Cutaneous Manifestations in Chronic Lymphocytic Leukemia

Bonvalet, D; Földes, C.; Civatte, J

doi:10.1111/j.1524-4725.1984.tb00899.x

Cited by 50 publications

(30 citation statements)

References 13 publications

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“…Im Gegensatz zur Gingivahyperplasie können Papeln oder Knoten sowie Ulzera der Mundschleimhaut auch bei anderen Leukämieformen auftreten, z. B. bei der CLL [5,52,62].…”

Section: Klinische Befundeunclassified

Leukaemia cutis – Epidemiologie, Klinik und Differenzialdiagnosen

Wagner

Fenchel

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et al. 2011

J Deutsche Derma Gesell

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“…Im Gegensatz zur Gingivahyperplasie können Papeln oder Knoten sowie Ulzera der Mundschleimhaut auch bei anderen Leukämieformen auftreten, z. B. bei der CLL [5,52,62].…”

Section: Klinische Befundeunclassified

Leukaemia cutis – Epidemiologie, Klinik und Differenzialdiagnosen

Wagner

Fenchel

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et al. 2011

J Deutsche Derma Gesell

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“…The literature contains very rare reports of gingival hyperplasia in CML [35]. Unlike gingival hyperplasia, papules or nodules, as well as ulcers of the oral mucosa may also occur in other forms of leukemia such as CLL [5,52,62].…”

Section: Clinical Appearancesmentioning

confidence: 99%

Leukemia cutis – epidemiology, clinical presentation, and differential diagnoses

Wagner

Fenchel

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et al. 2011

J Deutsche Derma Gesell

143

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Keywords• leukemia cutis • acute myeloid leukemia • chronic lymphocytic leukemia • chloroma • myeloid sarcoma • granulocytic sarcoma • gingival hyperplasia Summary Leukemia cutis is an extramedullary manifestation of leukemia. The frequency and age distribution depend on the leukemia subtype. The clinical and morphological findings have a wide range of cutaneous manifestations and may present with nodular lesions and plaques. Rare manifestations include erythematous macules, blisters and ulcers which can each occur alone or in combination. Apart from solitary or grouped lesions, leukemia cutis may also present with an erythematous rash in a polymorphic clinical pattern. Consequently, leukemia cutis has to be distinguished from numerous differential diagnoses, i. e. cutaneous metastases of visceral malignancies, lymphoma, drug eruptions, viral infections, syphilis, ulcers of various origins, and blistering diseases. In the oral mucosa, gingival hyperplasia is the main differential diagnosis. The knowledge of the clinical morphology is of tremendously importance in cases in which leukemia was not yet known.

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“…Chronic lymphocytic leukemia (CLL) is a low-grade clonal B-lineage lymphoid neoplasm that can occasionally involve the skin with specific lesions, most often as papules, plaques, nodules, or large tumors. Erythroderma may also occur [10,11,12]. …”

Section: Introductionmentioning

confidence: 99%

Sézary Syndrome Coexisting with B-Cell Chronic Lymphocytic Leukemia: Case Report and Review of the Literature

et al. 2007

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Introduction: The simultaneous presentation of chronic B-cell lymphocytic leukemia (B-CLL) and cutaneous T-cell lymphoma (CTCL) is extremely rare. Case Report: We describe a patient with B-CLL and Sézary syndrome (SS), an erythrodermic and leukemic variant of CTCL. Despite treatment, the SS progressed to involve internal organs and eventual death of the patient from sepsis. This is the first reported case of SS coexisting with chronic lymphocytic leukemia in which an anti-Vβ13.6 antibody was used to serially track changes in circulating neoplastic T cells vis-à-vis neoplastic B cells and to detect neoplastic T cells in ascitic fluid near the end of the patient’s life. Discussion: We speculate that the coexistence of B-CLL and CTCL is the result of an initiating genetic or epigenetic defect at the level of the common lymphoid stem cell that predisposes both B-cell and T-cell lineages to additional oncogenic changes at a more advanced stage of differentiation.

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Cutaneous Manifestations in Chronic Lymphocytic Leukemia

Cited by 50 publications

References 13 publications

Leukaemia cutis – Epidemiologie, Klinik und Differenzialdiagnosen

Leukaemia cutis – Epidemiologie, Klinik und Differenzialdiagnosen

Leukemia cutis – epidemiology, clinical presentation, and differential diagnoses

Sézary Syndrome Coexisting with B-Cell Chronic Lymphocytic Leukemia: Case Report and Review of the Literature

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