Cutaneous Manifestations of Sarcoidosis Relationships to Other Organ System Involvement, Abnormal Laboratory Measurements, and Disease Course

The skin is the second most common organ affected in sarcoidosis, which can affect patients of all ages and races, with African American women having the highest rates of sarcoidosis in the United States. The cutaneous manifestations are protean and can reflect involvement of sarcoidal granulomas within the lesion or represent reactive non-specific inflammation, as seen with erythema nodosum. Systemic work-up is necessary in any patient with cutaneous involvement of sarcoidal granulomas, and treatment depends on other organ involvement and severity of clinical disease. Skin-directed therapies are first line for mild disease, and immunomodulators or immunosuppressants may be necessary.

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“…3). 1,7,9,10,24,26,27 Compared with macules/ papules, plaque sarcoidosis is more likely to leave dyspigmentation and scarring. …”

Section: Common Morphologiesmentioning

confidence: 99%

Cutaneous Sarcoidosis

Wanat

Rosenbach

2015

Clinics in Chest Medicine

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“…Small papules, 1 to 5 mm in size, are initially orange or yellow-brown in color, turn brownish-red or violaceous, then involute to form faint macules. [27][28][29] This form of sarcoidosis occurs primarily on the face and neck with a predilection for periorbital skin. 5 The number of lesions may be great and hundreds have been reported on a single patient alone.…”

Section: Physical Examination Nonspecific Skin Lesionsmentioning

confidence: 99%

“…33 Scar sarcoidosis often resolves slowly and spontaneously. 29 Minor forms of specific lesions. Psoriasiform.…”

Section: Physical Examination Nonspecific Skin Lesionsmentioning

confidence: 99%

“…5 This rare manifestation presents primarily on the legs of patients with darker skin and unlike psoriasis, heals with scarring. 5,29,35,36 However, hyperpigmented patches may remain.…”

Section: Physical Examination Nonspecific Skin Lesionsmentioning

confidence: 99%

“…7,10,68-70 It is reported that erythema nodosum, more common in Caucasians, is associated with a decreased frequency of respiratory symptoms. 29 The presence of nonerythema nodosum skin lesions is associated with more extensive disease. 29 The prognosis of patients with cutaneous sarcoidosis depends, primarily, upon the extent of systemic involvement.…”

Section: Pulmonary Lesionsmentioning

confidence: 99%

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