Cutaneous manifestations in inflammatory bowel disease: a single institutional study of non‐neoplastic biopsies over 13 years

Ko, Jennifer S.; Uberti, Georgina; Napekoski, Karl M.; Patil, Deepa T.; Billings, Steven D.

doi:10.1111/cup.12777

Cited by 18 publications

(17 citation statements)

References 48 publications

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“…Pyogenic and pustular skin manifestations are common symptoms of an immunodeficiency and an increased susceptibility to bacterial, viral, and/or fungal infections (see section “Infectiology”). However, skin manifestations are also observed in CU and CD exemplified by aphthous stomatitis, gingivitis, cheilitis granulomatosa, erythema nodosum, and pyoderma gangrenosum . Also, it should be kept in mind that skin manifestations are sometimes side effects of immunosuppressive drugs used in IBD therapy.…”

Section: Pid Manifesting With Ibdmentioning

confidence: 99%

Inflammatory bowel disease caused by primary immunodeficiencies—Clinical presentations, review of literature, and proposal of a rational diagnostic algorithm

Tegtmeyer

Seidl

Gerner

et al. 2017

Pediatric Allergy Immunology

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Inflammatory bowel diseases (IBD) including Crohn's disease (CD) and ulcerative colitis have a multifactorial pathogenesis with complex interactions between polygenetic predispositions and environmental factors. However, IBD can also be caused by monogenic diseases, such as primary immunodeficiencies (PID). Recently, an increasing number of these altogether rare diseases have been described to present often primarily, or solely, as IBD. Early recognition of these conditions enables adaption of therapies and thus directly benefits the course of IBDs. Here, we discuss the different clinical presentations in IBD and characteristic features of patient's history, clinical findings, and diagnostic results indicative for a causative PID. Possible predictors are early onset of disease, necessity of parenteral nutrition, failure to respond to standard immunosuppressive therapy, parental consanguinity, increased susceptibility for infections, certain histopathologic findings, and blood tests that are atypical for classic IBD. We illustrate this with exemplary case studies of IBD due to NEMO deficiency, chronic granulomatous disease, common variable immunodeficiency, CTLA-4 and LRBA deficiency. Taking these factors into account, we propose a diagnostic pathway to enable early diagnosis of IBD due to PID.

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Section: Pid Manifesting With Ibdmentioning

confidence: 99%

Inflammatory bowel disease caused by primary immunodeficiencies—Clinical presentations, review of literature, and proposal of a rational diagnostic algorithm

Tegtmeyer

Seidl

Gerner

et al. 2017

Pediatric Allergy Immunology

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“…Much of what is known about cutaneous CD is limited to case reports and small case series. On review of the literature, the histopathological features of cutaneous CD may be considered non‐specific, paralleling the variable clinical manifestations . Consistent findings across the majority of cases include granulomatous inflammation composed of epithelioid histiocytes with a conspicuous lymphocytic infiltrate.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Crohn's disease with superimposed psoriasis: A unique case with overlapping histology

2017

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Crohn's disease (CD) is an idiopathic, chronic inflammatory disorder of the gastrointestinal tract. We recently encountered a unique case in which a patient with longstanding CD presented with skin lesions with histopathologic features of both psoriasis and granulomatous inflammation suggestive of cutaneous CD. To our knowledge, this has not been described concomitantly in the same patient, in the same lesions. Review of the literature suggests that the intersection of these 2 histopathological reaction patterns may not be pure coincidence. Clinical-pathologic correlation of this case will be discussed, along with a review of the potential mechanisms of this unique disease presentation.

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“… 4 A rare association with Crohn’s disease has been documented; this connection is often missed when reviewing mucocutaneous manifestations of inflammatory bowel disease due to the low incidence of dissecting cellulitis itself, as well as its nonfulminant clinical course and the wide array of differential diagnoses that can mask the appropriate diagnosis. 5 , 6 …”

Section: Discussionmentioning

confidence: 99%

Dissecting Cellulitis of the Scalp: A Rare Dermatological Manifestation of Crohnʼs Disease

Syed

Asad

Salem

et al. 2018

ACG Case Reports Journal

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Dissecting cellulitis is an inflammatory disease of the skin. We report a case of recurrent dissecting cellulitis in a patient with Crohn’s disease. A 31-year-old man with a history of purulent scalp lesions presented with night sweats, weight loss, abdominal pain, and hematochezia. Colonoscopy revealed a diffuse friable mucosa with extensive pseudopolyps. Scalp biopsy demonstrated epidermoid inclusion cysts with granulation tissue and chronic inflammatory cell infiltration, indicative of dissecting cellulitis. The incidence of dissecting cellulitis with Crohn’s disease is underreported. This dermatologic condition has a tendency to recur, and considering an underlying disease is key for its appropriate treatment.

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Cutaneous manifestations in inflammatory bowel disease: a single institutional study of non‐neoplastic biopsies over 13 years

Cited by 18 publications

References 48 publications

Inflammatory bowel disease caused by primary immunodeficiencies—Clinical presentations, review of literature, and proposal of a rational diagnostic algorithm

Inflammatory bowel disease caused by primary immunodeficiencies—Clinical presentations, review of literature, and proposal of a rational diagnostic algorithm

Cutaneous Crohn's disease with superimposed psoriasis: A unique case with overlapping histology

Dissecting Cellulitis of the Scalp: A Rare Dermatological Manifestation of Crohnʼs Disease

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