Cutaneous Metastatic Disease in Cervical Cancer: A Case Report

Agrawal, Anita; Yau, Annie; Magliocco, Anthony M.; Chu, Pamela

doi:10.1016/s1701-2163(16)34501-7

Cited by 27 publications

(50 citation statements)

References 23 publications

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“…In general, women with this late manifestation of advanced disease have a very poor prognosis, with survival documented between one week and five years after diagnosis [15] . Our patient was lost to follow-up, and ultimately, her length of survival is unknown.…”

Section: Discussionmentioning

confidence: 99%

“…This case, however, is distinctive for several reasons. First, in prior reports of cutaneous metastases from cervical squamous cell carcinoma, the grossly visible nodules are usually single or a small cluster of multiple papules [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] . In our patient's case, the cutaneous metastases were innumerable and located diffusely over the anterior abdominal wall, vulva, perineum, and bilateral proximal lower extremities (see Figure 1).…”

Section: Discussionmentioning

confidence: 99%

“…In our patient's case, the cutaneous metastases were innumerable and located diffusely over the anterior abdominal wall, vulva, perineum, and bilateral proximal lower extremities (see Figure 1). Secondly, the majority of reports documenting cutaneous cervical SCC metastases state that the appearance of cutaneous involvement occurred despite appropriate treatment, usually as a sign of recurrent disease [15] . Our patient had received no treatment, and this is likely why she presented with extensive, grossly apparent metastatic disease.…”

Section: Discussionmentioning

confidence: 99%

“…This clinical scenario is even less common in literature originating from the United States, due to the lower overall incidence of cervical cancer [3][4][5] . Case reports have documented various sites of cutaneous metastases, including the face and neck [6] , scalp [7][8][9] , vulva [5,[10][11] , upper and lower extremities [12][13] , umbilicus (Sister Mary Joseph nodule) [14] , trunk/abdominal wall [3][4][5]15] , and surgical incision/drain sites [16][17] . Prior authors have found that the occurrence of metastases to the skin generally implies terminal disease, with the average survival following diagnosis ranging from 3-6 months, even in cases where palliative chemo-and radiotherapy are administered [15] .…”

Section: Introductionmentioning

confidence: 99%

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Cutaneous metastases from cervical squamous cell carcinoma in a 55 year-old woman: a rarely reported manifestation

McCarthy

Laucirica

2014

CRCP

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Squamous cell carcinoma of the cervix was once the most common gynecologic cancer in the world, accounting for significant morbidity and mortality. With the advent of routine Papanicolaou screening in the United States during the latter half of the twentieth century, cervical cancer now accounts for a much smaller proportion of cancer deaths. Despite the advances that have been made in screening and early detection, women of low socio-economic status and immigrants from other countries who may not have access to health care continue to present with high-stage disease. Manifestations of advanced disease include direct invasion of structures adjacent to the cervix and distant metastases to the lung, bone, and liver. In approximately 0.5-1 percent of cases, metastases to the skin and soft tissue occur, most commonly to the abdominal wall and vulva, followed less frequently by the perineum and extremities. This particular manifestation has come to be regarded as a sign of terminal disease, with most patients surviving 3-6 months despite chemotherapy. Clinically, this may not be a diagnosis that is anticipated by the pathologist examining the biopsy. We present the case of a 55 year-old woman with a history of untreated squamous cell carcinoma of the cervix who presented with rapidly spreading, painful erythematous papules of the vulva, lower anterior abdominal wall, and proximal lower extremities. This case highlights a rare presentation of metastatic squamous cell carcinoma of the cervix, and underscores the importance of obtaining adequate clinical history, investigating a wide range of diagnoses as part of the differential diagnosis, and distinguishing primary cutaneous squamous cell carcinoma from a metastasis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cutaneous metastases from cervical squamous cell carcinoma in a 55 year-old woman: a rarely reported manifestation

McCarthy

Laucirica

2014

CRCP

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“…Rare sites of metastasis are orbits, brain, skin, spleen and muscle [2][3][4][5][6]. Metastasis to the gastrointestinal tract and particularly to the colon is extremely uncommon.…”

Section: Discussionmentioning

confidence: 99%

Metastatic Squamous Cell Carcinoma of Colon Presenting as a Parietal Abscess

Dey

Dhawan

Malik

2012

Indian J Surg Oncol

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Metastatic squamous cell carcinoma of the gastrointestinal tract is relatively uncommon. It is associated with a poor prognosis and behaves more aggressively. We report a case of metastatic growth in the ascending flexure of the colon that had eroded into the anterior abdominal wall muscles and resulted in a large parietal abscess. She had undergone radical hysterectomy followed by radiation therapy for stage II carcinoma of the uterine cervix 14 months back. Ultrasound guided drainage of the abscess was done as an emergency procedure to control the sepsis. After 3 days an extended Right Hemicolectomy with stapled ileo colic anastomosis was done with resection of a part of abdominal wall adherent to the growth with a grossly normal margin. Histopathological examination confirmed metastatic squamous cell carcinoma. She is disease free 2 months after surgery. Surgical management of the metastatic tumour was palliative but necessary to prevent intestinal obstruction in future.

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