Cutaneous immunopathology

Harrist, Terence J.; Mihm, Martín C.

doi:10.1016/s0046-8177(79)80109-4

Cited by 78 publications

(9 citation statements)

References 242 publications

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“…DIF patterns considered typical of LE, as previously described [11,18,19,20,21,22,23,24], are granular immune deposits, principally of IgG and IgM, and C3 found along the dermoepidermal junction. Deposits of fibrinogen in the same distribution are often found as well [27, 28].…”

Section: Methodsmentioning

confidence: 70%

“…In some cases, globular deposits may be present in the external root sheath of the hair follicles [20]. Additionally, a diffuse band of fibrin stains along the dermoepidermal junction and around follicles [15, 16].…”

Section: Methodsmentioning

confidence: 99%

“…In LE, DIF studies most commonly demonstrate granular deposits of immunoglobulin (fig. 2) and C3 at the dermoepidermal junction [11,18,19,20,21,22,23,24]. In PB, DIF is negative or occasionally demonstrates IgM [8, 25].…”

Section: Introductionmentioning

confidence: 99%

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Value of Direct Immunofluorescence for Differential Diagnosis of Cicatricial Alopecia

Trachsler

Trüeb²

2005

Dermatology

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Background: There are diverse causes of cicatricial alopecia characterized by lack of follicular ostia and irreversible loss of hair. While clinical differentiation between the causes may be difficult, particularly with regard to lichen planus (LP), lupus erythematosus (LE) and pseudopelade of Brocq (PB), it has been suggested that both histopathologic examination and direct immunofluorescence studies (DIF) are necessary for an accurate diagnosis. Objective: The aim of this study was to evaluate the diagnostic value of DIF studies in addition to histopathology in patients with cicatricial alopecia as a clinical feature. Methods: 136 scalp biopsy specimens received for histopathology and DIF during a 5-year period were reviewed. Results: Definitive diagnosis was achieved by careful evaluation of scalp biopsies. The most prevalent diagnoses in order of frequency were LP (26%), LE (21%) and folliculitis decalvans (20%). PB was diagnosed in 10%. In most cases, the diagnosis could be made on the basis of histopathology and independently of DIF. Characteristic DIF patterns showed high specificity, but low sensitivity for LP, and high specificity and sensitivity for LE. The DIF pattern in PB showed no difference to LP. Conclusions: Histopathology permits diagnosis in the majority of cicatricial alopecias. DIF is of value in histopathologically inconclusive cases, particularly when LE is in question.

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Section: Methodsmentioning

confidence: 70%

Section: Methodsmentioning

confidence: 99%

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Value of Direct Immunofluorescence for Differential Diagnosis of Cicatricial Alopecia

Trachsler

Trüeb²

2005

Dermatology

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“…For diagnosis of any pemphigus disease, its sensitivity has been found to range from 80–95% (53). DIF becomes positive earlier in the course of disease than IIF and is thus, considered slightly more reliable in detecting the initial presentations of PF (54).…”

Section: Diagnosismentioning

confidence: 99%

Diagnosis and Clinical Features of Pemphigus Foliaceus

James

Culton

Díaz

2011

Dermatologic Clinics

111

143

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“…Various mosaic neurocutaneous phenotypes such as midline lesions of the skin and soft tissue with neural defects [8] have so far been described. Clinical criteria distinguish the disorder of our patient from well-de®ned mosaic neurocutaneous disorders such as encephalocraniocutaneous lipomatosis, Feuerstein-Mims syndrome, CHILD syndrome or Proteus syndrome.…”

Section: Discussionmentioning

confidence: 99%