoma (Dermal Squamous Cell Carcinoma) in Broiler Chicken Carcasses

Hafner

Harmon

Stewart³

et al. 1993

Vet Pathol

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“…Recent work has confirmed the efficacy of 412 systemically-administered formalin-inactivated papilloma extract (Bell et al, 1994). Successful vaccination with "live" 413 COPV extract, however, was occasionally associated with development of squamous cell carcinoma or other 414 neoplasms at the injection site (Bregman et al, 1987;Meunier, 1990). 415…”

Section: Heterogenous Wart Extracts 406mentioning

confidence: 99%

The immunology of animal papillomaviruses

Nicholls

Stanley

2000

Veterinary Immunology and Immunopathology

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13Papillomaviruses are species-and tissue-specific double-stranded DNA viruses. These viruses cause epithelial tumours 14 in many animals, including man. Typically, the benign warts undergo spontaneous, immune-mediated regression, most 15 likely effected by T cells (especially CD4, but also CD8 subsets), whereas humoral immunity can prevent new 16 infections. Some papillomavirus infections fail to regress spontaneously, and others progress to malignant epithelial 17 tumours. Additionally, the impact of these lesions is greater in immunosuppressed individuals. Many therapies are 18 ineffective, and there is much interest in the potential for immunological intervention in papillomavirus infections of 19 man and animals. Vaccination can be achieved with 'live' virus, formalin-inactivated virus, synthetic virus-like 20 particles, and DNA vaccination. There has been much recent progress in the development of such vaccines for 21 papillomavirus infections in the rabbit, ox and dog. Success in these animal models suggests that similar approaches 22 may prove useful for prophylactic or therapeutic vaccination against the important human papillomaviruses involved in 23 the development of cutaneous and anogenital warts, laryngeal papillomatosis, and cervical cancer. 24 25

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“…3,8 Although most viral papillomas affect oral mucous membranes in dogs, experimental induction of virus-associated cutaneous papillomas has been described. 2,11 In 1 young dog, oral and cutaneous papillomatosis developed after corticosteroid treatment, and demodecosis accompanied the onset of papillomatosis, suggesting immunocompromise as the underlying risk factor. 10 In a recent report, a 6-year-old dog that had undergone a long course of corticosteroid treatment for atopic dermatitis developed pigmented cutaneous papules containing papillomavirus, and the virus was different from previously described canine oral papillomavirus by molecular studies.…”

Section: Cutaneous Papillomatosis In a Dog With Malignant Lymphoma Fomentioning

confidence: 99%

Cutaneous Papillomatosis in a Dog with Malignant Lymphoma following Long-Term Chemotherapy

et al. 1998

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Cutaneous Neoplasms in Dogs Associated with Canine Oral Papillomavirus Vaccine

Cited by 71 publications

References 13 publications

Avian Keratoacanthoma (Dermal Squamous Cell Carcinoma) in Broiler Chicken Carcasses

Avian Keratoacanthoma (Dermal Squamous Cell Carcinoma) in Broiler Chicken Carcasses

The immunology of animal papillomaviruses

Cutaneous Papillomatosis in a Dog with Malignant Lymphoma following Long-Term Chemotherapy

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