Cutaneous Lymphangitis Carcinomatosa: A Rare Primary Manifestation of Malignancy

Keohane, S.G.; Doherty, V.R.; McLaren, K M; Hunter, John

doi:10.1177/014107689608901012

Cited by 11 publications

(11 citation statements)

References 5 publications

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“…Although a skin metastasis may be an initial symptom (Jang et al 1988;Keohane et al 1996;Emmerst et al 2002), most metastatic skin lesions appear after the primary tumour has been diagnosed. Although a skin metastasis may be an initial symptom (Jang et al 1988;Keohane et al 1996;Emmerst et al 2002), most metastatic skin lesions appear after the primary tumour has been diagnosed.…”

Section: Discussion and Review Of Literaturementioning

confidence: 99%

Cancer-related secondary lymphoedema due to cutaneous lymphangitis carcinomatosa: clinical presentations and review of literature

Damstra

Jagtman

Steijlen

2009

European Journal of Cancer Care

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Lymphoedema is a clinical condition caused by impairment of the lymphatic system, leading to swelling of subcutaneous soft tissues. As a result, accumulation of protein-rich interstitial fluid and lymphostasis often causes additional swelling, fibrosis and adipose tissue hypertrophy leading to progressive morbidity and loss of quality of life for the patient. Lymphoedema can be distinguished as primary or secondary. Lymphoedema is a complication frequently encountered in patients treated for cancer, especially after lymphadenoectomy and/or radiotherapy based on destruction of lymphatics. However, although lymphatic impairment is sometimes caused by obstructive solid metastasis, we present three cases of secondary lymphoedema with minor dermatological features without detectable solid metastasis. Sometimes this type of lymphoedema is mistakenly called malignant lymphoedema. All patients were previously treated for cancer without clinical signs of recurrence, presented with progressive lymphoedema and minor dermatological features of unknown origin. Clinical and histopathological examination of the skin revealed diffuse lymphangitis carcinomatosa, leading to secondary lymphoedema and adjustment of the therapeutic approach and prognosis. We reviewed literature on these rare presentations of cancer recurrence and recommend, where appropriate, consulting a dermatologist when discrete skin abnormalities are seen in patients with a history of cancer and developing lymphoedema.

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Section: Discussion and Review Of Literaturementioning

confidence: 99%

Cancer-related secondary lymphoedema due to cutaneous lymphangitis carcinomatosa: clinical presentations and review of literature

Damstra

Jagtman

Steijlen

2009

European Journal of Cancer Care

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“…The response is rarely complete and sustains <4-5 months and median survival <9 months. Anectodotal cases of cutaneous lymphangitis have an even prognosis with survival rarely >5 months (5)(6)(7) . …”

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confidence: 99%

Extensive subcutaneous metastasis from squamous cell carcinoma of the cervix in patient with HIV

Joseph

Chiramana

2004

Int J Gynecol Cancer

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“…The prognosis of cutaneous lymphangitis carcinomatosa is very poor with a mean survival of 3 months after diagnosis of cutaneous deposits 12 13…”

Section: Discussionmentioning

confidence: 99%

Rapidly lethal dermatomyositis associated with cutaneous lymphangitis carcinomatosa

et al. 2013

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SUMMARYA 70-year-old woman with a recent diagnosis of dermatomyositis (DM) presented to the dermatology department for study of a probably paraneoplastic syndrome. On examination, we observed discrete, indurated, reddish, painful plaques and nodules on her abdomen and both thighs. A cutaneous biopsy from an abdominal nodule, performed as part of the paraneoplastic workup, was suggestive of cutaneous lymphangitis carcinomatosa, secondary to unknown malignancy. An extensive investigation to locate the site of the primary tumour revealed no specific findings. A course of palliative chemotherapy with cisplatin and 5-fluorouracil was then given, but the patient's condition deteriorated and 6 months after her initial observation the patient died. We describe this case because, to our knowledge, the association between DM and cutaneous lymphangitis carcinomatosa has not been described yet in the literature and to highlight that, DM can be a rapidly lethal disease. BACKGROUND

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Cutaneous Lymphangitis Carcinomatosa: A Rare Primary Manifestation of Malignancy

Cited by 11 publications

References 5 publications

Cancer-related secondary lymphoedema due to cutaneous lymphangitis carcinomatosa: clinical presentations and review of literature

Cancer-related secondary lymphoedema due to cutaneous lymphangitis carcinomatosa: clinical presentations and review of literature

Extensive subcutaneous metastasis from squamous cell carcinoma of the cervix in patient with HIV

Rapidly lethal dermatomyositis associated with cutaneous lymphangitis carcinomatosa

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