Cutaneous Melanoma in African Albinos: A Systematic Review

Prevalence of Squamous and Basal Cell Carcinomas in African Albino Skin Cancer Lesions: A Systematic Review and Meta-Analysis of Proportion

“…Methods adapted for this review had been previously described in our first manuscript, which focused on cutaneous melanoma [ 18 ].…”

“…The search was conducted on May 28, 2020, and updated on September 2020. The databases were searched iteratively with the following string of key terms: “skin cancer in African albinos,” “cutaneous malignancy in African albinos,” and “skin cancer in Africans.” As this is a second of a two-part report, the full-search strategy used in data acquisition has been detailed in our first publication that focused on melanoma skin cancers [ 18 ].…”

“…The included studies are case series or cross-sectional studies of skin cancer in African albinos. In the included studies, skin cancer lesions must have been histologically classified and African albinos were the overall subject of the study or were identified as a subgroup in a larger sample of Africans [ 18 ]. Excluded were all studies in which the malignant diagnosis was not histologically confirmed and all skin cancer cases in albino individuals not of African descent or of African descent but not reported from Sub-Saharan Africa [ 18 ].…”

“…Data extracted from the articles include author, year of study, country of study, type of study, brief description of study, total number of subjects, no of albinos with skin cancer, sex distribution of albinos with skin cancer, mean and median age of albinos with skin cancer, and histologic types of albino skin cancer. The process of data extraction was independently undertaken by the two authors and disagreements were resolved by discussion and consensus among the authors [ 18 ].…”

“…An aggregate score of 3 or 4 was considered low quality while a score of 5 or 6 was appraised high quality. Discordant assessments were resolved by consensus among the authors ( Table 1 ) [ 18 ].…”