Cutaneous Manifestations of Multiple Myeloma

Secondary Cutaneous Plasmacytoma

“…Contrary to the findings previously reported in similar cases [2], no signs of widespread disease were evident; following local radiotherapy, a good response and a long dis ease-free follow-up were observed. A man aged 60 presented in November 1980 with a 2 years' history of a pruriginous, red-colored, episternal skin patch which progressively enlarged from 3 to 20 cm in di ameter.…”

“…Their courses were variable: Some times the disease remained stable for a long period, more often it spread out of the skin to other organs and soft tissues (3, 5). Cutaneous extramedullary plasmacytomas secondary to multiple myeloma or plasma cell leukemia occur more frequently and should be considered as a sign of poor prognosis: The occurrence of cutaneous plasmacytomas ex tending directly from underlying myelomatous bone lesions, as observed in our case, seems to be as un common as that of primary extramedullary tumors [1], In Bluefarb' s [2] series, the largest so far reported, skin changes were associated with multiple osseous lesions, large amounts of M component, and massive bone marrow replacement by plasma cells. …”

Congenital Ichthyosis and Medulloblastoma

“…Most of the reports are cases of acquired ichthyosis and Hodgkin's disease, or with multiple myeloma [1,3,7,9,12]. Rarer are the cases of ichthyosis in relation with malignancy of breast [4,6,12], lung [2,12], reticulum cell sarcoma [12] and Kaposi's sarcoma [5], Ichthyosis since infancy, and Hodgkin's disease is uncommon [3], Ich thyosis with neurological disorders has been seen in the following syndromes:…”

Mitteilungen – Communications Histopathologie des hématodermies

“…Les localisations cutanées des myélomes peuvent être soit le fait de l'ex tension d'une lésion osseuse sous-jacente, soit le fait d'une dissémination; elles sont rares [9 cas sur 88 pour Bluefarb, 1955;I A côté des lésions d'urticaire pigmentaire banales associées à des leucémies, il existe d'exceptionnelles localisations cutanées de mastocytose maligne à cellules volumineuses, à noyau multilobé; les granulations cytoplasmiques métachromatiques n'existent que dans les formes relativement différenciées.…”