Extensive subcutaneous metastasis from squamous cell carcinoma of the cervix in patient with HIV

Joseph, B.; Chiramana, H.

doi:10.1136/ijgc-00009577-200401000-00027

Cited by 2 publications

(2 citation statements)

References 5 publications

(5 reference statements)

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“…The 9v has been shown to be effective to prevent infections of the genotypes included in the vaccine, but it is still debated whether it provides protection against other genotypes. This is a remarkable limitation, as the persistent HPV infections observed in HIV-positive women are caused by a broad diversity of both HR and LR types (Joseph and Chiramana, 2004;De Vuyst et al, 2008;McClymont et al, 2020). These data are confirmed also by the present study: 49% of infections were represented by non9v HPV types (Figure 1).…”

Section: Discussionsupporting

confidence: 85%

“…In HIVpositive women, ICC arises 10-15 years sooner in comparison to HIV-negative women, and it has a worse prognosis. HAART therapy and the increase in CD4 T cell counts do not appear to influence the course of the malignancy (Joseph and Chiramana, 2004;Pantanowitz et al, 2010). The 9v has been shown to be effective to prevent infections of the genotypes included in the vaccine, but it is still debated whether it provides protection against other genotypes.…”

Section: Discussionmentioning

confidence: 99%

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Human Papillomavirus Infections in Cervical Samples From HIV-Positive Women: Evaluation of the Presence of the Nonavalent HPV Genotypes and Genetic Diversity

et al. 2020

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Non-nonavalent vaccine (9v) Human papillomavirus (HPV) types have been shown to have high prevalence among HIV-positive women. Here, 1444 cervical samples were tested for HPV DNA positivity. Co-infections of the 9v HPV types with other HPV types were evaluated. The HPV81 L1 and L2 genes were used to investigate the genetic variability of antigenic epitopes. HPV-positive samples were genotyped using the HPVCLART2 assay. The L1 and L2 protein sequences were analyzed using a self-optimized prediction method to predict their secondary structure. Co-occurrence probabilities of the 9v HPV types were calculated. Non9v types represented 49% of the HPV infections; 31.2% of the non9v HPV types were among the low-grade squamous intraepithelial lesion samples, and 27.3% among the high-grade squamous intraepithelial lesion samples, and several genotypes were low risk. The co-occurrence of 9v HPV types with the other genotypes was not correlated with the filogenetic distance. HPV81 showed an amino-acid substitution within the BC loop (N75Q) and the FGb loop (T315N). In the L2 protein, all of the mutations were located outside antigenic sites. The weak cross-protection of the 9v types suggests the relevance of a sustainable and effective screening program, which should be implemented by HPV DNA testing that does not include only high-risk types.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus Infections in Cervical Samples From HIV-Positive Women: Evaluation of the Presence of the Nonavalent HPV Genotypes and Genetic Diversity

et al. 2020

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Clinical characteristics of cervical cancer in patients infected with human immunodeficiency virus

Кедрова

Shumeykina

Красильников

et al. 2023

Opuholi ženskoj reproduktivnoj sistemy

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Background. Infection caused by human immunodeficiency virus (HIV) is a slowly developing anthroponosis with a long course and a variety of clinical manifestations, which finally results in acquired immunodeficiency syndrome (AIDS). Over the past 4 decades, the HIV / AIDS pandemic has been considered as one of the world’s most serious public health problems. Globally, there were approximately 38 million people living with HIV in 2022; 53 % of them were women. The number of HIV-infected patients living in Russia reaches 1,168,000. The incidence and prevalence of HIV infectionvaries across different regions of Russia. High prevalence of cervical cancer usually correlates with HIV prevalence, which is associated with the long-term and aggressive persistence of human papillomavirus (HPV) in HIV patients. HIV co-infection is believed to be the main risk factor for HPV-related precancerous lesions to the cervical epithelium and their rapid progression to invasive cancer. Aim. To analyze risk factors for poor prognosis in HIV-infected patients with HPV. Materials and methods. This study included 15 HIV-infected patients with cervical cancer treated in Novosibirsk Regional Clinical Oncology Dispensary or Federal Research and Clinical Center for Specialized Medical Care and Medical Technologies, Federal Biomedical Agency of Russia between 2016 and 2021. Results. Median age of the patients was 38 years; all of them were HPV-positive. Their viral load was >400 copies / mL and baseline CD4+ cell count ≥350 cells / mL. All patients were diagnosed with AIDS, given the presence of HPV infection. During the therapy for cervical cancer, patients also received combination antiretroviral treatment, including Lamivudine Advanced at a dose of 300 mg / day. Ten patients received comprehensive treatment, while 8 patients received chemoradiotherapy. Conclusion. Given the more aggressive course of cervical cancer in HIV-infected patients, their treatment plan should be developed by a multidisciplinary team, including an infectious disease specialist, clinical pharmacologist, radiotherapist, and gynecological oncologist. Such patients should receive maximal antitumor treatment, as well as intensive antiretroviral therapy. HIV-positive women with cervical cancer require special attention to ensure treatment completion and to optimize long-term outcomes.

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Extensive subcutaneous metastasis from squamous cell carcinoma of the cervix in patient with HIV

Cited by 2 publications

References 5 publications

Human Papillomavirus Infections in Cervical Samples From HIV-Positive Women: Evaluation of the Presence of the Nonavalent HPV Genotypes and Genetic Diversity

Human Papillomavirus Infections in Cervical Samples From HIV-Positive Women: Evaluation of the Presence of the Nonavalent HPV Genotypes and Genetic Diversity

Clinical characteristics of cervical cancer in patients infected with human immunodeficiency virus

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