Clinicopathological study of Korean patients with cutaneous metastasis from internal malignancies

Choi, Myoung Eun; Jung, Chang Jin; Lee, Woojin; Won, Chong Hyun; Chang, Sung Eun; Choi, Jee Ho; Lee, Mi Woo

doi:10.1111/ajd.13135

Cited by 4 publications

(19 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the frequency of CM from breast cancer corresponded to the frequency of histologic and molecular subtypes of primary breast cancer. Previous studies on different ethnic groups, including a Korean study, reported similar results regarding correspondence between CM frequency and the overall incidence of primary malignant tumors [ 10 , 12 - 15 , 17 , 18 ].…”

Section: Discussionsupporting

confidence: 63%

“…While single case reports of CM from various cancers have been reported in Korea [ 1 - 9 ], systematic reviews on the common clinical and morphological presentations and histological subtypes of CM are rare. A recent Korean study reviewed data from 401 patients with CM and reported that the two most common primary cancers were breast and lung cancer [ 10 ], and this finding was consistent with those of studies conducted in other ethnic groups [ 11 - 15 ].…”

supporting

confidence: 75%

“…For example, CM from lung and biliary tract cancers usually occurred within two years of primary diagnosis, whereas CM from breast cancer and hepatocellular and renal cell carcinoma occurred several years after primary diagnosis. Choi et al [ 10 ] also reported that CM occurred several years (mean, 48.2 months) after diagnosis of hepatocellular carcinoma, while lung and pancreatic cancers metastasized to the skin within one year of primary diagnosis. Furthermore, it was reported in a Taiwanese study that CM occurred early in lung cancer (mean, 15.7 months; range, 1 month to 5 years) but several years after breast cancer excision (mean, 47.2 months; range, 1 month to 10 years) [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Clinicopathologic features of cutaneous metastases from internal malignancies

Kwon

Kim

Shin

et al. 2021

J Pathol Transl Med

View full text Add to dashboard Cite

Background: Cutaneous metastasis (CM) is the spread of cancer cells from a primary site to the skin and is rarely the first sign of silent cancer. We investigated the clinicopathological characteristics of CM from internal malignancies in Korean patients treated at our institution over 20 years. Methods: The clinicopathological findings of 112 patients (62 females, 50 males) with CM diagnosed at Yeungnam University Hospital between 2000 and 2020 were retrospectively reviewed. Results: Mean patient age was 58.6 years (range, 26 to 87 years), and the most common primary cancer site was breast (74.2%) in women and lung (36.0%) in men. Ninety-six patients (85.7%) presented with CM after primary tumor diagnosis. CM from the lung or biliary tract usually occurred within 2 years of primary tumor diagnosis, whereas metastases from the breast and kidney occurred several years later. The chest, abdomen, and scalp were common sites of CM. Breast cancer usually metastasized to chest skin, while gastrointestinal tract cancers commonly metastasized to the abdomen. The scalp was a common location for CM from various tumors. The most common dermatologic presentations were nodules and masses. Immunohistochemical studies helped identify underlying malignancies when primary tumors were unknown.Conclusions: The relative frequency of CM parallels the overall incidence of primary malignant tumors, and CMs usually occur at anatomic sites close to the primary tumor. CM can be diagnosed based on clinical, radiological, and histological features; however, immunohistochemical study is required in some cases.

show abstract

Section: Discussionsupporting

confidence: 63%

supporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clinicopathologic features of cutaneous metastases from internal malignancies

Kwon

Kim

Shin

et al. 2021

J Pathol Transl Med

View full text Add to dashboard Cite

show abstract

“…Excluding primary cutaneous malignancies, breast cancer is the most common cause of skin metastasis. In women, breast carcinoma accounts for 64.5%-70% of all skin metastasis, 49 followed by lung (8.2%) and ovarian cancer (5.0%). 49 In men, the most common cause of skin metastasis is lung cancer (12%-20.5%), followed by stomach 13.1% and hepatocellular carcinoma (11.5%).…”

Section: Discussionmentioning

confidence: 99%

“…In women, breast carcinoma accounts for 64.5%-70% of all skin metastasis, 49 followed by lung (8.2%) and ovarian cancer (5.0%). 49 In men, the most common cause of skin metastasis is lung cancer (12%-20.5%), followed by stomach 13.1% and hepatocellular carcinoma (11.5%). 49 In children, neuroblastoma, leukemia, and rhabdomyosarcoma are the most common causes of skin metastasis.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Metastasis From Parotid Tumors: A Report of 2 Cases and Literature Review

Puerto

Jaque

González-Bombardiere³

et al. 2021

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Cutaneous metastases from parotid tumors are uncommon and imply a poor prognosis. In this article, we report 2 new cutaneous metastasis cases from 2 different parotid malignancies and 42 additional cases from a literature review. Clinical manifestations, localization, and outcomes of skin metastasis from parotid tumors are described. Although infrequent, parotid neoplasms may develop skin metastasis many years after the initial diagnosis, mostly in the head and neck region. Therefore, long-term follow-up and periodic skin examination of these patients is mandatory. Dermatologists and surgeons must have a high index of suspicion when evaluating any skin lesion arising on these patients because cutaneous metastasis from parotid neoplasms generally implies a poor prognosis.

show abstract

Cutaneous metastases of internal malignancies: a single‐institution experience

Vernemmen

Roemen

et al. 2022

Histopathology

View full text Add to dashboard Cite

Aims Cutaneous metastases of internal malignancies occur in 1–10% of cancer patients. The diagnosis can sometimes be challenging, especially in cases with an unknown primary cancer. Materials and methods A retrospective case review was performed including all cases of skin metastases from primary internal malignancies diagnosed at the Department of Pathology at the Maastricht University Medical Centre+ from 2007 to 2021. The clinicopathological data were collected and immunohistochemical and molecular diagnostic tests were performed to confirm the primary origin of the metastases. Results We identified 152 cases (71 female; 31 male patients) of cutaneous metastases of internal malignancies. 28 patients (20 women and 8 men) were diagnosed with multiple cutaneous metastases. Among the female patients, the most common primary tumour was breast cancer (50% of the cases), followed by lung (13.6%), gynaecological (7.3%), and gastrointestinal origin (7.3%). Among the male patients, the most common primary sites were gastrointestinal and lung origin (altogether, 50% of the cases). In 19 patients, the cutaneous metastasis was the first presentation of a clinically silent internal malignancy (18.6%), of which most (78.9%) represented metastatic lung carcinomas. Finally, metastasizing patterns were different across tumour types and gender. Conclusion Breast, lung, gastrointestinal, and gynaecologic cancers are the most common primary tumours demonstrating skin metastases. Infrequently, cutaneous metastases can be the first clinically visual manifestation of an underlying not yet diagnosed internal malignancy; therefore, occasional broad immunohistochemical profiling, molecular clonal analysis, and a continuous high level of awareness are necessary for a precise diagnosis of cutaneous metastases of internal malignancies.

show abstract

Clinicopathological study of Korean patients with cutaneous metastasis from internal malignancies

Cited by 4 publications

References 10 publications

Clinicopathologic features of cutaneous metastases from internal malignancies

Clinicopathologic features of cutaneous metastases from internal malignancies

Cutaneous Metastasis From Parotid Tumors: A Report of 2 Cases and Literature Review

Cutaneous metastases of internal malignancies: a single‐institution experience

Contact Info

Product

Resources

About