Cutaneous metastases of malignant peripheral nerve sheath tumor: Ineffectiveness of intralesional methotrexate

Soft tissue sarcoma in neurofibromatosis type 1: A rare case of malignant peripheral nerve sheath tumor of the skin

“…Other factors include tumor grade, surgical margin, local recurrence, histological malignancy, cell polymorphism, and mitotic activity [3,5]. Previous studies have reported that a clear surgical margin is the most important factor involved in the survival of patients with C-MPNST [14,15]. Accordingly, our patient survived the 15-month follow-up period without recurrence or metastasis after complete resection with a negative margin.…”

“…Previous studies have reported that a clear surgical margin is the most important factor involved in the survival of patients with C-MPNST 14 15 . Accordingly, our patient survived the 15-month follow-up period without recurrence or metastasis after complete resection with a negative margin.…”

Resolution of Keratoacanthoma Type Squamous Cell Carcinoma Following Intralesional Therapy With Methotrexate

“…Previous studies showed a high success rate of intralesional methotrexate for the treatment of keratoacanthoma [4]. Intralesional methotrexate has also been used for the treatment of nail psoriasis, basal cell carcinoma, nodular cutaneous amyloidosis, and pyoderma gangrenosum, but it has been ineffective in the treatment of cutaneous metastases of malignant peripheral nerve sheath tumors [5,6]. Methotrexate is relatively inexpensive and should be taken into consideration when choosing an intralesional agent for keratoacanthoma-type squamous cell carcinoma.…”

The Role of Surgery in Oligometastatic Retroperitoneal Sarcoma

“…High (20-40%) [11,14] Very Low (1-3%) [9,16] Low (10%) [9,16] Intra-Abdominal [17] 5-yr: 89% [18] 10-yr: 70% [11] DDLPS High (40-58%) [11,14] Low for Grade I (5-10%) [16,19] Medium for Grade II-III (20-30%) [14] Medium (30%) [11] Intra-abdominal, Lungs [17] 5-yr: 44-50% [18,20] 10-yr: 30-50% [11,14] LMS Low (10-21%) [14,21] High (47%) [14,21] Very High (58%) [14] Lungs [22] 5-yr: 60% [14,18] 10-yr: 40% [11] UPS High (40%) [14] High (31-35%) [14,23] High (50%) [24] Lungs [23] 5-yr: 40-53% [14,23] 10-yr: 45% [24] MPNST Medium (20-35%) [11,14] Low (15%) [14] Low (15%) [14] Lung [25] 5-yr: 51-65% [14,26] 10-yr: 45% [11] SFT Low (8-10%) [11,14] Low (10%)…”