Cutaneous keratocysts of nevoid basal cell carcinoma syndrome

Barr, Ronald J.; Headley, John L.; Jensen, Jerald L.; Howell, J. B.

doi:10.1016/s0190-9622(86)70071-6

Cited by 40 publications

(17 citation statements)

References 6 publications

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“…and the former showing a similar eosinophilic internal cuticle as is seen in steatocystomas. 28 Also present are skeletal anomalies including spinal and rib deformities, excessive ossification with bossing of the frontal skull and bridging of the sella turcica. Calcification of the falx cerebri is another manifestation.…”

Section: Clinical Featuresmentioning

confidence: 99%

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Basal cell carcinoma: biology, morphology and clinical implications

2006

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Basal cell carcinoma (BCC) is the most common malignant neoplasm of humans. Rising dramatically in incidence in North America, as likely reflects changing habits of the population and a move from more northerly climes to the sunbelt of the Southern and Southwestern United States, the incidence is surely to rise even higher in the future. The last decade has seen significant advances in our understanding of BCC biology and novel approaches to therapy, which hinge upon accurate diagnosis and subclassification by pathologists. The purpose of this review article is to summate the research advances in our understanding of BCC biology and to acquaint pathologists and clinicians to the practical issues in BCC diagnosis and subclassification which flow there from.

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Section: Clinical Featuresmentioning

confidence: 99%

“…The epidermal cysts are usually derived from the follicular infundibula with a pronounced keratohyalin granular layer in the internal squamous epithelial lining while in some cases the histology is more cognate to steatocystomata but differs by the absence of sebaceous glands. 28 …”

Section: Histopathologymentioning

confidence: 99%

Basal cell carcinoma: biology, morphology and clinical implications

2006

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“…In contrast, Barr et al[ 15] reported that 2 of 4 cysts were histologically similar to jaw keratocysts. Zackheim et al [11 ]described that a histological feature of skin cysts associated with NBCCS is a wall lined by a stratified epithelium of 4–6 cells’ thickness with a poorly defined granular cell layer.…”

Section: Discussionmentioning

confidence: 96%

“…We summarized the clinical and histological features of 19 NBCCS patients with epidermal cysts reported in the English-language literature between 1966 and 2006 (table 1) [11,12,13,14,15,16,17,18]. Nicolai [14] and Leppard [9] have emphasized that acral localization of the skin cysts is a characteristic feature in NBCCS.…”

Section: Discussionmentioning

confidence: 99%

Multiple Skin Cysts in Nevoid Basal Cell Carcinoma Syndrome: A Case Report and Review of the Literature

Motegi

Nagai²,

Tamura³

et al. 2008

Dermatology

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We report a 72-year-old man with nevoid basal cell carcinoma syndrome (NBCCS) who presented with 25 skin cysts on his trunk and extremities. Fourteen of 25 skin cysts (56%) were observed on his hands. Histological examination demonstrated that most of the excised cysts had an epithelial wall with typical epidermal keratinization. However, 4 skin cysts (4/16; 25%) showed a corrugated or festooned inner surface of wall without a granular cell layer, which resembled an odontogenic keratocyst, a characteristic feature of skin cysts in NBCCS. A review of the literature suggested that acral localization of skin cysts is a distinctive feature of NBCCS. In addition, the histological findings of skin cysts resembling an odontogenic keratocyst might be a hallmark of NBCCS.

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“…Barr et al 8 . described a case of NBCCS forming a cutaneous epidermoid cyst with a histological resemblance to odontogenic keratocysts, in that the cyst wall was composed of several layers of basaloid cells.…”

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confidence: 99%