Cutaneous Metastatic Undifferentiated Pleomorphic Sarcoma from a Mediastinal Sarcoma

Abstract

Undifferentiated pleomorphic sarcoma, known as malignant fibrous histiocytoma, is a malignant neoplasm that arises in both soft tissue and bones. In 2002, the World Health Organization declassified malignant fibrous histocytoma as a formal diagnostic entity and renamed it 'undifferentiated pleomorphic sarcoma not otherwise specified.' It most commonly occurs in the lower extremities and rarely metastasizes cutaneously. We report a case of cutaneous metastatic undifferentiated pleomorphic sarcoma of the buttocks occurring in a 73-year-old man diagnosed with mediastinal sarcoma 4 years previously. He first noticed the mass approximately 2 months previously. Histological findings with immunomarkers led to a final diagnosis of cutaneous metastatic sarcoma from mediastinal undifferentiated pleomorphic sarcoma.

Cutaneous acrometastasis from an undifferentiated pleomorphic sarcoma with giant cells

“…6 The appearance of cutaneous metastases from undifferentiated pleomorphic sarcoma has been described in the literature as an ulcerated or skincolored nodule with associated swelling. [7][8][9][10]12 Although we could not find cases simulating a pyogenic granuloma-type tumor, Gounder et al reported a primary case in the palpebral conjunctiva that actually resembled one. 13 An exceptional metastatic undifferentiated pleomorphic sarcoma with giant cells to the acral skin is presented,…”

“…6 Cutaneous metastases in relation with sarcomas are rare (0.26% of all sarcoma cases), leiomyosarcoma being the commonest comprising 43% of all sarcomas with cutaneous metastases, while those caused by undifferentiated pleomorphic sarcoma constituted up to 6% of them, with only seventeen cases reported in English literature to our knowledge, where only two were located on the toes. [7][8][9][10][11][12] Cases of angiomatous form that simulate pyogenic granuloma have been described in relation to cutaneous metastases of renal, hepatic and thyroid carcinomas. 5 Acral cutaneous metastases tend to present as an erythematous and intensely painful swollen finger.…”

A rare case of acute embolic stroke related with undifferentiated pleomorphic sarcoma

“…Other common sites for distant metastasis include bone (8%), liver (1%), cutaneous tissue (0.6%-1.5%), and brain (1.5%). 4 Patients with brain metastasis usually remain asymptomatic or present as intracranial hemorrhages. 5 However, the presentation of sarcoma as an embolic stroke as illustrated in our case is extremely rare.…”

Undifferentiated pleomorphic sarcoma: Diagnosis of exclusion

“…Undifferentiated pleomorphic sarcomas have high incidence of local recurrence and metastasis. [1] Accounting for <5% of adult soft-tissue sarcomas, [2] these neoplasms have also been reported in children. [3] Individuals in the age group of 50-70 years are mostly affected with common site being the lower extremities.…”

“…[3] Individuals in the age group of 50-70 years are mostly affected with common site being the lower extremities. [4] However, there have been reports of other rare sites involved by these neoplasms such as retroperitoneum [4] male breast, [5] mediastinum, [1] cutaneous, [6] and pelvic region. [7] CONCLUSION These undifferentiated sarcomas are tumors which do not show distinct line of differentiation and obvious morphological features on histopathology.…”