Cutaneous metastases secondary to pancreatic cancer

Abstract

AIM:To evaluate prognoses after cutaneous metastases, derived from pancreatic cancer. METHODS:We treated two patients with cutaneous metastases from pancreatic cancer. We reviewed 40 reported patients in addition to our cases and analyzed clinical features of cutaneous metastases from pancreatic cancer. RESULTS:The median survival time (MST) was 5 mo after diagnoses of cutaneous metastases. The cumulative 2-year survival rate was 3.5%. The most frequent site of cutaneous metastases was the umbilicus. The MST of patients who were treated with chemotherapy or chemoradiotherapy (CRT) was 6.5 mo, which was statistically longer in comparison to patients without treatment. Prognoses of cutaneous metastases are similar to other metastatic sites from pancreatic cancer. Receiving chemotherapy or CRT was the only prognostic factor of cutaneous metastases from pancreatic cancer. CONCLUSION:The prognoses of cutaneous metastases are similar to other metastatic pancreatic cancers. Receiving chemotherapy or CRT was the only prognostic factor of cutaneous metastases from pancreatic cancer.

Metastatic pancreatic adenocarcinoma to the scrotum

“…This is consistent with reports that cutaneous manifestations most frequently are reported at locations in the vicinity of the primary tumor. [1] The gastrointestinal tract (encompassing origins in the colon/rectum and stomach) was also shown to be the second most common organ system responsible (11 of 29), and to our knowledge, none of those cases reported have been described as pancreatic in origin.…”

“…[2] Also, in reviewing 22 cases of cutaneous metastatic pancreatic cancer, in 11 of the cases, the metastatic lesions to the skin were the first symptoms of pancreatic cancer. [1] The incidence of cutaneous metastatic manifestations of pancreatic cancer has been estimated at 2.0%, and the most frequent site of metastasis was the umbilicus, known as Sister Mary Joseph's nodule. [1] Again, these reports substantiate that metastases are often near the site of the primary tumor.…”

“…[1] The incidence of cutaneous metastatic manifestations of pancreatic cancer has been estimated at 2.0%, and the most frequent site of metastasis was the umbilicus, known as Sister Mary Joseph's nodule. [1] Again, these reports substantiate that metastases are often near the site of the primary tumor. It is not uncommon, however, for distal metastases; 39% of patients noted to have cutaneous metastases in Lookingbill et al's Figure 1.…”

“…Skin metastases represent a grave prognostic sign [1] , and most patients survive less than a year after appearance of skin lesions. Most recent data generally indicates survival is typically four months or less after appearance of cutaneous metastases to the scrotum.…”

“…While cutaneous metastases from primary malignancies are not uncommon, metastasis to the scrotum is a seldom seen. In a retrospective study of 4020 patients with metastatic carcinoma [1] the overall incidence of cutaneous metastasis was 10%, of whom only one patient developed metastasis to the scrotum (0.02%).…”