Cutaneous involvement as the first manifestation of T‐lymphoblastic lymphoma and review of the literature

Abstract

Lymphoblastic lymphomas (LBLs) are uncommon malignant neoplasms derived from immature T‐ or B‐lymphoid progenitor cells. Although cutaneous involvement may reach 33% in B‐LBL, only 12 cutaneous cases of T‐LBL have been published. We report the case of a 49‐year‐old woman with 2‐month history of erythematous‐violaceous plaques in the sternal region and breasts. Histopathologic examination showed a dense monomorphus infiltrate in dermis and positive immunostainings for CD3, CD99 and terminal deoxynucleotidyl transferase, thus indicating T‐LBL. Staging work‐up only revealed a mediastinal mass at diagnosis. After a 51‐month follow‐up and different treatment regimens, the patient remains alive although she has presented four relapses, all of them extramedullary.

Cutis verticis gyrata in a 24 year-old young man revealing a T-cell lymphoblastic lymphoma

“…To our knowledge, only 15 cases of T-LBL with cutaneous involvement have been reported in the literature. 1,4,5 Skin lesions mostly present as nodular lesions, located on the scalp, the trunc and the limbs. Skin lesions in T-LBL usually present as multiple nodules associated with multiple peripheral lymphadenopathy and bone marrow invasion.…”

Specific cutaneous infiltrates in patients with haematological neoplasms: a retrospective study with 49 patients

“…Most LL cases are of T-cell origin (>90%). 15 Precursor B-and T-cell malignancies are primarily seen in children and young adults, with sporadic cases at older ages. 1 Since the characteristics of lymphomas appear to differ widely with geography and ethnicity, larger-scale studies describing the clinical features of SCL are needed.…”

“…Three cases were analysed in this study: 2 of T‐cell origin and 1 of B‐cell origin. Most LL cases are of T‐cell origin (>90%) 15 . Precursor B‐ and T‐cell malignancies are primarily seen in children and young adults, with sporadic cases at older ages 1 …”

PET/CT Evaluation of the Effect of Allogeneic Hematopoietic Stem Cell Transplantation in the Treatment of T-Cell Lymphoblastic Lymphoma

“…e probability of occurrence of T-cell lymphoblastic lymphoma disorders accounts for about 90% of all lymphoblastic lymphoma disorders and is currently the focus of clinical research [3]. At present, T-cell lymphoblastic lymphoma and T-cell acute lymphocytic leukemia (T-ALL) are defined as the same type of disease in clinical practice [4,5].…”