Cutaneous Intravascular Anaplastic Large T-Cell Lymphoma

Iacobelli, Jean; Spagnolo, Dominic V.; Tesfai, Yordanos; Giardina, Tindaro; Chan, Josephine; Joske, David; Wood, Benjamin A.

doi:10.1097/dad.0b013e31824fec43

Cited by 33 publications

(28 citation statements)

References 9 publications

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“…However, the follicular lymphoma was not identified in the initial bone marrow biopsy despite a retrospective review of the cervical LN biopsy slides obtained 3 years before and showed diagnostic features of a follicular small cleaved cell lymphoma. [41][42][43][44][45][46] The median age of the reported patients is 56 (age, 33-86) years, with a male-to-female ratio of 5:4. When she returned 3 years later, she was found to have worsening symptoms, including more prominent skin nodules with liver involvement.…”

Section: Discussionmentioning

confidence: 99%

Unusual Variants of Intravascular Malignant Hematopoietic Neoplasms

Nguyen

Yassin

Magro

2015

The American Journal of Dermatopathology

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Intravascular lymphoma (IVL) is a rare and fatal disease, typically of B-cell origin. Most of the reported cases have been for primary IVL, and only a minority of cases are of recurrent IVL. In addition, recurrent IVL occurring after treatment of anaplastic large T-cell lymphoma (ALCL) by contrast is extraordinarily rare. In this article, we present 3 cases of recurrent cutaneous IVL (2 men and 1 woman) and compare these with 1 case of primary IVL. The patients ranged in age from 56 to 73 years and were encountered in the routine dermatopathology and consultative practices of one of the authors. In 2 of the cases, the patients had intravascular cutaneous ALCL. In regard to the remaining 2 patients, 1 patient had a recurrent intravascular cutaneous follicular lymphoma in the context of a history of diffuse large B-cell lymphoma. The fourth patient had a primary intravascular ALCL because there was no antecedent history. In all cases, the skin biopsies showed large aggregates of atypical cells within the blood vessels. Phenotypic studies revealed variable staining results with CD29 and CD54 in cases of recurrent IVL compared with those of primary IVL. Recurrent cutaneous IVL represents a somewhat heterogeneous group of lymphoproliferative disorders with a distinct variant being in the context of intravascular ALCL; the mechanisms of intravascular localization in recurrent IVL are likely different from those of primary IVL.

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Section: Discussionmentioning

confidence: 99%

Unusual Variants of Intravascular Malignant Hematopoietic Neoplasms

Nguyen

Yassin

Magro

2015

The American Journal of Dermatopathology

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“…It is commonly defined as a rare subtype of extra-nodular DLBCL [11,12]; however, recent reports have demonstrated IVL with natural killer cells or T-cell lymphomas [44,45].…”

Section: Ivl Frequencymentioning

confidence: 99%

Diagnostic imaging of hepatic lymphoma

Abé

Kamimura

Kawai

et al. 2015

Clinics and Research in Hepatology and Gastroenterology

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“…A rare T-cell and NK cell variant of intravascular lymphomas has been described and is associated in some cases with EBV. 122 Iacobelli and colleagues 123 reported a case of intravascular ALCL restricted to the skin. The T-cell and NK-cell variant is not included as a distinct entity or subtype in the current WHO classification.…”

Section: Intravascular Large B-cell Lymphomamentioning

confidence: 98%

Pathologic Diagnosis of Cutaneous Lymphomas

Kempf

Mitteldorf

2015

Dermatologic Clinics

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Primary cutaneous lymphomas comprise a prognostically heterogeneous group of lymphocytic skin neoplasms, which display a broad spectrum of clinical, histologic, immunophenotypic, and genetic features. The histopathological examination plays an essential role and is often the starting point in the diagnostic workup of cutaneous lymphomas. In most cases, the histopathological and the phenotypic analysis alone are limited to provide a list of differential diagnoses. As a consequence of overlapping clinical, histologic, phenotypic, and genetic features among several entities of cutaneous lymphomas, the clinicopathological correlation is of utmost importance to achieve the final diagnosis.

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Cutaneous Intravascular Anaplastic Large T-Cell Lymphoma

Cited by 33 publications

References 9 publications

Unusual Variants of Intravascular Malignant Hematopoietic Neoplasms

Unusual Variants of Intravascular Malignant Hematopoietic Neoplasms

Diagnostic imaging of hepatic lymphoma

Pathologic Diagnosis of Cutaneous Lymphomas

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