Cutaneous metastasis: experience from a tertiary healthcare institution in Singapore

Mok, Zhun Rui; Yong, Adeline Mei-Yen; Leung, An J.; Tan, Kong Bing; Aw, Derrick Chen-Wee

doi:10.1111/ijd.13650

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…In addition, the frequency of CM from breast cancer corresponded to the frequency of histologic and molecular subtypes of primary breast cancer. Previous studies on different ethnic groups, including a Korean study, reported similar results regarding correspondence between CM frequency and the overall incidence of primary malignant tumors [ 10 , 12 - 15 , 17 , 18 ].…”

Section: Discussionsupporting

confidence: 61%

Clinicopathologic features of cutaneous metastases from internal malignancies

Kwon

Kim

Shin

et al. 2021

J Pathol Transl Med

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Background: Cutaneous metastasis (CM) is the spread of cancer cells from a primary site to the skin and is rarely the first sign of silent cancer. We investigated the clinicopathological characteristics of CM from internal malignancies in Korean patients treated at our institution over 20 years. Methods: The clinicopathological findings of 112 patients (62 females, 50 males) with CM diagnosed at Yeungnam University Hospital between 2000 and 2020 were retrospectively reviewed. Results: Mean patient age was 58.6 years (range, 26 to 87 years), and the most common primary cancer site was breast (74.2%) in women and lung (36.0%) in men. Ninety-six patients (85.7%) presented with CM after primary tumor diagnosis. CM from the lung or biliary tract usually occurred within 2 years of primary tumor diagnosis, whereas metastases from the breast and kidney occurred several years later. The chest, abdomen, and scalp were common sites of CM. Breast cancer usually metastasized to chest skin, while gastrointestinal tract cancers commonly metastasized to the abdomen. The scalp was a common location for CM from various tumors. The most common dermatologic presentations were nodules and masses. Immunohistochemical studies helped identify underlying malignancies when primary tumors were unknown.Conclusions: The relative frequency of CM parallels the overall incidence of primary malignant tumors, and CMs usually occur at anatomic sites close to the primary tumor. CM can be diagnosed based on clinical, radiological, and histological features; however, immunohistochemical study is required in some cases.

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