Cutaneous myoepithelioma of the foot

Swali, Ritu; Nwannunu, Crystal E; Farooq, Sahira; Wu, Wesley; Robare, Samantha; Patel, Anisha B.; Tyring, Stephen K.

doi:10.1111/ijd.14734

Cited by 3 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tumors with similar morphologic appearances have been documented to affect acral sites previously in individual case reports or as a part of larger series, but their predilection for acral skin has not been emphasized yet 11,21–26. In addition, Antonescu and colleagues reported similar tumors as “skin and soft tissue myoepitheliomas with ductal differentiation.” They reported a marked predilection for acral skin with 8 of 13 tumors involving the hands or feet with frequent PLAG1 rearrangement, analogous to salivary gland pleomorphic adenomas 7.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Myoepithelial Neoplasms on Acral Sites Show Distinctive and Reproducible Histopathologic and Immunohistochemical Features

Mehta¹,

Davey

Gharpuray-Pandit

et al. 2022

American Journal of Surgical Pathology

View full text Add to dashboard Cite

Cutaneous myoepithelial neoplasms are a heterogenous group of neoplasms with mixed tumors typically affecting the head and myoepitheliomas showing a predilection for the extremities. Their malignant counterparts, myoepithelial carcinoma, and malignant mixed tumor are exceptionally rare in the skin, and the morphologic criteria for malignancy are only poorly defined. The aim of the present study was to characterize the clinicopathologic features of myoepithelial neoplasms presenting on acral skin. The clinical and histopathologic features of 11 tumors were recorded, and follow-up was obtained. Immunohistochemistry was performed for S100, SOX10, glial fibrillary acidic protein, keratins, epithelial membrane antigen, p63, p40, smooth muscle actin, desmin, and PLAG1. The tumors mainly affected the feet of adults (range: 26 to 78 y; median: 47 y) with a predilection for the great toe and a male predominance of 1.8:1. Most tumors (91%) displayed a lobular architecture composed of solid and nested growth of epithelioid cells with plasmacytoid features in a myxoid or angiomatous stroma. Scattered cytologic atypia and rare duct differentiation were frequently noted. Three tumors with confluent cytologic atypia, infiltrative growth, and lymphovascular invasion were classified as malignant. By immunohistochemistry, the tumors were positive for S100, SOX10, keratins AE1/AE3, CK5/6 and CK7, and PLAG1. Local recurrence and bilateral pulmonary metastasis were observed in a patient presenting with a histopathologically benign-appearing tumor. Two patients with malignant tumors experienced local recurrences, and 1 developed metastasis to soft tissue, lung, and mediastinal lymph nodes. All patients are currently alive, all but 1 with no evidence of disease after a median follow-up interval of 96 months (range: 2 to 360 mo). In conclusion, acral myoepithelial neoplasms show distinctive and reproducible histopathologic and immunohistochemical features. They are best regarded as a distinctive subset of mixed tumors with features reminiscent of their salivary gland counterparts. While most tumors pursue a benign disease course, histopathologic features appear to be a poor indicator of prognosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Cutaneous Myoepithelial Neoplasms on Acral Sites Show Distinctive and Reproducible Histopathologic and Immunohistochemical Features

Mehta¹,

Davey

Gharpuray-Pandit

et al. 2022

American Journal of Surgical Pathology

View full text Add to dashboard Cite

show abstract

“…Swali et al reported a CM occurring on the medial aspect of the right foot in a 39-year old Hispanic male. The tumor showed poorly defined architecture with cells arranged in fascicles and nodules [20]. To date, only one case with a plexiform pattern has been reported [10].…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Myoepithelioma: An Unusual Tumor in the Hand

Montalvo

Redrobán

Galarza

et al. 2020

Case Reports in Pathology

View full text Add to dashboard Cite

show abstract

Benign soft-tissue myoepithelioma of the tip of the toe: a case report and literature review

Borazjani

Dehghanian

Taheri

et al. 2020

Current Orthopaedic Practice

View full text Add to dashboard Cite

Myoepithelioma is a rare tumor that mainly affects the salivary glands, with predilection to the parotid glands. A 36-year-old female patient presented with a slow-growing, painless mass on the tip of her right fourth toe that had started 2 yr before being referred to the outpatient orthopaedic clinic. The patient was unable to wear her usual shoes. On physical examination, a firm, non-tender, well-demarcated mass was palpated deeply on the tip of her right fourth toe. Excisional biopsy found a benign soft-tissue myoepithelioma. This study showed the importance of considering myoepithelioma tumor in differentials of the toe and foot masses to avoid misdiagnosis of this rare tumor.

show abstract

Cutaneous myoepithelioma of the foot

Cited by 3 publications

References 5 publications

Cutaneous Myoepithelial Neoplasms on Acral Sites Show Distinctive and Reproducible Histopathologic and Immunohistochemical Features

Cutaneous Myoepithelial Neoplasms on Acral Sites Show Distinctive and Reproducible Histopathologic and Immunohistochemical Features

Cutaneous Myoepithelioma: An Unusual Tumor in the Hand

Benign soft-tissue myoepithelioma of the tip of the toe: a case report and literature review

Contact Info

Product

Resources

About